Thompson (ankle) has been ruled out for Sunday's game against the Seahawks.
As expected, Thompson will miss a third consecutive game due to an ankle injury. He didn't practice once during Week 5 prep, so he'll need to return to the field to have a realistic shot of being available for Week 6 against the Commanders on Monday, Oct. 19. Naquan Jones and Sebastian Valdez will both see an uptick in rotational snaps at defensive tackle behind Osa Odighizuwa and Gracen Halton.
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49ers' James Thompson: Expects to be out again at Seattle
Rotowire
Coach Kyle Shanahan said Monday that Thompson (ankle) is not expected back for Week 5, Cam Inman of The San Jose Mercury News reports.
Thompson has already missed the 49ers' last two games with an ankle injury he picked up in Week 2 versus the Dolphins, and it seems like he's trending towards missing another contest come Sunday. In that case, Sebastian Valdez would be a candidate for increased snaps on the defensive line.
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49ers' James Thompson: Likely to miss action moving forward
Rotowire
Thompson suffered a high-ankle sprain during Sunday's 35-13 win over Miami, David Lombardi of SFStandard.com reports.
Thompson sustained the injury in the second half of the victory, and he will now likely be forced to miss some time moving forward. In his absence, the 49ers will have to add another interior defensive lineman to their active roster.
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49ers' James Thompson: Dealing with ankle injury
Rotowire
Thompson (ankle) is questionable to return to Sunday's contest against Miami, Eric Branch of the San Francisco Chronicle reports.
Thompson was slow to get up before ultimately going to the locker room in the second half. His status for the rest of the game is now in the air, but his absence won't have a major impact on the team's defensive approach.