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Novak Djokovic and Carlos Alcaraz headline a jam-packed field of top-tier players at the 2023 U.S. Open. The tournament is set to begin on Monday at 11 a.m. ET and it marks the fourth and final grand slam tournament of the year. Djokovic is seeking his 24th grand slam title and enters as arguably the best hardcourt player of all-time. However, Alcaraz won the 2022 U.S. Open, defeated Djokovic for the 2023 Wimbledon title, and will enter as the No. 1 seed in the field.

Djokovic enters the men's singles tournament as a +120 betting favorite (risk $100 to win $120) from the latest 2023 U.S. Open odds. Alcaraz is next at +175, with Daniil Medvedev listed at +900. Other U.S. Open favorites include Jannik Sinner (+1100), Alexander Zverev (+2500), and Stefanos Tsitsipas (+3000). Before making any 2023 U.S. Open picks for the men's champ, you need to see who proven SportsLine tennis handicapper Jose Onorato is backing.

Onorato grew up playing competitive tennis in Caracas, Venezuela. After coming to the United States, he trained with famed coach Nick Bollettieri at IMG Academy in Florida and faced players like Robert Farah, now one of the world's top-ranked doubles players. Onorato, who holds dual degrees in finance and economics from the University of Miami, does extensive research before placing any tennis bets. He studies current form, a player's tendencies on a particular surface, weather conditions and many other relevant factors. That systematic approach helped Onorato go 96-67-7 -- up 60.42 units -- in 2022.

Now, Onorato has scrutinized the latest U.S. Open 2023 odds and released his coveted best bets to win it all. He's sharing all of his picks and analysis at SportsLine.

Top 2023 U.S. Open men's predictions

Onorato has dug deep into the field in search of value, and we can tell you that he is not finding it in Alcaraz from a pre-tournament perspective. Alcaraz is the No. 1 seed and second-favorite in the betting odds. While Onorato believes Alcaraz is fully capable of winning the tournament, this price is too aggressive in a field that features Djokovic, Medvedev and many other talented players. Alcaraz won the 2022 U.S. Open without Djokovic in the field, but Djokovic has won six of the last nine grand slams he has participated in and 23 grand slams overall. 

Djokovic also has the best hardcourt profile in the tournament, and Alcaraz must face a more difficult road to a potential final. Medvedev could be in line for a semifinal battle with Alcaraz and, before that, Alcaraz could have to deal with Sinner, who has the fourth-best odds to win the title before the tournament. No one has repeated as a men's U.S. Open champion since Roger Federer in 2007-08, and the price isn't good enough for an investment in Alcaraz. See who else to back and fade here.

How to make 2023 U.S. Open men's picks 

Onorato has a full preview with several picks you have to see, including a bet on an overlooked player who has skills that are "ideal for hard courts." You can only see his U.S. Open 2023 picks and analysis at SportsLine.

Who wins the U.S. Open 2023, and which overlooked player could take the crown? Visit SportsLine now to see Onorato's bets for U.S. Open 2023, all from the renowned tennis expert with several high-profile future wins, and find out.

2023 Men's U.S. Open odds, top contenders

See full U.S. Open 2023 men's picks, predictions, best bets here.

Novak Djokovic +120
Carlos Alcaraz +150
Daniil Medvedev +900
Jannik Sinner +1100
Alexander Zverev +2500
Stefanos Tsitsipas +3000
Holger Rune +4000
Casper Ruud +4000
Hubert Hurkacz +4500
Taylor Fritz +5000
Frances Tiafoe +5000
Andrey Rubiev +6000
Tommy Paul +6000