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There's a grudge match set to go down in Las Vegas on Saturday night when Jorge Masvidal and Colby Covington battle in the main event of UFC 272. The welterweight bout headlines a card set for the T-Mobile Arena that airs live on pay-per-view after prelims on ESPN and ESPN+.

Both men lost to welterweight champion Kamaru Usman in their most recent outings, a second loss to the champ for both men. Now, these friends-turned-rivals will see their trash talk come to blows with their status in the 170-pound division -- and supremacy over their foe -- on the line.

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Plus, an interesting co-main event is on tap when former lightweight champion Rafael dos Anjos takes on Renato Moicano on short notice. Rising featherweight contender Bryce Mitchell is back when he takes on veteran Edson Barboza in an old-school clash of styles. Mitchell has risen to prominence with his wrestling base while Barboza is known for his brutal kicks. Elsewhere, Kevin Holland makes his return to the welterweight division when he takes on Alex Oliveira while former NFL star defensive end Greg Hardy looks to end a losing streak when he takes on Serghei Spivac to open the PPV festivities.

Below is all the information you need to catch UFC 272 on Saturday night. 

How to watch UFC 272 prelims

Date: March 5 | Location: T-Mobile Arena -- Las Vegas
Time: 8 p.m. ET (6 p.m. ET for early prelims)
Channel: ESPN | Stream: ESPN+

How to watch UFC 272 main card

Date: March 5 | Location: T-Mobile Arena -- Las Vegas
Time: 10 p.m. ET
Stream: ESPN+ | Price: $74.99

Now, here's a look at the UFC 272 main fight card and betting odds via Caesars Sportsbook.

UFC 272 main card, odds

FavoriteUnderdogWeightclass

Colby Covington -330

Jorge Masvidal +260

Welterweight

Rafael dos Anjos -175

Renato Moicano +150

Catchweight

Bryce Mitchell -165

Edson Barboza +140

Featherweight

Kevin Holland -360

Alex Oliveira +270

Welterweight

Serghei Spivac -195

Greg Hardy +165

Heavyweight

Who wins Masvidal vs. Covington? And which fighter is a must-back? Visit SportsLine now to get detailed top picks on UFC 272, all from the insider who's up more than $10,000 on MMA picks the past two years, and find out.