NFL Week 12 betting and fantasy live updates: Latest odds and info on line moves, injuries and more

Week 12 may not be the slate we expected (the Ravens-Steelers game has already been rescheduled twice), but it's the one we're getting, and there are certainly going to be several exciting matchups on tap. A shootout could be in store when the Chargers travel to Buffalo, we'll learn a lot about the AFC South in the Titans-Colts rematch, and we get another Tom Brady vs. Patrick Mahomes games on the late slate.

We're here to track all the betting and fantasy angles you need to know in the run up to kickoff of the Sunday slate, including line movements, injury updates, inactive lists, depth chart news, the buzz on the betting market, key information from our partners at William Hill Sportsbook and plenty more.

Here's a look at the NFL odds for each Week 12 game as of Sunday afternoon (12:40 p.m. ET):

Chargers at Bills (-4), O/U 51.5
Titans at Colts (-3), O/U 51
Dolphins (-7.5) at Jets, O/U 45
Giants (-6.5) at Bengals, O/U 45
Cardinals (-1) at Patriots, O/U 50.5
Browns (-7) at Jaguars, O/U 48
Panthers at Vikings (-3), O/U 50
Raiders (-3.5) at Falcons, O/U 53
Saints (-16.5) at Broncos, O/U 36.5
49ers at Rams (-5.5), O/U 44.5
Chiefs (-3.5) at Buccaneers, O/U 56
Bears at Packers (-8), O/U 44.5
Seahawks (-6) at Eagles, O/U 48.5

Before you get to the latest buzz, let's make sure you have all the right tools to dominate Week 12:

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Raiders more than a field goal favorite

Las Vegas is now surrendering 3.5 points to the Falcons heading into their Week 12 matchup. Atlanta will be without both Julio Jones and Todd Gurley for this matchup, which may be what has money flowing into the direction of the Raiders to drive this spread higher. Las Vegas has covered four straight games, which is tied for the longest streak in the NFL. They are 4-1 ATS on the road this season, while Atlanta is 1-4 ATS at home.

Vikings inactives: Irv Smith, Thielen down

Inactives: DE Jordan Brailford, OT Ezra Cleveland, LS Austin Cutting, CB Dylan Mabin,WR K.J. Osborn, S Curtis Riley, TE Irv Smith

The Vikings will not have tight end Irv Smith Jr. (groin) for Sunday's matchup with the Panthers. Smith did not practice on Thursday or Friday so his status is not totally surprising. That is just another hit to the Vikings passing game, however, the team will also be without star receiver Adam Thielen, who was placed on the reserve/COVID list earlier this week. 

Jaguars inactives: No Chark or Conley at WR

Inactives: WR DJ Chark, WR Chris Conley, TE Tyler Davis, S Reggie Gilbert, CB Sidney Jones, QB Gardner Minshew, RB Dare Ogunbowale

This Jaguars offense is going to look nothing like we projected it to look in Week 1. Minshew is out, the Jaguars have benched Jake Luton, and now they turn to veteran retread Mike Glennon. He won't have his projected No. 1 WR in Chark, or a fellow WR starter in Conley, but he will have impressive rookie RB James Robinson. Good luck, Mike!

November 29, 2020, 5:07 PM

Panthers inactives: McCaffrey down, Okung up 

Inactives: QB Will Grier, RB Christian McCaffrey, CB Donte Jackson, S Sam Franklin, G Dennis Daley, T Greg Little

Christian McCaffrey (shoulder) was ruled out before the Panthers traveled to Minnesota, meaning that  Mike Davis will get his ninth start in place of the star running back. On the bright side, left tackle Russell Okung will play for the first time in over a month after suffering a calf injury back on Oct. 25 in a loss vs. New Orleans. 

Giants inactives: McKinney makes his debut

Inactives: K Ryan Santoso LB TJ Brunson S Montre Hartage OL Kyle Murphy DL RJ McIntosh OLB Trent Harris

The story here is that Giants rookie second-round pick Xavier McKinney will make his NFL debut after missing time with a broken foot. McKinney projects as an excellent fit in DC Patrick Graham's system for the surprisingly strong Giants defense. 

November 29, 2020, 5:02 PM

Browns inactives: No surprises

Inactives: CB Denzel Ward, RB Dontrell Hilliard, S Sheldrick Redwine, C Nick Harris

Denzel Ward (calf) was already ruled out on Friday by the Browns. In his place, Kevin Johnson is expected to start at corner for Cleveland. Johnson has suited up in eight games for the Browns this season (two start) and has 25 tackles, a pass defended and one forced fumble. 

Titans inactives: No surprises

Inactives: WR Adam Humphries CB Adoree' Jackson LS Matt Orzech TE MyCole Pruitt DL Larrell Murchison

The Titans have been without Humphries for most of the season so that won't change much of what they do on offense and the same can be said about Jackson on defense. The Titans enter this one relatively healthy. 

November 29, 2020, 4:56 PM

Bengals inactives: Gio Bernard active 

Inactives: OT Fred Johnson, WR Mike Thomas, G B.J. Finney, G Keaton Sutherland, K Austin Seibert

Running back Gio Bernard was trending in the right direction all week as he dealt with his concussion. After not practicing on Wednesday, he was a limited participant on Thursday and practiced fully by Friday. That was a strong indication that he'd be good to go for this matchup with the Giants, despite being listed as questionable. His presence in the backfield could be crucial with both quarterback Joe Burrow and fellow running back Joe Mixon on IR. 

Bills inactives: No Kroft could make Knox a sneaky play

Inactives: QB Jake Fromm, TE Tyler Kroft, DE Trent Murphy, RB T.J. Yeldon

Some of us in the fantasy football community have been long awaiting athletic TE Dawson Knox's breakout game. Knox has flashed at times but he hasn't gotten much of an opportunity for snaps or targets while playing behind Tyler Kroft. With Kroft inactive and an excellent matchup against the Chargers leaky defense, this could be the game where Knox surprises and lands in the top-5 of TEs for fantasy this week. If you're desperate at TE, add and start Knox.

November 29, 2020, 4:52 PM

Colts inactives: Rivers, Nelson given the green light

Inactives: DE Ben Banogu, QB Jacob Eason, C Ryan Kelly, LB Bobby Okereke, WR Dezmon Patmon, CB Isaiah Rogers, TE Noah Togiai

The Colts will have two key pieces to its offense ready to roll against the Titans in a pivotal AFC South matchup. After officially being listed as questionable, quarterback Philip Rivers (toe) and star offensive lineman Quenton Nelson (back, ankle) are active for Week 12. Indy will be without star defensive lineman DeForest Buckner and running back Jonathan Taylor after the two were placed on the reserve/COVID-list prior to this matchup. 

Jets inactives: Sam Darnold back, O-line depleted

Inactives: RT George Fant, LG Alex Lewis, OL Chuma Edoga, TE Ross Travis, QB James Morgan

The New York Jets will have starting quarterback Sam Darnold back under center this week after mission the previous two games. That said, the young quarterback will be missing two starters along the offensive line. Alex Lewis was added to the injury report on Friday and was a limited participant in practice, but the team stated it was not injury-related. Darnold will have his full complement of receivers in Perriman, Crowder and Mims today too. 

Chargers inactives: Ekeler returns to action

Inactives: RB Kalen Ballage, DL Cortez Broughton, CB, Casey Hayward, OL Storm Norton, DE Uchenna Nwosu, OL Tyree St. Louis, QB Easton Stick

The big story here is the return of Austin Ekeler from IR. The top fantasy draft pick (late first, early second-round pick) has missed most of the season with a hamstring injury. However, the few snaps he did get to take with future Rookie of the Year Justin Herbert were exceptional. With Kalen Ballage out, Ekeler could see a big role right away and be a game-changer for fantasy teams down the stretch run. 

November 29, 2020, 4:45 PM

Dolphins inactives: Tua officially out

Inactives: QB Tua Tagovailoa, RB Salvon Ahmed, FB Chandler Cox, G Solomon Kindley, DT Benito Jones

The left thumb injury had the Dolphins downgrade Tagovailoa to doubtful on Saturday and now the rookie quarterback is officially sidelined for Sunday's AFC East matchup with the New York Jets. With Tagovailoa on the shelf, it'll be Ryan Fitzpatrick, who'll get the nod under center. Fitzpatrick is 3-3 as Miami's starter this season. 

Cardinals inactives: Kyler Murray is a go

Inactives: RB Eno Benjamin, QB Brett Hundley, OL Joshua Miles, OL Justin Murray, S Jalen Thompson

After being limited this week with a right shoulder injury, starting quarterback Kyler Murray is good to go for Sunday's matchup with the Patriots. While Murray may have been given the green light, he will be without one of his go-to weapons in Larry Fitzgerald, who is on the reserve/COVID list. 

Raiders inactives: No Ferrell

Inactives: DE Clelin Ferrell, RB Jalen Richard, QB Marcus Mariota, G John Simpson, DT Daniel Ross 

The Raiders will once again be without their 2019 first-round pick and edge rusher Clelin Ferrell. This is a defense that has struggled to generate pressure and that could continue against a Falcons passing attack that will be without Julio Jones. Look for a big game from Calvin Ridley. 

November 29, 2020, 4:39 PM

Patriots inactives: Sony Michel returns

Inactives: QB Brian Hoyer, RB J.J. Taylor. DE Tashawn Bower, DT Byron Cowart, WR Isaiah Ford

Sony Michel will make his return to the Patriots backfield against the Cardinals in Week 12, marking his first game action since Week 3. Michel was activated off IR last week, but didn't play in New England's loss to the Texans. Now, he'll complement Damien Harris and James White in the backfield while adopting a chunk of the snaps left by Rex Burkhead, who suffered a season-ending knee injury last week. 

Falcons inactives: No Julio Jones, Gurley

Inactives: WR Julio Jones, RB Todd Gurley, RB Qadree Ollison, CB Tyler Hall, OT John Wetzel, DT Deadrin Senat

Julio Jones re-aggravated a hamstring last week and the Falcons are putting him on the shelf for Week 12. With Jones and Todd Gurley out, Atlanta's offense will now lean on Calvin Ridley, Hayden Hurst and Brian Hill against the Raiders. 

Dolphins inch up to touchdown favorite over New York

Miami sat as a 6.5 point favorite heading into Sunday, but that has since bumped up a half-point to have them surrendering a full touchdown mark to the winless Jets. New York has covered three of their last four games, including the last two home games. The Dolphins, who'll start Ryan Fitzpatrick today, are 4-1 ATS over their last five games after falling to the Broncos in Week 11. Miami is 4-0 ATS following their last four ATS losses.

Rams spread drops below key number

After sitting at Rams -6.5 on Saturday, Los Angeles' spread over the San Francisco 49ers has dipped a point to -5.5 leading up to their Week 12 head-to-head. Now, a touchdown (minus the extra point) or two field goals, won't be enough to cover for Sean McVay's club. If history tells us anything, that shouldn't be a problem, however. San Francisco is 0-3 ATS in their last 3 games (at SEA, vs GB, at NO), losing each game by double-digits. The Niners are also not particularly strong coming out of the bye, owning a 1-7 ATS mark following their last 8 bye weeks. 

Patriots-Cardinals nearing pick'em

After sitting as a two-point road favorite, the Cardinals are nearing a pick'em for their Week 12 matchup against the Patriots in New England. The line has since dropped a full point on Sunday morning at Cardinals -1. Arizona has struggled a bit as of late going 0-3 ATS after starting the year 5-2 ATS. That said, Kyler Murray and Kliff Kingsbury are 8-3-2 ATS on the road together. As for the Patriots, they are currently a home dog for the second consecutive game this season. Under Bill Belichick, New England is 13-3 ATS as a home underdog (11-5 SU). 

This game is poised to be a high-scoring affair as the total has jumped over the 50 threshold and sits at 50.5 on Sunday morning. Arizona Unders are 4-0-1 on the road this season.

Patriots get a late push from bettors

Arizona opened the week as 2.5-point road favorites over New England, but the Bill Belichick effect likely played some kind of role in this spread moving in the other direction. After moving to 2 earlier this week, the line has dropped all the way down to Cardinals -1 on Sunday. No one likes betting against Belichick.

November 29, 2020, 3:37 PM

Saints-Broncos line explodes after QB fiasco

As expected, the line for this game has changed dramatically upon the news of every Broncos quarterback -- Drew Lock, Brett Rypien, and Blake Bortles -- being ruled ineligible to play on Sunday after being deemed close contacts to teammate Jeff Driskel, who tested positive for COVID-19 this week. Now, the team is looking to start receiver Kendall Hinton, who played quarterback at Wake Forest. With that dramatic shakeup under center, the Saints are currently looked at as a 15.5 point favorite against Denver, which increased from a six-point road favorite on Saturday before the news broke. The total also dipped to 36.  

TE injuries to know

Tyler Higbee, one of fantasy's biggest busts at the TE position, is questionable. Zach Ertz is expected to make his return for the Eagles on Monday Night Football. Hayden Hurst is questionable for the Falcons. 

November 28, 2020, 10:15 PM

WR injuries to know

John Brown is out and placed on IR so the Bills will likely move Gabriel Davis into his role. Julio Jones is officially questionable with -- you guessed it -- a hamstring injury. Broncos rookie first-rounder Jerry Jeudy is questionable with an ankle injury. Marquez Valdes-Scantling is questionable with an Achilles injury. 

November 28, 2020, 10:14 PM

RB injuries to know

The Patriots will be without Rex Burkhead so that means more touches for Damien Harris. The Panthers will once again be without Christian McCaffrey, ushering in the Mike Davis show. The Chargers have officially activated Austin Ekeler off of injured reserve and he is expected to make his return to action. Brian Hill will start in place of Todd Gurley who has been ruled out. Gio Bernard is officially questionable to play with a concussion for an already-ailing Bengals offense. Chris Carson is not listed on the injury report and expected to make his return to action.

November 28, 2020, 10:06 PM

QB injuries to know

Teddy Bridgewater (knee) is slated to make his return to the Panthers starting lineup against a suspect Vikings defense. The Jaguars are turning to their third starting QB this season -- veteran Mike Glennon will draw the start this Sunday against the Browns who will be without arguably their two best defensive players -- DE Myles Garrett and CB Denzel Ward. Ryan Fitzpatrick will most likely draw the start for the Dolphins against the Jets as Tua Tagovailoa was downgraded to doubtful on Saturday. Mitchell Trubisky has been named the starter for the Bears against the Packers with Nick Foles ruled out. 

November 28, 2020, 9:55 PM

Weather not expected to impact Week 12

Generally, right after Thanksgiving, the weather turns in several key areas of the country and becomes a major factor in deciding point totals and NFL games. That won't be the case this Sunday, however, as only Bills-Chargers (in Buffalo) and Browns-Jaguars (in Jacksonville) call for wind gusts -- and those will be just 10 mph -- and unlikely to impact either game at all.

November 28, 2020, 9:52 PM

Chargers pick up steam as road dog

Despite the fact that the Buffalo Bills will be well-rested coming off their bye week, the Los Angels Chargers, led by likely Offensive Rookie of the Year Justin Herbert, are picking up steam as a road underdog. The Bills opened the week as 5.5-point favorites and that line jumped to Bills -6 on Monday morning. However, the line has since dropped to Bills -5.5, Bills -5, and now where it stands as Bills -4.5 heading into Saturday evening.

November 28, 2020, 9:49 PM

Packers-Bears keeps moving in one direction

The Green Bay Packers opened as 8-point favorites over their bitter rival, the Chicago Bears, but that line has moved quite rapidly in one direction. The line jumped to Packers -8.5 just one day later before taking a massive jump on Friday afternoon to Packers -9.5 once Mitchell Trubisky was officially named the Bears starting QB with Nick Foles ruled out.

November 28, 2020, 9:47 PM

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