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Najee Harris RB | NYG
Giants' Najee Harris: Could poach snaps from Skattebo
Harris had a "pretty even split in reps" this week with starting running back Cam Skattebo and could be in store for more snaps and touches than usual in Sunday's game against the Saints, Dan Duggan of The Athletic reports.
Skattebo has served as the Giants' lead back through the first five games but is averaging just 3.6 yards per carry and has already fumbled four times (losing one). As a result of Skattebo's ongoing struggles, the Giants may be looking to scale back his workload to open up more work for the likes of Harris and Tyrone Tracy, the latter of whom has reclaimed duties as the team's preferred third-down back. Coming off an Achilles injury that cut short his 2025 campaign with the Chargers, Harris hasn't shown much explosiveness through his first four games in New York, averaging 3.6 yards per carry as well while being a relative non-factor in the passing game (one catch for five yards on one target). Even with the prospect of more touches in Week 6, Harris doesn't make for an attractive option in fantasy lineups.
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Cam Skattebo RB | NYG
Giants' Cam Skattebo: Could be headed for lighter workload
Skattebo had a "pretty even split in reps" this week with fellow running back Najee Harris and could be in store for fewer snaps and touches than usual in Sunday's game against the Saints, Dan Duggan of The Athletic reports.
Coming off a significant ankle injury that cut short his rookie season, Skattebo has handled a lead role out of the New York backfield through the first five games, playing no fewer than 57 percent of snaps on any occasion while averaging 18.2 touches per contest. The second-year back hasn't shown the same burst he displayed in 2025, however, averaging just 3.6 yards per carry and 7.9 yards per reception while finding the end zone only once. Perhaps more troublingly, Skattebo has struggled with ball security, fumbling four times and losing one. As a result of Skattebo's poor form to begin the season, the Giants may be compelled to lighten his workload Sunday and open up more opportunities for Harris compared to previous weeks.
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Will Campbell OT | NE
Patriots' Will Campbell: Looks likely to play Sunday
Campbell (knee), who is listed as questionable for Sunday's game against the Jets, is expected to play, Ian Rapoport of NFL Network reports.
After being diagnosed with an MCL sprain in his right knee following this past Sunday's win over the Raiders, Campbell appeared to be in danger of missing multiple games. Improbably, he was able to practice on a limited basis throughout the week and now appears likely to try and play through the injury Week 6. Campbell's status will be confirmed when the Patriots release their inactive list 90 minutes prior to the game's 1 p.m. ET kickoff.
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Joe Alt OT | LAC
Chargers' Joe Alt: Receives good news after checkup
Alt (neck), who has been ruled out for Sunday's game against the Chiefs, received favorable news after recently being evaluated by a specialist and is expected to ramp up his activity during the Chargers' Week 7 bye, Ian Rapoport of NFL Network reports.
Alt will be sidelined for a second straight game, but assuming his neck responds well while he begins ramping back up, he could be back in the lineup for the Chargers' next contest Week 8 versus the Rams on Nov. 1. Alex Harkey replaced Alt at right tackle in the Week 5 loss to the Broncos and could draw another start in his stead Sunday.
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Mason Graham DT | CLE
Browns' Mason Graham: Unlikely to suit up Sunday
Graham (knee/ankle), who is listed as questionable for Sunday's game against the Ravens, isn't expected to play, Mary Kay Cabot of The Cleveland Plain Dealer reports.
Graham was able to close Week 6 prep as a limited participant after missing practices Wednesday and Thursday, but he wasn't as stable during Friday's session as the Browns had hoped, per Cabot. As a result, Graham looks set to miss a second straight game due to an MCL sprain and an ankle sprain. Cleveland elevated defensive linemen Sam Kamara and Chris Williams from the practice squad Saturday, and both could be active Sunday to provide depth in the likely event Graham is sitting out.
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Jaylon Jones DB | JAC
Jaguars' Jaylon Jones: Missing another game
Jones (hamstring) is inactive for Sunday's game against the Texans in London.
Jones had been listed as questionable heading into the weekend but will be sidelined for a second straight game due to the hamstring injury after he managed only limited participation in practices Wednesday through Friday. The veteran cornerback is still waiting to make his 2026 debut since being signed to the Jaguars' 53-man roster earlier this month.
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Ja'Marcus Ingram CB | HOU
Texans' Ja'Marcus Ingram: Cleared for 2026 debut
Ingram (elbow) is active for Sunday's game against the Jaguars in London.
Listed as questionable heading into Sunday, Ingram had been expected to suit up against Jacksonville after he closed Week 6 prep with a pair of full practices before being officially reinstated from injured reserve Saturday. The 29-year-old will likely handle a depth role in the Houston secondary and will be featured on the special-teams units.
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Henry To'oTo'o LB | HOU
Texans' Henry To'oTo'o: Back in action in Week 6
To'oTo'o (shoulder) is active for Sunday's game against the Jaguars in London.
The 25-year-old linebacker had been listed as questionable heading into Sunday's contest, but after being activated from injured reserve Saturday, the writing was on the wall for him to suit up in London. To'oTo'o will be suiting up for the first time since the Texans' Week 1 loss to the Bills, when he exited in the fourth quarter after injuring his shoulder.
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Pat Freiermuth TE | PIT
Steelers' Pat Freiermuth: Chance to play in Week 6
The Steelers are "optimistic" that Freiermuth (calf) will play Sunday at Tampa Bay, Ian Rapoport of NFL Network reports.
Pittsburgh added Freiermuth to the injury report Saturday, listing him as questionable for Week 6 action due to a calf injury. Despite the very late decision to do so, the team seemingly is of the belief that he'll be available Sunday, which will be confirmed approximately 90 minutes before a 1:00 p.m. ET kickoff. If Freiermuth isn't 100 percent, Darnell Washington and Robert Tonyan will be on hand for increased roles at tight end.
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Marvin Harrison Jr. WR | HOU
Texans' Marvin Harrison: Confirmed for team debut Sunday
Harrison is active for Sunday's game against the Jaguars in London.
Just as head coach DeMeco Ryans indicated would be the case earlier in the week, Harrison will be cleared to make his Texans debut right away after being acquired from the Cardinals on Monday. Since he hasn't had much time to get up to speed with his new playbook, Harrison is expected to be eased into the mix Sunday with a light snap count, per Cameron Wolfe of NFL Network. Eventually, the No. 4 overall pick in the 2024 NFL Draft could settle in as the Texans' No. 2 wideout behind Nico Collins.