Friday's first college football matchup features UCF and Louisville. The Knights are 2-0 ahead of the weekend after following up their close matchup against Boise State with a blowout win against Bethune-Cookman. The Cardinals lost their season opener to No. 17 Ole Miss, but rebounded with a 30-3 victory against Eastern Kentucky. 

Kickoff at Cardinal Stadium is set for 7:30 p.m. ET. The Knights are seven-point favorites in the latest UCF vs. Louisville odds from Caesars Sportsbook, while the over-under for total points scored is set at 67. Before finalizing any Louisville vs. Central Florida picks, be sure to see the college football predictions and betting advice from SportsLine's proven model

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on UCF vs. Louisville and just revealed its picks and predictions. You can visit SportsLine now to see the model's picks. Here are several college football odds and betting trends for Louisville vs. UCF:

  • UCF vs. Louisville spread: UCF -7
  • UCF vs. Louisville over-under: 67 points
  • UCF vs. Louisville money line: UCF -270, Louisville +220
  • UCF: The Knights are 18-5 straight up in their last 23 games
  • LOU: The Cardinals are 4-1 straight up in their last five home games
Featured Game | Louisville Cardinals vs. UCF Knights

Why UCF can cover

UCF has been one of the FBS's strongest programs in recent years and seems poised to put together a strong season. The Knights' versatile offense will make it tough for most teams to beat them. Gabriel's arm has accounted for more than half of the 622 yards of offense UCF has produced per game. Only one team has tallied more yards per contest in 2021. Then there's running back Isaiah Bowser, who's racked up 231 yards and five scores on 45 carries.

In its season opener, Louisville gave up 43 points to No. 17 Ole Miss, and UCF has comparable firepower. The Cardinals' defense still needs to prove it can hold off top-notch competition after holding Eastern Kentucky to three points last week.

Why Louisville can cover

The Cardinals didn't start 2021 strong, but have a weapon that no team has been able to figure out yet. Dual-threat quarterback Malik Cunningham makes Louisville's offense go and has a nose for the end zone. Cunningham has thrown for two scores and rushed for four through the first two games of the season. He has 108 rushing yards to go along with his 469 passing yards.

All four of Louisville's wins last year came at home. The Cardinals were 4-2 against the spread in 2020. Those records could bode well for success against a UCF team that hasn't played on the road this season.

How to make UCF vs. Louisville picks 

SportsLine's model is leaning over on the point total, projecting teams to combine for 74 points. The model also says one side of the spread has all the value. You can only see the pick at SportsLine

So who wins Louisville vs. UCF? And which side of the spread has all the value? Visit SportsLine now to find out which side of the spread you need to jump on Friday, all from the model that has crushed its college football picks, and find out.