Offense
| NO | Player | POS | HT | WT | DOB (AGE) | EXP | College |
|---|---|---|---|---|---|---|---|
| 3 | C. Beathard C.J. Beathard | QB | 6-2 | 215 | 11/16/1993 (25) | 3 | Iowa |
| 10 | J. Garoppolo Jimmy Garoppolo | QB | 6-2 | 225 | 11/2/1991 (27) | 6 | Eastern Illinois |
| 4 | N. Mullens Nick Mullens | QB | 6-1 | 210 | 3/21/1995 (24) | 2 | Southern Miss |
| — | W. Speight Wilton Speight | QB | 6-6 | 232 | 12/6/1994 (24) | R | UCLA |
| 22 | M. Breida Matt Breida | RB | 5-11 | 190 | 2/28/1995 (24) | 3 | Georgia Southern |
| 26 | T. Coleman Tevin Coleman | RB | 6-1 | 210 | 4/16/1993 (26) | 5 | Indiana |
| 28 | J. McKinnon Jerick McKinnon | RB | 5-9 | 205 | 5/3/1992 (27) | 6 | Georgia Southern |
| 31 | R. Mostert Raheem Mostert | RB | 5-10 | 197 | 4/9/1992 (27) | 5 | Purdue |
| — | A. Walter Austin Walter | RB | 5-8 | 202 | 11/30/0002 (2016) | 0 | Rice |
| 41 | J. Wilson Jeff Wilson | RB | 6-0 | 194 | 11/16/1995 (23) | 2 | North Texas |
| 44 | K. Juszczyk Kyle Juszczyk | FB | 6-1 | 240 | 4/23/1991 (28) | 7 | Harvard |
| 84 | K. Bourne Kendrick Bourne | WR | 6-1 | 203 | 8/4/1995 (23) | 3 | Eastern Washington |
| 11 | M. Goodwin Marquise Goodwin | WR | 5-9 | 180 | 11/19/1990 (28) | 7 | Texas |
| — | M. Henry Malik Henry | WR | 6-0 | 175 | — | R | West Georgia |
| — | J. Hurd Jalen Hurd | WR | 6-4 | 228 | 1/23/1996 (23) | R | Baylor |
| 13 | R. James Richie James | WR | 5-9 | 185 | 9/5/1995 (23) | 2 | Middle Tenn. |
| 80 | J. Matthews Jordan Matthews | WR | 6-3 | 215 | 7/16/1992 (26) | 6 | Vanderbilt |
| 1 | M. McCaffrey Max McCaffrey | WR | 6-2 | 200 | 5/17/1994 (25) | 2 | Duke |
| 18 | D. Pettis Dante Pettis | WR | 6-1 | 195 | 10/23/1995 (23) | 2 | Washington |
| — | S. Poindexter Shawn Poindexter | WR | 6-5 | 218 | — | 0 | Arizona |
| 81 | T. Taylor Trent Taylor | WR | 5-8 | 180 | 4/30/1994 (25) | 3 | Louisiana Tech |
| 88 | G. Celek Garrett Celek | TE | 6-5 | 252 | 5/29/1988 (30) | 8 | Michigan State |
| 82 | R. Dwelley Ross Dwelley | TE | 6-5 | 240 | 1/26/1995 (24) | 2 | San Diego |
| 85 | G. Kittle George Kittle | TE | 6-4 | 250 | 10/9/1993 (25) | 3 | Iowa |
| — | T. Mayfield Tyree Mayfield | TE | 6-3 | 241 | — | 0 | Wyoming |
| — | K. Smith Kaden Smith | TE | 6-5 | 253 | 4/24/1997 (22) | R | Stanford |
| 87 | L. Toilolo Levine Toilolo | TE | 6-8 | 268 | 7/30/1991 (27) | 7 | Stanford |
| 73 | W. Johnson Wesley Johnson | C | 6-5 | 309 | 1/9/1991 (28) | 6 | Vanderbilt |
| 62 | E. Magnuson Erik Magnuson | C | 6-6 | 305 | 1/5/1994 (25) | 3 | Michigan |
| 58 | W. Richburg Weston Richburg | C | 6-4 | 290 | 7/9/1991 (27) | 6 | Colorado State |
| 66 | W. Beavers Willie Beavers | G | 6-5 | 324 | 10/2/1993 (25) | 2 | Western Michigan |
| 63 | B. Garland Ben Garland | G | 6-5 | 308 | 4/6/1988 (31) | 6 | Air Force |
| 65 | J. Garnett Joshua Garnett | G | 6-5 | 305 | 2/21/1994 (25) | 4 | Stanford |
| 68 | M. Person Mike Person | G | 6-4 | 300 | 6/17/1988 (30) | 9 | Montana State |
| — | R. Reynolds Ross Reynolds | G | 6-3 | 304 | 9/14/1995 (23) | R | Iowa |
| 75 | L. Tomlinson Laken Tomlinson | G | 6-3 | 312 | 2/9/1992 (27) | 5 | Duke |
| 66 | N. Toran Najee Toran | G | 6-2 | 305 | 11/15/1995 (23) | 1 | UCLA |
| 78 | S. Coleman Shon Coleman | T | 6-5 | 310 | 11/25/1991 (27) | 4 | Auburn |
| 61 | C. DiLauro Christian DiLauro | T | 6-6 | 300 | 11/11/1994 (24) | 1 | Illinois |
| 69 | M. McGlinchey Mike McGlinchey | T | 6-8 | 315 | 1/12/1995 (24) | 2 | Notre Dame |
| — | J. Skule Justin Skule | T | 6-7 | 317 | 11/23/1996 (22) | R | Vanderbilt |
| 74 | J. Staley Joe Staley | T | 6-5 | 295 | 8/30/1984 (34) | 13 | Central Michigan |
Defense
| NO | Player | POS | HT | WT | DOB (AGE) | EXP | College |
|---|---|---|---|---|---|---|---|
| 91 | A. Armstead Arik Armstead | DE | 6-7 | 292 | 11/15/1993 (25) | 5 | Oregon |
| 98 | R. Blair Ronald Blair | DE | 6-4 | 270 | 1/21/1993 (26) | 4 | Appalachian State |
| — | J. Garcia-Williams Jamell Garcia-Williams | DE | 6-8 | 255 | — | R | UAB |
| 67 | K. Lewis-Moore Kapron Lewis-Moore | DE | 6-4 | 315 | 1/24/1990 (29) | 4 | Notre Dame |
| 95 | K. Street Kentavius Street | DE | 6-2 | 287 | 5/8/1996 (23) | 1 | NC State |
| 55 | P. Taumoepenu Pita Taumoepenu | DE | 6-1 | 245 | 3/9/1994 (25) | 2 | Utah |
| 94 | S. Thomas Solomon Thomas | DE | 6-3 | 280 | 8/26/1995 (23) | 3 | Stanford |
| 99 | D. Buckner DeForest Buckner | DT | 6-7 | 300 | 3/17/1994 (25) | 4 | Oregon |
| 96 | S. Day Sheldon Day | DT | 6-1 | 294 | 7/1/1994 (24) | 4 | Notre Dame |
| — | K. Givens Kevin Givens | DT | 6-1 | 285 | 3/1/1997 (22) | 0 | Penn State |
| 93 | D. Jones D.J. Jones | DT | 6-0 | 321 | 1/19/1995 (24) | 3 | Ole Miss |
| 63 | C. Thornton Cedric Thornton | DT | 6-4 | 290 | 6/21/1988 (30) | 7 | Southern Arkansas |
| 55 | D. Ford Dee Ford | OLB | 6-2 | 252 | 3/19/1991 (28) | 6 | Auburn |
| 47 | E. Lee Elijah Lee | OLB | 6-2 | 229 | 2/8/1996 (23) | 3 | Kansas State |
| 55 | D. Mayo David Mayo | OLB | 6-2 | 245 | 8/8/1993 (25) | 5 | Texas State |
| 53 | M. Nzeocha Mark Nzeocha | OLB | 6-3 | 240 | 1/19/1990 (29) | 5 | Wyoming |
| 51 | M. Smith Malcolm Smith | OLB | 6-0 | 225 | 7/5/1989 (29) | 9 | USC |
| 58 | K. Alexander Kwon Alexander | MLB | 6-1 | 227 | 8/3/1994 (24) | 5 | LSU |
| 48 | F. Warner Fred Warner | MLB | 6-3 | 226 | 11/19/1996 (22) | 2 | BYU |
| — | A. Al-Shaair Azeez Al-Shaair | LB | 6-2 | 231 | 8/4/1997 (21) | R | Florida Atlantic |
| — | D. Greenlaw Dre Greenlaw | LB | 6-0 | 221 | 5/25/1997 (21) | R | Arkansas |
| 50 | L. Reynolds LaRoy Reynolds | LB | 6-1 | 240 | 11/3/1990 (28) | 7 | Virginia |
| — | A. Brown Alex Brown | CB | 5-9 | 183 | — | R | South Carolina State |
| — | T. Harris Tim Harris | CB | 6-2 | 197 | — | R | Virginia |
| 26 | G. Mabin Greg Mabin | CB | 6-1 | 200 | 6/25/1994 (24) | 3 | Iowa |
| 25 | R. Sherman Richard Sherman | CB | 6-3 | 195 | 3/30/1988 (31) | 9 | Stanford |
| 20 | J. Ward Jimmie Ward | CB | 5-11 | 193 | 7/18/1991 (27) | 6 | Northern Illinois |
| 23 | A. Witherspoon Ahkello Witherspoon | CB | 6-3 | 195 | 3/21/1995 (24) | 3 | Colorado |
| — | D. Flannigan-Fowles Demetrius Flannigan-Fowles | DB | 6-2 | 209 | — | 0 | Arizona |
| 36 | M. Harris Marcell Harris | DB | 6-0 | 208 | 6/9/1994 (24) | 2 | Florida |
| 33 | T. Moore Tarvarius Moore | DB | 6-2 | 200 | 8/16/1996 (22) | 2 | Southern Miss |
| 41 | E. Moseley Emmanuel Moseley | DB | 5-11 | 184 | 3/25/1996 (23) | 2 | Tennessee |
| 49 | T. Robinson Tyree Robinson | DB | 6-2 | 215 | 4/14/1994 (25) | 1 | Oregon |
| 22 | J. Verrett Jason Verrett | DB | 5-10 | 188 | 6/18/1991 (27) | 6 | TCU |
| 24 | K. Williams K'Waun Williams | DB | 5-9 | 185 | 7/12/1991 (27) | 5 | Pittsburgh |
Special Teams
| NO | Player | POS | HT | WT | DOB (AGE) | EXP | College |
|---|---|---|---|---|---|---|---|
| 3 | J. Brown Jon Brown | K | 5-10 | 194 | 12/7/1992 (26) | 1 | Louisville |
| 9 | R. Gould Robbie Gould | K | 6-0 | 190 | 12/6/1982 (36) | 15 | Penn State |
| — | M. Wishnowsky Mitch Wishnowsky | P | 6-2 | 221 | 3/2/1992 (27) | R | Utah |
| 40 | C. Holba Colin Holba | LS | 6-4 | 248 | 7/8/1994 (24) | 2 | Louisville |
| 86 | K. Nelson Kyle Nelson | LS | 6-2 | 240 | 10/3/1986 (32) | 8 | New Mexico State |