| All Quarterbacks vs Cardinals | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Rattler, Spencer, NO | 46 | 27 | 214 | 0 | 0 | 70.4 | 4 | 29 | 7.25 | 0 | 0 | 10 |
| 2 | Young, Bryce, CAR | 55 | 35 | 328 | 3 | 1 | 90.6 | 2 | 2 | 1.00 | 0 | 1 | 27 |
| 3 | Jones, Mac, SF | 41 | 27 | 284 | 1 | 1 | 83.8 | 1 | -1 | -1.00 | 0 | 0 | 15 |
| 4 | Darnold, Sam, SEA | 26 | 18 | 242 | 1 | 0 | 111.4 | 1 | 24 | 24.00 | 0 | 0 | 17 |
| 5 | Ward, Cam, TEN | 39 | 21 | 265 | 0 | 1 | 64.6 | 5 | -6 | -1.20 | 0 | 0 | 8 |
| 6 | Jones, Daniel, IND | 30 | 22 | 212 | 2 | 1 | 101.0 | 5 | 20 | 4.00 | 1 | 0 | 26 |
| 7 | Love, Jordan, GB | 29 | 19 | 179 | 1 | 0 | 93.9 | 4 | 22 | 5.50 | 0 | 0 | 15 |
| 9 | Prescott, Dak, DAL | 39 | 24 | 250 | 1 | 1 | 77.9 | 4 | 34 | 8.50 | 0 | 0 | 17 |
| 10 | Darnold, Sam, SEA | 12 | 10 | 178 | 1 | 1 | 111.8 | 3 | -2 | -0.67 | 0 | 2 | 7 |
| 10 | Lock, Drew, SEA | 0 | 0 | 0 | 0 | 0 | 0 | 4 | -4 | -1.00 | 0 | 0 | 0 |
| 11 | Purdy, Brock, SF | 26 | 19 | 200 | 3 | 0 | 133.5 | 1 | -7 | -7.00 | 0 | 0 | 26 |
| 11 | Jones, Mac, SF | 0 | 0 | 0 | 0 | 0 | 0 | 3 | -3 | -1.00 | 0 | 0 | 0 |
| 12 | Lawrence, Trevor, JAC | 30 | 18 | 256 | 3 | 3 | 81.4 | 5 | 29 | 5.80 | 0 | 1 | 22 |
| 13 | Mayfield, Baker, TB | 28 | 18 | 194 | 1 | 0 | 96.4 | 6 | 27 | 4.50 | 0 | 0 | 15 |
| 14 | Stafford, Matthew, LAR | 31 | 22 | 281 | 3 | 0 | 131.2 | 0 | 0 | 0 | 0 | 0 | 29 |
| 14 | Garoppolo, Jimmy, LAR | 0 | 0 | 0 | 0 | 0 | 0 | 3 | -4 | -1.33 | 0 | 0 | 0 |
| 15 | Stroud, C.J., HOU | 29 | 22 | 260 | 3 | 0 | 137.1 | 6 | 10 | 1.67 | 0 | 0 | 29 |
| 16 | Cousins, Kirk, ATL | 35 | 21 | 197 | 2 | 1 | 82.7 | 5 | -3 | -0.60 | 1 | 1 | 21 |