Wednesday, September 30, 2020
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| M. Nzeocha Mark Nzeocha | OLB | Wed, Sep 30 | Quadriceps | IR. Injured Reserve. Expected Return - Week 7 |
Monday, September 28, 2020
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| J. Reed Jordan Reed | TE | Mon, Sep 28 | Knee | IR. Injured Reserve. Expected Return - Week 7 |
| K. Williams K'Waun Williams | CB | Mon, Sep 28 | Hip | Did Not Practice on Wednesday. Questionable for Week 4 vs. Philadelphia |
| J. Garoppolo Jimmy Garoppolo | QB | Mon, Sep 28 | Ankle | Did Not Practice on Wednesday. Questionable for Week 4 vs. Philadelphia |
| R. Mostert Raheem Mostert | RB | Mon, Sep 28 | Knee - MCL | Did Not Practice on Wednesday. Questionable for Week 4 vs. Philadelphia |
| D. Greenlaw Dre Greenlaw | OLB | Mon, Sep 28 | Quadriceps | Did Not Practice on Wednesday. Questionable for Week 4 vs. Philadelphia |
Sunday, September 27, 2020
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| E. Moseley Emmanuel Moseley | CB | Sun, Sep 27 | Concussion | Did Not Practice on Wednesday. Questionable for Week 4 vs. Philadelphia |
| T. Coleman Tevin Coleman | RB | Sun, Sep 27 | Knee | IR. Injured Reserve. Expected Return - Week 6 |
| D. Samuel Deebo Samuel | WR | Sun, Sep 27 | Foot | IR. Injured Reserve. Expected Return - Week 5 |
Wednesday, September 23, 2020
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| S. Thomas Solomon Thomas | DT | Wed, Sep 23 | Knee - ACL | IR. Injured Reserve |
| N. Bosa Nick Bosa | DE | Wed, Sep 23 | Knee - ACL | IR. Injured Reserve |
Friday, September 18, 2020
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| R. James Richie James | WR | Fri, Sep 18 | Hamstring | IR. Injured Reserve. Expected Return - Week 5 |
Thursday, September 17, 2020
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| R. Sherman Richard Sherman | CB | Thu, Sep 17 | Calf | IR. Injured Reserve. Expected Return - Week 5 |
Wednesday, September 9, 2020
| Player | Position | Updated | Injury | Injury Status |
|---|---|---|---|---|
| C. Thompson Chris Thompson | WR | Wed, Sep 9 | Undisclosed | IR. Injured Reserve |
| J. Taylor Jullian Taylor | DT | Wed, Sep 9 | Knee - ACL | Physically Unable to Perform. Expected Return - Week 8 |
| W. Richburg Weston Richburg | C | Wed, Sep 9 | Kneecap | Physically Unable to Perform. Expected Return - Week 8 |
| T. Austin Tavon Austin | WR | Wed, Sep 9 | Knee | IR. Injured Reserve. Expected Return - Week 4 |
| S. Coleman Shon Coleman | T | Wed, Sep 9 | Opt Out | Roster Exemption |
| R. Blair Ronald Blair | DE | Wed, Sep 9 | Knee - ACL | Physically Unable to Perform. Expected Return - Week 8 |
| J. Hurd Jalen Hurd | WR | Wed, Sep 9 | Knee - ACL | IR. Injured Reserve |