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The Arizona State Sun Devils (1-4) will try to snap their four-game losing streak under first-year head coach Kenny Dillingham when they face the Colorado Buffaloes (3-2) on Saturday night. Arizona State opened the season with a 24-21 win over Southern Utah, but it has dropped four straight games since then. Colorado won its first three games of the season before losing back-to-back games against No. 10 Oregon and No. 8 USC. The Buffaloes reached No. 19 in the AP poll under first-year coach Deion Sanders prior to their last two losses.

Kickoff is set for 6:30 p.m. ET on Saturday at Mountain America Stadium in Tempe. Colorado is favored by 3 points in the latest Arizona State vs. Colorado odds, while the over/under is set at 58.5 points, per SportsLine consensus. Before making any Colorado vs. Arizona State picks or bets, be sure to check out the college football predictions and betting advice from SportsLine football expert Jimmie Kaylor

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his Colorado picks this season, going 11-3 on his best bets in the Buffs' first five games, including a 5-1 mark in the CU vs. USC game. He's also 18-3 on all of his CFB best bets for SportsLine this season so far. Anyone who has followed his picks is way up.

Now, he has set his sights on Colorado vs. Arizona State and just locked in its picks and CFB predictions. You can head to SportsLine now to see Kaylor's picks. Here are several college football odds and betting lines for Arizona State vs. Colorado:

  • Colorado vs. Arizona State spread: Colorado -3
  • Colorado vs. Arizona State over/under: 58.5 points
  • Colorado vs. Arizona State money line: Colorado -159, ASU +134
  • CU: QB Shedeur Sanders is averaging 356.2 passing yards per game. 
  • ASU: RB Cameron Skattebo has 318 rushing yards and 4 TDs.
  • Colorado vs. Arizona State picks: See picks at SportsLine
  • Colorado vs. Arizona State live stream: fubo (try for free)

Why Colorado can cover

Both teams might be riding losing streaks right now, but Arizona State is trending in a much worse direction. The Sun Devils have failed to cover the spread in seven of their last 10 games, including five of their last six home games. They have not won a game against a Power 5 team since last October when they beat Colorado in a 42-34 final.

However, the Buffaloes have a completely different roster and outlook this year, opening the season with a three-game winning streak that included an upset win over then-No. 17 TCU. They enter this game with some momentum after scoring the final 20 points of the game in their narrow loss to USC last week, as quarterback Shedeur Sanders finished with 371 passing yards and five total touchdowns. The Sun Devils are down to their third quarterback of the season due to injuries, so they are going to have trouble keeping pace with Colorado's explosive offense on Saturday. See which team to pick at SportsLine

Why Arizona State can cover

The Tempe desert and Mountain America Stadium can be a difficult place to play for opposing teams. The Sun Devils have covered the point spread in two straight games, and should have extra motivation with Coach Prime bringing the national spotlight to their home field. ASU has dropped four straight, but has shown signs of improvement over the last two weeks. 

Junior running back Cameron Skattebo has been effective out of the backfield for Arizona State. He enters this matchup with 318 rushing yards and four touchdowns, and 14 catches for 228 yards and a TD. He will be facing a Colorado defense that gives up 184.2 rushing yards per game. See which team to back at SportsLine

How to make Arizona State vs. Colorado picks

Kaylor has analyzed this matchup from every angle and he's going Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Colorado vs. Arizona State in the first game in Tempe for coach Deion Sanders, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Colorado vs. Arizona State picks, all from the expert who has covered college football for over a decade and is 11-3 on his Colorado best bets in 2023, and find out.