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The Duke Blue Devils and the No. 9 Clemson Tigers will play at Wallace Wade Stadium on Monday night to start their seasons. Clemson is coming off its 11th straight year with double-digit wins. The Tigers went 11-3 in 2022. On the other sideline, Duke has 19 starters, including NFL prospect Riley Leonard at quarterback, coming back from a team that went 9-4 last year. This is the first contest between these ACC foes since 2018. 

Kickoff is set for 8 p.m. ET. The Tigers are 12-point favorites in the latest Clemson vs. Duke odds via the SportsLine consensus, and the over/under for total points scored is 54.5. Before making any Duke vs. Clemson picks, you need to see the college football predictions and betting advice from SportsLine's Josh Nagel

Nagel is a Nevada-based handicapper with more than 20 years of experience in the sports wagering industry. He has a particularly keen eye for the Tigers, going 7-1 on his college football picks involving Clemson, returning $590 to $100 bettors. Anyone who has followed his advice is way up.

Now, the expert has set his sights on Duke vs. Clemson and just revealed its picks and predictions. You can visit SportsLine now to see his CFB picks. Here are several college football odds and trends for Clemson vs. Duke:

  • Duke vs. Clemson spread: Clemson -12
  • Duke vs. Clemson over/under: 54.5 points
  • Duke vs. Clemson money line: Clemson -453, Duke +344
  • DUKE: 9-4 ATS last season 
  • CLEM: 7-7 ATS last season 
  • Duke vs. Clemson picks: See picks at SportsLine

Why Clemson can cover

The Tigers owned a stout defense in 2022 and have plenty of players returning from that team. Clemson was ranked fourth in the ACC in scoring (20.9), third in rushing defense (102.9) and sixth in total defense (334.4). Junior linebacker Jeremiah Trotter Jr. is a very instinctive and fast defender for the Tigers. Trotter Jr. does a great job in pursuit and he was the leading tackler last season.

The New Jersey native was first on the team in total tackles (89) along with 6.5 sacks. He supplied at least nine total tackles in six games last year. Junior linebacker Barrett Carter gives Clemson another talented rusher off the edge. Carter has a quick get-off and has long arms that swarm opposing players. In 2022, the Georgia native had 73 total tackles, 5.5 sacks, eight pass deflections and two forced fumbles. See which team to pick here.

Why Duke cover

Duke has some strong defenders in their front seven that don't allow teams to thrive on the ground. Last year, the Blue Devils were ranked fourth in the ACC in run defense (120.9) and fifth in scoring (22.1). Junior nose tackle Brandon Johnson is exceptional at pushing the pocket and getting behind the line of scrimmage to disrupt the run. In 2022, he was tied for first on the team in sacks (5.5) with 7.5 tackles for loss and 55 total tackles.

Senior defensive tackle DeWayne Carter provides this unit with another force up the middle. Carter owns powerful hands and has great play recognition skills. The Ohio native was first on the team in 2022 in tackles for loss (11) along with 5.5 sacks and 36 total tackles. Senior linebacker Cam Dillon brings intelligence and a secure tackler onto the field. Dillon had 60 total stops and three sacks last season. See which team to pick here.

How to make Duke vs. Clemson picks

Nagel is leaning Under on the point total. He's also found a critical x-factor that has him jumping all over one side of the spread. You can see his pick at SportsLine.

Who wins Clemson vs. Duke, and what critical x-factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the spread to jump on, all from the expert who is 7-1 on his last eight Clemson picks, and find out.