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On Saturday night, Stipe Miocic will once again enter the Octagon to defend the heavyweight championship. This time, in the main event of UFC 260, he meets the most feared striker in the sport when he faces red-hot Francis Ngannou.

Ngannou previously came up short in an attempt to win the title from Miocic, losing a decision at UFC 220. Ngannou will enter the Octagon on a four-fight winning streak, winning all four fights by knockout and with no opponent lasting more than 71 seconds.

In the co-main event, former welterweight champion Tyron Woodley will try to snap his current three-fight losing skid when he takes on the fast rising challenger in Vicente Luque. Woodley has fallen on hards times since losing the title to Kamaru Usman in 2019, with a pair of defeats to Gilbert Burns and Colby Covington in 2020 where he looks disengaged and gunshy. Now, he gets a knockout artist in Luque who has 17 stoppages in 19 career wins.

Below is all the information you need to catch UFC 260 on Saturday night, along with the complete main cards and odds provided by William Hill Sportsbook.

How to watch UFC 260 prelims

Date: March 27 | Location: UFC Apex -- Las Vegas
Time: 8 p.m. ET
Channel: ESPN | Stream: fuboTV (Try for free)

How to watch UFC 260 main card

  • Date: March 27
  • Location: UFC Apex -- Las Vegas, Nevada
  • Start time: 10 p.m. ET
  • How to watch: ESPN+ PPV (main card) | Price: $64.99

Now, here's a look at the UFC 260 main fight card and betting odds via William Hill Sportsbook.

UFC 260 main card, odds

FavoriteUnderdogWeightclass

Francis Ngannou -140

Stipe Miocic (c) +120

Heavyweight title

Vicente Luque -240

Tyron Woodley +200

Welterweight

Sean O'Malley -340

Thomas Almeida +270

Bantamweight

Miranda Maverick -165

Gillian Robertson +140

Women's flyweight

Khama Worthy -125

Jamie Mullarkey +105

Welterweight