Offense
| NO | Player | POS | HT | WT | DOB (AGE) | EXP | College |
|---|---|---|---|---|---|---|---|
| 3 | C. Beathard C.J. Beathard | QB | 6-2 | 215 | 11/16/1993 (27) | 4 | Iowa |
| 26 | T. Coleman Tevin Coleman | RB | 6-1 | 210 | 4/16/1993 (27) | 6 | Indiana |
| 28 | J. McKinnon Jerick McKinnon | RB | 5-9 | 205 | 5/3/1992 (28) | 7 | Georgia Southern |
| 48 | A. Walter Austin Walter | RB | 5-8 | 202 | 8/17/1996 (24) | 1 | Rice |
| 30 | J. Wilson Jeff Wilson | RB | 6-0 | 213 | 11/16/1995 (25) | 3 | North Texas |
| 44 | K. Juszczyk Kyle Juszczyk | FB | 6-1 | 235 | 4/23/1991 (29) | 8 | Harvard |
| 11 | B. Aiyuk Brandon Aiyuk | WR | 6-0 | 200 | 3/17/1998 (22) | R | Arizona State |
| 84 | K. Bourne Kendrick Bourne | WR | 6-1 | 190 | 8/4/1995 (25) | 4 | Eastern Washington |
| 86 | R. Cracraft River Cracraft | WR | 6-0 | 198 | 11/1/1994 (26) | 2 | Washington State |
| 13 | R. James Richie James | WR | 5-9 | 185 | 9/5/1995 (25) | 3 | Middle Tenn. |
| 19 | D. Samuel Deebo Samuel | WR | 6-0 | 215 | 1/15/1996 (25) | 2 | South Carolina |
| 82 | R. Dwelley Ross Dwelley | TE | 6-5 | 235 | 1/26/1995 (25) | 3 | San Diego |
| 85 | G. Kittle George Kittle | TE | 6-4 | 250 | 10/9/1993 (27) | 4 | Iowa |
| 81 | J. Reed Jordan Reed | TE | 6-2 | 242 | 7/3/1990 (30) | 8 | Florida |
| 89 | C. Woerner Charlie Woerner | TE | 6-5 | 241 | 10/16/1997 (23) | R | Georgia |
| 60 | D. Brunskill Daniel Brunskill | C | 6-5 | 300 | 1/27/1994 (26) | 2 | San Diego State |
Defense
| NO | Player | POS | HT | WT | DOB (AGE) | EXP | College |
|---|---|---|---|---|---|---|---|
| 91 | A. Armstead Arik Armstead | DE | 6-7 | 290 | 11/15/1993 (27) | 6 | Oregon |
| 64 | A. Barrett Alex Barrett | DE | 6-2 | 250 | 3/6/1994 (26) | 1 | San Diego State |
| 92 | K. Hyder Kerry Hyder | DE | 6-2 | 275 | 5/2/1991 (29) | 5 | Texas Tech |
| 96 | D. Jordan Dion Jordan | DE | 6-6 | 284 | 3/5/1990 (30) | 6 | Oregon |
| 95 | K. Street Kentavius Street | DE | 6-2 | 287 | 5/8/1996 (24) | 2 | NC State |
| 65 | D. Daniels Darrion Daniels | DT | 6-3 | 311 | 12/4/1997 (23) | R | Nebraska |
| 90 | K. Givens Kevin Givens | DT | 6-1 | 285 | 3/1/1997 (23) | 1 | Penn State |
| 93 | D. Jones D.J. Jones | DT | 6-0 | 305 | 1/19/1995 (26) | 4 | Ole Miss |
| 99 | J. Kinlaw Javon Kinlaw | DT | 6-5 | 319 | 10/3/1997 (23) | R | South Carolina |
| 51 | A. Al-Shaair Azeez Al-Shaair | OLB | 6-2 | 228 | 8/4/1997 (23) | 2 | Florida Atlantic |
| 45 | D. Flannigan-Fowles Demetrius Flannigan-Fowles | OLB | 6-2 | 210 | 9/4/1996 (24) | 1 | Arizona |
| 57 | D. Greenlaw Dre Greenlaw | OLB | 6-0 | 230 | 5/25/1997 (23) | 2 | Arkansas |
| 53 | M. Nzeocha Mark Nzeocha | OLB | 6-3 | 235 | 1/19/1990 (31) | 6 | Wyoming |
| 54 | F. Warner Fred Warner | MLB | 6-3 | 230 | 11/19/1996 (24) | 3 | BYU |
| 59 | J. Walker Joe Walker | LB | 6-2 | 236 | 12/11/1992 (28) | 5 | Oregon |
| 27 | D. Johnson Dontae Johnson | CB | 6-2 | 200 | 12/1/1991 (29) | 7 | NC State |
| 41 | E. Moseley Emmanuel Moseley | CB | 5-11 | 190 | 3/25/1996 (24) | 3 | Tennessee |
| 25 | R. Sherman Richard Sherman | CB | 6-3 | 205 | 3/30/1988 (32) | 10 | Stanford |
| 22 | J. Verrett Jason Verrett | CB | 5-10 | 188 | 6/18/1991 (29) | 7 | TCU |
| 24 | K. Williams K'Waun Williams | CB | 5-9 | 185 | 7/12/1991 (29) | 6 | Pittsburgh |
| 23 | A. Witherspoon Ahkello Witherspoon | CB | 6-3 | 195 | 3/21/1995 (25) | 4 | Colorado |
| 48 | K. Nacua Kai Nacua | DB | 6-0 | 205 | 3/3/1995 (25) | 3 | BYU |
| 20 | J. Ward Jimmie Ward | FS | 5-11 | 195 | 7/18/1991 (29) | 7 | Northern Illinois |
| 36 | M. Harris Marcell Harris | SS | 6-0 | 215 | 6/9/1994 (26) | 3 | Florida |
| 33 | T. Moore Tarvarius Moore | SS | 6-2 | 200 | 8/16/1996 (24) | 3 | Southern Miss |
Special Teams
| NO | Player | POS | HT | WT | DOB (AGE) | EXP | College |
|---|---|---|---|---|---|---|---|
| 6 | M. Wishnowsky Mitch Wishnowsky | P | 6-2 | 220 | 3/2/1992 (28) | 2 | Utah |