Guerendo rushed five times for 22 yards and was not targeted in Sunday's 24-23 loss to Arizona.
Guerendo backed up Jordan Mason (14-89-0) as the rookie had been through the previous four games this season. The 24-year-old Guerendo produced his highest rushing total of his young career while returning a kick for 32 yards in the upset loss. There isn't enough volume currently for the Louisville product to warrant fantasy consideration against the Seahawks on Thursday.
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49ers' Isaac Guerendo: Fumbles lone touch on offense
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Guerendo lost a fumble on his lone carry Sunday, failing to gain any yards while earning zero targets in a blowout win over the Patriots.
Guerendo had a nightmarish game that resulted in a negative fantasy score for anyone bold enough to play the sparsely-used backup against New England. In an effort to not be too harsh on the rookie, it should be noted that he gained 23 yards on San Francisco's only kickoff return Sunday. While Christian McCaffrey (calf/Achilles) mends on IR, it would take another injury to current starter Jordan Mason to give Guerendo fantasy value in most leagues heading into a Week 5 tilt against Arizona next Sunday.
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49ers' Isaac Guerendo: Week 4 Waiver Priority List
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Christian McCaffrey (calf) is seeing a specialist in Germany for his injury, so it doesn't sound like he's returning to action any time soon. That puts Guerendo in position to be Jordan Mason's backup for the 49ers, and Guerendo has lottery-ticket upside in that role. He's worth stashing in all leagues for at least 5 percent of your remaining FAB.
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49ers' Isaac Guerendo: Earns five carries Sunday
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Guerendo rushed five times for 19 yards in Sunday's 27-24 loss to the Rams.
The five carries marked a new high-water mark for the rookie after receiving just one carry for no gain in his first two appearances with San Francisco. Guerendo was spelling fill-in starter Jordan Mason (19-77-0) on Sunday, a situation that could repeat itself against the Patriots on Sunday. The 2024 fourth-round pick only warrants fantasy consideration in the event that Mason is unable to suit up in the coming weeks.
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49ers' Isaac Guerendo: Week 3 Waiver Priority List
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With Christian McCaffrey (calf) on injured reserve, Guerendo moves into the No. 2 role for the 49ers behind Jordan Mason, and Guerendo is worth stashing in deeper leagues. He only had one carry for no yards in Week 2 at Minnesota, but Guerendo could be a borderline starter in all leagues if Mason were to get hurt while McCaffrey is out. Guerendo is worth adding for up to 5 percent of your remaining FAB.
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49ers' Isaac Guerendo: No touches on 13 snaps
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Guerendo (groin) suited up for Monday's season opener against the Jets but did not record a touch in a 32-19 win.
Guerendo made the 49ers' 53-man roster but was battling a groin injury heading into Week 1. The fourth-round pick out of Louisville got the green light and wound up logging 10 snaps on special teams and three on offense. Starter Christian McCaffrey (calf/Achilles) did not suit up for this contest, allowing Jordan Mason (28-147-1) to go off against the Jets. Guerendo appears to be next in line should San Francisco need a runner behind CMC or Mason this season.
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49ers' Isaac Guerendo: Set to suit up in season opener
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Guerendo (groin) practiced in full Saturday and doesn't have an injury designation for Monday's Week 1 contest against the Jets.
Guerendo was a limited participant in each of San Francisco's first two practices of the week after missing all of last week due to a groin injury. He is in line to make his NFL debut Monday, though, after returning to a full practice session Saturday. Christian McCaffrey (calf/Achilles) is listed as questionable for the opener against the Jets but has stated that he's definitely suiting up, so Guerendo will likely see limited work in the running game behind the star tailback and backup Jordan Mason.
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49ers' Isaac Guerendo: Remains limited
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Guerendo (groin) remained limited in practice Friday, Nick Wagoner of ESPN.com reports.
The rookie missed most of training camp with a hamstring injury and then hurt his groin in late August a week after returning to practice. With Christian McCaffrey (calf) on track to play and Guerendo having taken very few practice reps this summer, there's not much chance of Guerendo having a significant role Week 1 even if he ends up being healthy enough to play.
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49ers' Isaac Guerendo: Opens week as limited participant
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Guerendo (groin) is practicing on a limited basis Thursday, Cam Inman of The San Jose Mercury News reports.
Guerendo spent the early portion of training camp sidelined due to a hamstring injury, and he then tweaked his groin after returning for San Francisco's preseason finale. The rookie fourth-round pick will have two more chances to upgrade to full participation in practice ahead of Monday's regular-season opener against the Jets. Meanwhile, top running back Christian McCaffrey (calf/Achilles) will also be limited Thursday, though he's expected to be available Week 1.
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49ers' Isaac Guerendo: Tweaks groin in practice
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Guerendo tweaked his groin Monday and won't practice this week, Cam Inman of The San Jose Mercury News reports.
After missing training camp and most of the preseason with a hamstring injury, Guerendo returned for San Francisco's final exhibition and took 13 touches for 35 yards in a 24-24 tie with the Raiders. His depth chart standing seemingly improved despite all the missed time this summer, as longtime No. 2 running back Elijah Mitchell was placed on season-ending injured reserve due to a hamstring injury that will require surgery. Jordan Mason is now expected to enter Week 1 as the No. 2 back behind Christian McCaffrey, leaving Guerendo to focus on kickoff returns for the time being. Shanahan said Guerendo could be back at practice as soon as next week, meaning the rookie isn't ruled out for a Week 1 matchup with the Jets on Sept. 9.
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49ers' Isaac Guerendo: Healthy amount of action
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Guerendo (hamstring) rushed 11 times for 32 yards and caught both of his targets for three yards in Friday's preseason tilt against Las Vegas.
Guerendo returned from a hamstring injury that cost the fourth-round pick two games of action this exhibition season. The Louisville product didn't post gaudy rushing numbers in his 49ers debut, but he had an electric kickoff return of 93 yards that fell just short of paydirt. Guerendo currently sits behind veteran backups Elijah Mitchell and Jordan Mason on the depth chart, but the 6-foot, 221-pound rookie has the physical tools to profile as a fantasy prospect should he survive the impending roster cuts ahead the Sept. 27 deadline.
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49ers' Isaac Guerendo: Could practice this week
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Coach Kyle Shanahan said Sunday he's "hopeful" Guerendo (hamstring) will be able to resume practicing this week and potentially play in Friday's preseason finale against the Raiders, Matt Barrows of The Athletic reports.
Guerendo has missed more than three weeks of training camp, including San Francisco's first two preseason games, due to a hamstring injury sustained July 24. The rookie fourth-rounder will be in a position to receive valuable reps if he's indeed able to return this week, with all of Christian McCaffrey (calf), Elijah Mitchell (hamstring) and Jordan Mason (hip) nursing injuries of their own. Friday's exhibition matchup against the Raiders represents Guerendo's last chance to log game reps before the 49ers take on the Jets in Week 1 on Monday, Sept. 9.
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49ers' Isaac Guerendo: Injures hamstring Wednesday
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Guerendo departed Wednesday's training camp practice early due to a hamstring injury, Jennifer Lee Chan of NBC Sports Bay Area reports.
The severity of Guerendo's injury isn't known, with head coach Kyle Shanahan saying that the running back will need to be evaluated further, according to Lindsey Pallares of the 49ers' official site. It's a tough start for the rookie speedster, who is working to carve out a role behind Christian McCaffrey and Elijah Mitchell. Guerendo dealt with recurring soft-tissue injuries in college, so his status will warrant close monitoring.
