Player Bio
| HT/WT: 6-0, 221 lbs |
| Birthplace: Clayton, IN |
| Age: 26 |
| School: Louisville |
| Experience: 3 |
Next Game
Now Playing
Share Video
Link copied!
-
1:23Brock Purdy, 49ers Stay Undefeated Despite Injuries
-
1:56Why the 4-0 49ers Don't Need to Lean on McCaffrey
-
1:19
NFL Week 4 Highlights: Broncos at 49ers
-
1:4449ers Pull Away from Broncos in 2nd Half to Improve to 4-0
-
5:58REACTION: 49ers Outlast Broncos, Improve to 4-0 | HQ NFL
-
1:5449ers' Balanced, Disciplined Offensive Execution
-
0:38George Kittle Takes Screen Pass for 49ers Touchdown
-
0:26Brock Purdy Finds Deebo Samuel for a 49ers Touchdown
-
0:16Broncos Block 49ers' Field Goal Attempt
-
0:32Bo Nix Escapes Pressure to Find Tyler Badie vs. 49ers
-
1:40Officially Delicious NFL Week 4 Best Bets
-
1:31Carhartt Skilled Trades: Tyler Shough or Brock Purdy?
-
0:56Broncos Inconsistencies to Be Tested vs. 49ers
-
1:17Why the Dolphins Have the NFL's Toughest Schedule
-
2:53Is Brock Purdy an MVP Candidate?
-
1:12Top 5 Landing Spots for Brian Thomas Jr. & Marvin Harrison
-
0:56Is Brock Purdy an Actual NFL MVP Candidate?
-
0:52
Player Select: Is Brock Purdy an NFL MVP Candidate?
-
1:19Six NFL Teams Remain Undefeated After Week 3
-
5:58REACTION: 49ers Improve To 3-0 With Impressive Victory Over Cardinals| HQ NFL
This page may contain affiliate links. If you click a link and sign up, make a deposit, place a wager, or make a trade, we may earn a commission at no additional cost to you.
Top Isaac Guerendo News
-
-
49ers' Isaac Guerendo: Lands on reserve/PUP list
Guerendo (pectoral) was placed on the reserve/PUP list Sunday, Jeremy Fowler of ESPN reports.
Guerendo spent all of training camp on the active/PUP list and is seemingly not ready to take the field, so he will remain on PUP and will miss at least the first four weeks of the season. As such, Kaelon Black and Jordan James will open as the top two options behind starter Christian McCaffrey (undisclosed).
... See More ... See Less -
-
49ers' Isaac Guerendo: Placed on PUP list
The 49ers placed Guerendo (pectoral) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports.
Guerendo is still recovering from a torn pectoral he suffered while lifting earlier in the offseason. While the 26-year-old will be unable to practice for now, he is expected to return at some point before the end of training camp.
... See More ... See Less -
49ers' Isaac Guerendo: Dealing with torn pectoral
Guerendo is not participating in OTAs due to a torn pectoral, Cam Inman of The San Jose Mercury News reports.
The running back suffered the injury while lifting "about a month ago," per David Lombardi of SFStandard.com. Guerendo is expected back near the end of training camp, though he did already undergo surgery, per Jeremy Fowler of ESPN.com. The 2024 fourth-round pick did not receive a single carry in 2025 despite appearing in 14 regular-season games.
... See More ... See Less -
-
-
-
-
-
-
49ers' Isaac Guerendo: Falls out of favor in 2025
Guerendo was only utilized on special teams this season, finishing with 100 kick return yards across 14 active games.
Guerendo entered his sophomore campaign with an opportunity to serve as Christian McCaffrey's primary backup, but he failed to seize the role in training camp and the team opted to trade for veteran RB Brian Robinson (92-400-2) to fill that role instead. The 25-year-old Guerendo averaged 5.0 yards per carry in his rookie season, so it was a bit surprising to see San Francisco's coaching staff give him zero carries in 2025. The Louisville product was healthy for the majority of the schedule and appeared in 14 games as a member of the special teams unit. Guerendo still has two years left on his rookie contract, but it doesn't appear that the 49ers view the running back as part of the team's long-term vision on offense.
... See More ... See Less -
-
49ers' Isaac Guerendo: Healthy scratch again in Week 17
Guerendo (coach's decision) is inactive for Sunday night's contest against Chicago.
Guerendo will be a healthy scratch for the second straight week after having played in the team's previous 14 contests. Jordan James will get another nod as the 49ers' No. 3 running back behind Christian McCaffrey and Brian Robinson in Week 17.
... See More ... See Less -
-
49ers' Isaac Guerendo: Inactive for MNF
Guerendo (coach's decision) is inactive for Monday night's game against the Colts.
Guerendo has appeared in all 14 games this season leading up to Monday night, but rookie Jordan James is getting the nod over him against the Colts as the Niners' RB3 behind Christian McCaffrey and Brian Robinson. All of Guerendo's 173 snaps this season have come on special teams.
... See More ... See Less -
-
49ers' Isaac Guerendo: Role remains marginalized
Guerendo logged three snaps on special teams in Sunday's 37-24 win over the Titans.
Guerendo remained a non-factor on offense behind Christian McCaffrey and Brian Robinson on San Francisco's running back depth chart. The 25-year-old Guerendo once returned kickoffs for the 49ers, but the team has removed him from that role completely since Week 5. Barring a string of catastrophic injuries in the backfield, Guerendo can safely be ignored during the fantasy playoffs.
... See More ... See Less -
-
