Kittle isn't expected to suit up for Sunday's preseason contest at the Chargers, Nick Wagoner of ESPN.com reports.
Coach Kyle Shanahan implied the starters would play at least a quarter in preseason Week 2, but Kittle won't be among the 49ers' skill-position players to take the field Sunday. Kittle will be joined by No. 1 running back Raheem Mostert, meaning the top weapons available to Jimmy Garoppolo and Trey Lance will be Deebo Samuel, Brandon Aiyuk and Mohamed Sanu.