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Desmond Ridder and No. 5 Cincinnati (9-0) go on the road to play Timmy McClain and South Florida (2-7) on Friday night in an AAC clash that could have an impact on the next College Football Playoff ranking. The Bearcats, currently one spot out of playoff positioning, roll into this matchup with the No. 2 ranked total defense in the AAC. They allow 312.4 yards per game. USF is 4-0 against the spread in its last four games as a home underdog. 

Kickoff is set for 6 p.m. ET at Raymond James Stadium. Caesars Sportsbook lists the Bearcats at -23.5 in the latest Cincinnati vs. South Florida odds. The over-under for total points is set at 58.5, down half a point from the opening line. Before finalizing any USF vs. Cincinnati picks, make sure you check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 11 of the 2021 season on a 31-20 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Cincinnati vs. USF and just locked in its coveted college football picks and predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for USF vs. Cincinnati:

  • Cincinnati vs. South Florida spread: Cincinnati -23.5
  • Cincinnati vs. South Florida over-under: 58.5 points
  • Cincinnati vs. South Florida money line: South Florida +1100, Cincinnati -2400
  • CIN: Bearcats are 6-0 ATS in their last six Friday games
  • USF: Over is 5-0 in Bulls last five games as a home underdog 
Featured Game | South Florida Bulls vs. Cincinnati Bearcats

Why Cincinnati can cover

The Bearcats have one of the best offenses in the AAC. They are ranked fifth in total offense with 409 yards per game with 6.7 yards per play. Cincinnati is second in the conference with 38.6 points per game. This squad has scored 38-plus in five games thus far.

The Bearcats have one of the best QB-RB duos in the country in Ridder and Jerome Ford. Ridder has thrown for 2,121 yards, 20 touchdowns and just five INTs. He's also second on the team, behind Ford, in rushing with 214 yards. Ford leads the way on the ground with 888 yards and 15 touchdowns. After two of their last three games have been decided by one score, the Bearcats will be looking to put a big number on the board in this matchup to impress the CFB Playoff committee. 

Why USF can cover

The Bulls will need to get into Cincinnati's backfield on Friday night. Their attack will be led by senior linebacker Antonio Grier. He leads the team with 65 total tackles, including 32 solo. The Georgia native has a team-high 7.5 tackles for loss. Grier has recorded at least one tackle for loss in five straight games. He also leads this defensive unit with three sacks, two interceptions, and two forced fumbles. 

Senior linebacker Dwayne Boyles is second on the team and has recorded 60 total tackles, with 31 being solo. He has logged at least seven tackles in four games this year. He had a fantastic game against East Carolina, finishing with 14 total tackles and one fumble recovery. This duo at linebacker will need to make an impact for the Bulls on Friday night. 

How to make USF vs. Cincinnati picks

SportsLine's model is leaning under on the total, projecting 53 combined points. The model also says one side of the spread hits in almost 60 percent of simulations. You can only get the model's picks at SportsLine

So who wins Cincinnati vs. USF? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.