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The No. 8 Clemson Tigers (10-1) and South Carolina Gamecocks (7-4) square off in the 2022 Palmetto Bowl rivalry matchup Saturday afternoon. The Tigers have been playing stellar football throughout the year and are winners of two straight as they remain in the College Football Playoff conversation. Last week, Clemson torched Miami 40-10. Meanwhile, South Carolina logged its biggest win of the year in Week 12. The Gamecocks knocked off No. 10 Tennessee 63-38. 

Kickoff from Memorial Stadium in Clemson is set for noon ET. The Tigers are 14-point favorites in the latest Clemson vs. South Carolina odds. The over/under for total points scored is set at 53. Before making any South Carolina vs. Clemson picks, be sure to check out the college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on South Carolina vs. Clemson and just revealed its picks and predictions. You can visit SportsLine now to see the model's picks. Now, here are several college football odds and trends for South Carolina vs. Clemson:

  • South Carolina vs. Clemson spread: Tigers -14
  • South Carolina vs. Clemson over/under: 53 points  
  • South Carolina vs. Clemson money line: Tigers -600, Gamecocks -430 
  • CLEM: Tigers are 4-1 ATS in their last five games in November 
  • SC: Gamecocks are 5-2-1 ATS in their last eight non-conference games 
  • South Carolina vs. Clemson picks: See picks here

Why Clemson can cover

The Tigers have been playing solid defense. They are quickly swarming the ball carrier and forcing offenses to earn every yard. Clemson ranks fourth in the ACC in points allowed (20), third in total defense (318.7) and rushing yards allowed (104.5). Sophomore linebacker Jeremiah Trotter Jr. is a big part of this unit. 

Trotter Jr. is an instinctive player and a terrific leader. He knows how to motivate his teammates while being a tackling machine in the middle of the field. The New Jersey native leads the team in total tackles (63) with four pass deflections and 1.5 sacks. Last week, he logged nine total stops, one sack and one pass breakup. 

Why South Carolina can cover

Junior linebacker Jordan Burch plays a massive role on this defense. Burch is an athletic rusher who has light feet and good movement skills. The South Carolina native has long arms which help him win at the point of attack. He's a violent tackler and runs with non-stop effort. Burch is third on the squad in total tackles (53) and second in sacks (3.5).

Freshman defensive back Nick Emmanwori is an excellent athlete and provides plenty of versatility. Emmanwori has an outstanding combination of size, length and speed. The South Carolina native can defend tight ends and running backs while also stepping into the box to help against the run. Emmanwori leads the team with 72 total stops, including six tackles in the win over No. 10 Tennessee.

How to make South Carolina vs. Clemson picks

SportsLine's model is leaning Under on the total, projecting the teams to combine for 51 points. The model also says one side of the spread has all the value. You can only get the model's pick at SportsLine

So who wins South Carolina vs. Clemson? And which side of the spread has all the value? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.