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The No. 22 Colorado Buffaloes (1-0) and the Nebraska Cornhuskers (0-1) link up in a non-conference matchup on Saturday. This is the first matchup between these schools since 2019. In that game, Colorado beat Nebraska 34-31 in overtime. Coach Deion Sanders started his tenure at Colorado with a bang last week, upsetting TCU as a 21-point underdog. Nebraska, meanwhile, had some opportunities slip away late in 13-10 loss at Minnesota, though the Cornhuskers did stay within the 7.5-point spread.

Kickoff from Folsom Field in Boulder is set for noon ET The Buffaloes are 2.5-point favorites in Nebraska vs. Colorado odds via SportsLine consensus, while the over/under for total points is 58. Before making any Colorado vs. Nebraska picks, be sure to check out the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. The proprietary computer model is off to a fast 4-2 start on all-top rated college football picks this season. Since its inception, it has generated a stunning profit of more than $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Colorado vs. Nebraska and just revealed its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and trends for Nebraska vs. Colorado:

  • Colorado vs. Nebraska spread: Buffaloes -2.5
  • Colorado vs. Nebraska over/under: 58 points 
  • Colorado vs. Nebraska money line: Buffaloes -146, Cornhuskers +123
  • COLO: Won outright as a 21-point underdog in Week 1
  • NEB: 6-7 ATS since the beginning of the 2022 season 
  • Colorado vs. Nebraska picks: See picks at SportsLine

Why Colorado can cover

The Buffaloes have a bunch of difference-makers offensively. This unit can attack a defense in so many different ways and that was showcased in Week 1. Colorado racked up 565 total yards of offense. Freshman running back Dylan Edwards is a weapon coming out of the backfield. Edwards has solid short-area quickness with impressive elusiveness.

In Week 1, the Kansas native led the team in receiving yards (135) on five receptions with three touchdowns. Junior receiver Jimmy Horn Jr. has blazing speed and agility. The USF transfer has reliable hands and looks to have a good rapport with quarterback Shedeur Sanders. On Sept. 2 versus TCU, Horn Jr. had 11 receptions, 117 yards and one score. See which team to pick here.

Why Nebraska can cover

Nebraska brings a gritty defense to the table in Year 1 under head coach Matt Rhule. The Cornhuskers gave up just 251 total yards, 55 rushing yards and only 13 points in the loss to Minnesota last week. Senior safety Omar Brown is an instinctive defender who makes plays all over the field. The Minnesota native logged seven total tackles and one interception in the season opener.

The defensive front for this group has the ability to generate plenty of pressure and get into the backfield. In Week 1, they recorded five tackles for loss and three sacks. Senior linebacker Luke Reimer does a great job in pursuit and wrapping ball carriers up. Reimer can also drop back in coverage with ease. On Aug. 31, he had five total tackles and one sack. See which team to pick here.

How to make Nebraska vs. Colorado picks

SportsLine's model is leaning Under on the point total, projecting the teams to combine for 49 points. The model also says one side of the spread hits well over 50% of the time. You can only see the model's pick at SportsLine

So who wins Colorado vs. Nebraska, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of almost $2,500 on its top-rated college football spread picks, and find out.