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A Sun Belt matchup features the Louisiana Ragin' Cajuns (5-4) and the Southern Miss Golden Eagles (2-7) battling on Thursday night. Both of these teams love to establish the ground game on offense. Louisiana is second in the Sun Belt in rushing yards (197.3), while Southern Miss is in the sixth spot (162.6). 

Kickoff from Cajun Field in Louisiana is at 7:30 p.m. ET. The Ragin' Cajuns are 8.5-point favorites in the latest Southern Miss vs. Louisiana odds via SportsLine consensus, while the over/under for total points scored is 52.5. Before making any Louisiana vs. Southern Miss picks, be sure to see the college football predictions and betting advice from SportsLine's proven computer simulation model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Southern Miss vs. Louisana and just revealed its picks and predictions. You can visit SportsLine now to see the model's picks. Now, here are several college football odds and trends for Louisiana vs. Southern Miss:

  • Southern Miss vs. Louisiana spread: Ragin' Cajuns -8.5
  • Southern Miss vs. Louisiana over/under: 52.5 points  
  • Southern Miss vs. Louisiana money line: Ragin' Cajuns -339, Golden Eagles +266
  • USM: The Golden Eagles are 2-6 against the spread in 2023 
  • ULL: The Rajin' Cajuns are 3-5 against the spread in 2023 
  • Southern Miss vs. Louisiana picks: See picks at SportsLine 
  • Southern Miss vs. Louisiana live stream: fubo (try for free)

Why Louisiana can cover

The Ragin' Cajuns have a furious pass rush that consistently gets after the quarterback. Louisiana is currently third in the conference in team sacks (27). This defense has three players with at least 4.5 sacks on the season. Sophomore linebacker Cameron Whitfield is having a superb campaign off the edge. Whitfield wins with finesse and speed, logging a team-high seven sacks with three forced fumbles and 30 total tackles.

On Oct. 28 against South Alabama, Whitefield totaled seven total tackles and 3.5 sacks. Junior linebacker Kendre' Gant is an instinctive defender with great awareness. Gant is always around the ball and has a knack for getting into the backfield. The Florida native is third on the team in total tackles (52) with 5.5 sacks, three forced fumbles, and three fumble recoveries. He's recorded at least seven total tackles in five games thus far. See which team to pick here.

Why Southern Miss can cover

Sophomore quarterback Billy Wiles likes to take his shots downfield. Wiles owns a strong arm and has thrown for 1,746 yards and nine passing touchdowns. The Virginia native threw for 250-plus yards in three games this season. On Oct. 28 versus Appalachian State, Wiles had a season-high 287 yards and one passing score.

Senior receiver Jakarius Caston is a reliable weapon for the Golden Eagles. Caston runs solid routes and has the speed to stretch the field vertically. The Mississippi native has logged 27 receptions for 460 yards and four touchdowns. Last week, Caston reeled in three receptions for 92 yards and one touchdown. Senior receiver Latreal Jones provides the offense with another explosive pass-catcher. Jones leads the team in receptions (31) with 450 yards and three touchdowns. See which team to pick here.

How to make Southern Miss vs. Louisiana picks

SportsLine's model is leaning Under on the point total, projecting the teams to combine for 49 points. The model also says one side of the spread hits in more than 60% of simulations. You can only get the model's pick at SportsLine.

So who wins Southern Miss vs. Louisiana, and which side of the spread hits in more than 60% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that's up well over $2k all-time on its top-rated college football spread picks, and find out.