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Mon, Dec 22
8:15 pm
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1:30Leave, Like Or Love It: 49ers To Win NFC West
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1:16Week 15 NFL Game Picks: Titans at 49ers
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1:2749ers Playoff Outlook
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1:55Is NFC West Race Most Intriguing In NFL?
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1:25San Francisco 49ers Take Another Step Towards Playoff Football
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1:59Rough Day For Shedeur Sanders and the Browns vs the 49ers
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0:17Shedeur strikes in Cleveland: Browns rookie QB Sanders throws TD pass in first home start
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1:38Shedeur Sanders Set To Make Second Career Start For Browns
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3:40Week 13 NFL Picks: 49ers at Browns
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1:21Panthers Blow Opportunity To Take 1st In NFC South
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2:4249ers Win Despite Purdy Struggles
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3:26How Would Kyle Long Handle Jennings-Moehrig Situation
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1:1749ers Sound Off After Win vs Panthers On MNF
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1:5949ers Boost Postseason Chances Following MNF Win
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2:31Week 12 Highlights: Panthers and 49ers
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1:2349ers Overcome Brock Purdy's 3 INT To Sink Panthers
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0:51Christian McCaffrey Takes Over Against The Panthers On MNF
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0:57MUST SEE: CMC Propels 49ers Over Panthers On MNF
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0:38Is Brandon Aiyuk Disinterested In Continuing To Be A 49ers
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1:29How 49ers Should Proceed With Brandon Aiyuk
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Top 49ers News
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49ers' Brandon Aiyuk: Done for 2025
The 49ers placed Aiyuk (knee) on the reserve/left squad list Saturday, Matt Barrows of The Athletic reports.
The move means Aiyuk will not return for the rest of the season and will likely not be a part of the 49ers' plans from 2026 and beyond. Aiyuk has been recovering from ACL and MCL tears in his right knee that he sustained during the 2024 campaign, and it's unclear whether the 49ers will look to trade the 2020 first-rounder during the offseason or cut him from the roster outright.
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49ers' Christian McCaffrey: Expected to play vs. Tennessee
Although he was added to the 49ers' injury report Saturday, McCaffrey (back) is expected to play against the Titans on Sunday, Adam Schefter of ESPN reports.
McCaffrey popped up on Saturday's injury report due to a back issue, but at this time, the injury isn't considered severe enough for him to miss Sunday's contest. If McCaffrey suffers a setback or operates on a snap count, then Brian Robinson, Isaac Guerendo and Jordan James would be in line for more work out of the 49ers' backfield. McCaffrey's official status may not be announced until the 49ers submit their list of inactive players approximately 90 minutes before the 4:25 p.m. ET kickoff.
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49ers' Christian McCaffrey: Now questionable for Week 15
McCaffrey has been added to the 49ers' injury report due to a back injury, and he is listed as questionable for Sunday's game against the Titans, Matt Barrows of The Athletic reports.
McCaffrey was able to shake off an illness during Week 15 prep, but the veteran running back appears to be working through a new back issue. The injury puts McCaffrey in jeopardy of missing Sunday's game, and his official status may not be known until the 49ers announce their list of inactive players approximately 90 minutes before the 4:25 p.m. ET kickoff. If McCaffrey is unable to play, then Brian Robinson would likely take over as the 49ers' lead back while Isaac Guerendo and Jordan James provide backfield depth.
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49ers' Kurtis Rourke: Won't be available Sunday
Rourke (knee) is out for Sunday's game versus the Titans, Cam Inman of The San Jose Mercury News reports.
Rourke will have to wait at least one more week to suit up for his first NFL game as he continues to recover from the torn ACL he suffered in his final year at Indiana. Mac Jones should continue to serve as San Francisco's top option at backup quarterback behind starter Brock Purdy.
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49ers' Nick Martin: Won't play vs. Titans
Martin (concussion) is out for Sunday's game versus Tennessee, Cam Inman of The San Jose Mercury News reports.
Martin sustained a concussion in Week 13 at Cleveland prior to San Francisco's Week 14 bye, and now he'll be sidelined for Week 15 as he continues to recover. His absence could mean more reps at linebacker for veteran Luke Gifford.
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49ers' Yetur Gross-Matos: Won't suit up vs. Titans
Gross-Matos (hamstring) is out for Sunday's game versus Tennessee, Cam Inman of The San Jose Mercury News reports.
Gross-Matos was just designated for return to practice from San Francisco's injured reserve list Thursday, but he'll have to spend at least one more game on the sideline as he nurses his hamstring injury. With Sam Okuayinonu (ankle) also out, Bryce Huff and 2023 second-rounder Keion White project as the 49ers' starters on the edge in Week 15.
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49ers' Tatum Bethune: Missing another game
Bethune (ankle) has been ruled out for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports.
Bethune will miss a third consecutive game due to an ankle injury that he suffered in Week 11 against the Cardinals. Curtis Robinson will continue to start at middle linebacker due to the absences of Bethune and Fred Warner (ankle - IR). Bethune's next opportunity to play is Week 16 against the Colts on Monday, Dec. 22.
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49ers' Sam Okuayinonu: Won't play Week 15
Okuayinonu (ankle) has been ruled out for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports.
Okuayinonu will miss a second consecutive game due to an ankle injury despite having additional time to recover due to the 49ers' Week 14 bye. It's an injury that he has worked through since late October, and he'll look to progress enough in his recovery to return for San Francisco's Week 16 clash against Indianapolis on Monday, Dec. 22. Keion White, Clelin Ferrell and Robert Beal will continue to see more snaps at defensive end opposite Bryce Huff for as long as Okuayinonu is sidelined.
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49ers' Kyle Juszczyk: Cleared to play Week 15
Juszczyk (ribs) does not have an injury designation for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports.
Juszczyk fractured his rib during the 49ers' Week 13 win over the Browns. The veteran fullback had extra time to recovery courtesy of the 49ers' Week 14 bye, and he's been given the green light to play in Sunday's home game. Juszczyk has mostly operated as a backfield blocker on run plays but has also been effective in the passing attack, having hauled in 20 passes (on 23 targets) for 187 yards and a touchdown through 13 regular-season games.
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49ers' Christian McCaffrey: Cleared after full practice
McCaffrey (illness) doesn't have an injury designation for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports.
The 49ers added him to the injury report mid-week due to an illness, but McCaffrey still managed a limited practice Thursday and full session Friday. He should be fine for his usual role this Sunday against the Titans, albeit with higher-than-usual risk of being pulled early from a blowout. Of course, that might be the same scenario in which McCaffrey puts up a ton of points early in the game.
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49ers' Christian McCaffrey: Practicing Friday
McCaffrey (illness) is practicing Friday, Noah Furtado of the San Francisco Chronicle reports.
The illness apparently isn't serious, considering McCaffrey was a limited practice participant Thursday and is now practicing again Friday. He's on track to play Sunday against the Titans.
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49ers' Tatum Bethune: Remains unable to practice
Bethune (ankle) did not practice Thursday.
With consecutive DNPs to begin Week 15 prep, Bethune appears to be in real danger of missing his third straight game Sunday against the Titans. Should that be the case, Curtis Robinson would likely log another start at linebacker.
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49ers' Kyle Juszczyk: Remains limited Thursday
Juszczyk (ribs) logged a limited practice Thursday.
Juszczyk has begun Week 15 prep with consecutive limited practice sessions due to a fractured rib. The fact the veteran fullback has been able to participate in some capacity both Wednesday and Thursday suggests he has a chance of suiting up Sunday against Tennessee, though he may get an injury designation for the contest if he's not able to practice in full Friday. Should Juszczyk have to miss Sunday's game, it would mark his first absence from a regular-season contest since 2022.
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Team Statistical Rankings
| Rushing | Passing | Overall | |
|---|---|---|---|
| Off. |
98.5 (25th) |
253.7 (7th) |
341.2 (11th) |
| Def. |
103.8 (12th) |
241.2 (23rd) |
335.8 (20th) |
Injuries
| Player | Injury |
|---|---|
| C. McCaffrey RB Christian McCaffrey RB | Back |
| B. Aiyuk WR Brandon Aiyuk WR | Knee - ACL + MCL |
| F. Warner MLB Fred Warner MLB | Ankle |
| N. Bosa DE Nick Bosa DE | Knee - ACL |
| T. Bethune LB Tatum Bethune LB | Ankle |
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