Two of the winningest programs in college football history square off when the No. 6 Oklahoma Sooners and the Nebraska Cornhuskers collide on Saturday at Memorial Stadium in Lincoln, Neb. The Sooners (2-0) rank fourth in all-time wins among FBS programs, with 930. The Cornhuskers (1-2) rank eighth, with 909. The programs were former rivals in the Big Eight -- and later the Big 12 - and played each other for 70 straight seasons before Nebraska left for the Big Ten after the 2010 season. The Cornhuskers will be led by Mickey Joseph, who took over as interim head coach after the firing of Scott Frost on Sunday. 

Kickoff is noon ET. The Sooners are 11-point favorites in the latest Oklahoma vs. Nebraska odds from Caesars Sportsbook, while the over/under for total points scored is 65.5. Before making any Nebraska vs. Oklahoma picks, you need to see the college football predictions and betting advice from SportsLine's advanced computer simulation model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oklahoma vs. Nebraska and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Now, here are several college football odds and betting lines for Nebraska vs. Oklahoma: 

  • Oklahoma vs. Nebraska spread: Sooners -11
  • Oklahoma vs. Nebraska over/under: 65.5 points
  • Oklahoma vs. Nebraska money line: Sooners -420, Cornhuskers +320
  • OU: Marvin Mims Jr. leads the Big 12 in all-purpose yards per game (150.5).
  • NEB: Anthony Grant ranks third in the country in rushing yards per game (142.7).
  • Oklahoma vs. Nebraska picks: See picks at SportsLine
Featured Game | Nebraska Cornhuskers vs. Oklahoma Sooners

Why Oklahoma can cover

Oklahoma has done an excellent job so far this season of applying pressure on the quarterback. The Sooners lead the Big 12 and rank third in the country in sacks per game (4.5). Junior defensive end Reggie Grimes has been a regular presence in opposing backfields, leading the Big 12 in sacks per game (2.0) and tackles for loss per game (4.5).

In addition, Oklahoma has a multipurpose threat in Mims Jr. The receiving and punt-returning dynamo ranks sixth nationally in average punt return yards (19.3), ninth in receiving yards per game (122.0), 13th in yards per reception (24.4) a

Why Nebraska can cover

Grant has been red-hot to start the season. A junior college transfer from New Mexico Military Institute who started his career at Florida State, Grant ranks third in the country in rushing yards per game (142.7). He is the first Nebraska running back to top 100 yards in each of his first three games since Bobby Reynolds in 1950.

In addition, the Cornhuskers face an Oklahoma offense that isn't on the field much. The Sooners rank second-to-last in the country in time of possession (22 minutes, 34 seconds per game). That bodes well for a Nebraska team that had the time of possession edge (31:56) against Georgia Southern.

How to make Nebraska vs. Oklahoma picks

SportsLine's model is leaning Under on the total, projecting 57 combined points. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's pick at SportsLine

So who wins Oklahoma vs. Nebraska? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.