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Borussia Dortmund reeled off four wins and a draw after losing its first match in the group stage of the 2020-21 UEFA Champions League. The stretch helped secure first place in Group F for the German side, which has lost in the Round of 16 each of the last two seasons. Borussia Dortmund is looking to avoid being knocked out at this stage a third straight time, a quest it begins when it visits Sevilla on Wednesday in the first leg of the 2020-21 UEFA Champions League Round of 16. Dortmund has yet to defeat Sevilla, losing 1-0 at home in the group stage of the 2010-11 UEFA Europa League before playing to a 2-2 draw in Spain later in that competition.

Kickoff from Ramon Sanchez Pizjuan Stadium in Seville, Spain is scheduled for 3 p.m. ET. The latest Sevilla vs. Borussia Dortmund odds from William Hill Sportsbook list Sevilla at +140 and Borussia Dortmund at +200, while the over-under for total goals scored is 2.5. Before locking in any Borussia Dortmund vs. Sevilla picks, be sure to see the UEFA Champions League predictions and betting advice from SportsLine's proprietary European soccer model.

Created by two Norwegians -- professional poker player and sports bettor Jonas Gjelstad, and economics and engineering expert Marius Norheim -- the model analyzes worldwide betting data and exploits market inefficiencies, helping its followers cash in. Since coming to SportsLine in 2019, the algorithm is up more than $8,900.

The model also made some strong calls in the final group stage of the Champions League, correctly predicting RB Leipzig (+150) defeating Manchester United, Sevilla (+135) knocking off Rennes and Liverpool playing to a draw (+275) with Midtjylland.

Now, the model has set its sights on Borussia Dortmund vs. Sevilla. You can visit SportsLine now to see the picks. Here are several odds and trends for Sevilla vs. Borussia Dortmund:

  • Sevilla vs. Borussia Dortmund spread: Sevilla -0.5
  • Sevilla vs. Borussia Dortmund over-under: 2.5 goals
  • Sevilla vs. Borussia Dortmund money line: Sevilla +140, Borussia Dortmund +200
  • SEV: Sevilla has outscored its opponents 18-1 during its winning streak
  • BD: Dortmund has scored at least two goals in four of its last five matches

Top Champions League predictions for Sevilla vs. Borussia Dortmund

The model is leaning over 2.5 goals in Wednesday's matchup between Sevilla and Borussia Dortmund. Sevilla is riding a nine-game winning streak during which it has allowed just one goal. However, the Spanish team has averaged two goals during the run, and it recorded at least that many in three of its six Champions League matches. Moroccan forward Youssef En-Nesyri has produced 17 goals for Sevilla this season, posting a pair of hat tricks in La Liga action and a pair of two-goal efforts in Champions League play.

As Erling Haaland goes, so goes Borussia Dortmund's offense. The 20-year-old has produced 28 goals in 31 matches over parts of two Bundesliga seasons with the team and has recorded 23 tallies in as many overall games this campaign. Haaland has scored in each of his four outings in the UEFA Champions League, totaling six goals during that span, which is one of the reasons the model is leaning toward the over on Wednesday.

How to make Champions League picks for Sevilla vs. Borussia Dortmund

The model has also locked in a strong money-line pick for Borussia Dortmund vs. Sevilla. You can get that pick at SportsLine.

So who wins Sevilla vs. Borussia Dortmund? And where does all the betting value lie? Visit SportsLine now to find out which side of the Borussia Dortmund vs. Sevilla money line has all the value, all from the proprietary European soccer model that's up more than $8,900.