Fresh off a big upset over then-No. 2 Iowa, No. 25 Purdue (4-2) hosts Wisconsin on Saturday in a Big Ten West matchup. The Boilermakers went on the road as 11.5-point underdogs and took down the Hawkeyes. Wisconsin, meanwhile, has won two straight, but has a 3-3 overall record this season. 

Kickoff is set for 3 p.m. ET. Caesars Sportsbook list the Badgers as 3.5-point favorites in the latest Purdue vs. Wisconsin odds. The over-under for total points is set at 41. Before locking in any Wisconsin vs. Purdue picks, you'll want to see the college football predictions and betting advice from the proven simulation model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Purdue vs. Wisconsin and just released its CFB picks and predictions. You can head to SportsLine now to see its picks. Now, here are several college football odds and betting lines for Wisconsin vs. Purdue:

  • Purdue vs. Wisconsin spread: Wisconsin -3.5
  • Purdue vs. Wisconsin over-under: 41 points
Featured Game | Purdue Boilermakers vs. Wisconsin Badgers

What you need to know about Purdue

The Boilermakers had enough points to win and then some against the Iowa Hawkeyes on Saturday, taking their game 24-7. WR David Bell and QB Aidan O'Connell were among the main playmakers for Purdue as the former caught 11 passes for one touchdown and 240 yards and the latter passed for two touchdowns and 375 yards on 40 attempts in addition to punching in one rushing touchdown.

Purdue didn't just beat the No. 2 team in the country last week, it dominated them. The Boilermakers outgained the Hawkeyes 464-273 and won the turnover battle 4-1. Cam Allen had two interceptions in the win and Branson Deen had 1.5 sacks. The victory lead Purdue into the AP Top 25 for the first time this year as it enters Saturday ranked No. 25.

What you need to know about Wisconsin

Wisconsin has struggled against the spread this season with a 2-4 ATS mark. The Badgers beat Army last week, but failed to cover as 14-point favorites. They've only covered once in their last four games. 

But the Badgers still have a rugged defense that makes life tough on opponents, giving up just 19.3 points per game. Quarterback Graham Mertz has struggled with his accuracy (55.6 percent) and has thrown seven interceptions this season. Because of that, Wisconsin has leaned on the ground game, and Chez Mellusi is leading the way on the ground with a 112-543-3 rushing line.

How to make Wisconsin vs. Purdue picks

The model is leaning under on the point total and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the model's Wisconsin vs. Purdue pick at SportsLine.

So who wins Purdue vs. Wisconsin? And which side of the spread hits in well over 60 percent of simulations? Visit SportsLine now to see which side to back, all from the model that has crushed its college football picks, and find out.