Player Bio
| HT/WT: 6-6, 308 lbs |
| Birthplace: Cincinnati, OH |
| Age: 24 |
| School: Illinois |
| Experience: R |
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11:0349ers vs. Seahawks Preview & Predictions | HQ NFL
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1:56Brock Purdy's MVP Pace Ahead of 49ers vs. Seahawks
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1:30
Brock Purdy Thriving Against the Blitz
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1:59Will Lack of RB Depth Hurt Seahawks vs. 49ers?
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1:06Should Brock Purdy Be MVP Favorite Ahead of Josh Allen?
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0:46Fantasy Football Week 5: Start Emanuel Wilson vs. 49ers
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0:36Fantasy Football Week 5: Sit Deebo Samuel at Seahawks
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1:29Seahawks Host Division Rival 49ers in Week 5
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1:32NFL Mock Trades: Josh Sweat to 49ers
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0:36
49ers vs. Seahawks: Battle for the NFC Top Spot
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1:19NFL Week 5 Picks: 49ers at Seahawks
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1:23Brock Purdy, 49ers Stay Undefeated Despite Injuries
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1:56Why the 4-0 49ers Don't Need to Lean on McCaffrey
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5:58REACTION: 49ers Outlast Broncos, Improve to 4-0 | HQ NFL
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0:38George Kittle Takes Screen Pass for 49ers Touchdown
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1:40Officially Delicious NFL Week 4 Best Bets
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1:31Carhartt Skilled Trades: Tyler Shough or Brock Purdy?
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2026 Defensive
| STATS |
CMB
Total Tackles
|
SCK
Sacks
|
FUM
Forced Fumbles
|
INT
Interceptions
|
TD
Interceptions Returned For Touchdown
|
|---|---|---|---|---|---|
| Regular Season | 4 | 0.0 | 0 | 0 | 0 |
Top James Thompson Jr. News
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49ers' James Thompson: Won't play against Seattle
Thompson (ankle) has been ruled out for Sunday's game against the Seahawks.
As expected, Thompson will miss a third consecutive game due to an ankle injury. He didn't practice once during Week 5 prep, so he'll need to return to the field to have a realistic shot of being available for Week 6 against the Commanders on Monday, Oct. 19. Naquan Jones and Sebastian Valdez will both see an uptick in rotational snaps at defensive tackle behind Osa Odighizuwa and Gracen Halton.
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49ers' James Thompson: Expects to be out again at Seattle
Coach Kyle Shanahan said Monday that Thompson (ankle) is not expected back for Week 5, Cam Inman of The San Jose Mercury News reports.
Thompson has already missed the 49ers' last two games with an ankle injury he picked up in Week 2 versus the Dolphins, and it seems like he's trending towards missing another contest come Sunday. In that case, Sebastian Valdez would be a candidate for increased snaps on the defensive line.
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49ers' James Thompson: Won't play Week 4
Thompson (ankle) won't play in San Francisco's Week 4 matchup versus the Broncos, Jennifer Lee Chan of NBC Sports Bay Area reports.
Thompson is in line to miss a second consecutive game due to the high-ankle sprain he suffered during the Week 2 win over the Dolphins. While there's currently no timetable for his return, his next chance to play will be the Week 6 matchup against Seattle.
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49ers' James Thompson: Sidelined versus Arizona
Thompson (ankle) is listed as out for Sunday's game against Arizona.
Thompson suffered a high-ankle sprain in the 35-13 victory over the Dolphins in Week 2. While nothing has been made official, an injury of this nature likely means he will miss more time moving ahead. The rookie appeared in both of the 49ers' games to begin the 2026 campaign, amassing four total tackles (one solo).
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49ers' James Thompson: Likely to miss action moving forward
Thompson suffered a high-ankle sprain during Sunday's 35-13 win over Miami, David Lombardi of SFStandard.com reports.
Thompson sustained the injury in the second half of the victory, and he will now likely be forced to miss some time moving forward. In his absence, the 49ers will have to add another interior defensive lineman to their active roster.
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49ers' James Thompson: Dealing with ankle injury
Thompson (ankle) is questionable to return to Sunday's contest against Miami, Eric Branch of the San Francisco Chronicle reports.
Thompson was slow to get up before ultimately going to the locker room in the second half. His status for the rest of the game is now in the air, but his absence won't have a major impact on the team's defensive approach.
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