| All Quarterbacks vs Bills | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Jackson, Lamar, BAL | 19 | 14 | 209 | 2 | 0 | 144.4 | 6 | 70 | 11.67 | 1 | 0 | 33 |
| 2 | Taylor, Tyrod, NYJ | 11 | 7 | 56 | 1 | 0 | 106.6 | 3 | 21 | 7.00 | 0 | 0 | 10 |
| 2 | Fields, Justin, NYJ | 11 | 3 | 27 | 0 | 0 | 39.6 | 5 | 49 | 9.80 | 0 | 1 | 3 |
| 3 | Tagovailoa, Tua, MIA | 34 | 22 | 146 | 2 | 1 | 81.2 | 2 | 10 | 5.00 | 0 | 0 | 16 |
| 4 | Rattler, Spencer, NO | 27 | 18 | 126 | 1 | 0 | 89.4 | 6 | 49 | 8.17 | 0 | 0 | 15 |
| 5 | Maye, Drake, NE | 30 | 22 | 273 | 0 | 0 | 101.1 | 3 | 12 | 4.00 | 0 | 0 | 11 |
| 6 | Penix Jr., Michael, ATL | 32 | 20 | 250 | 1 | 0 | 97.1 | 2 | 6 | 3.00 | 0 | 0 | 16 |
| 8 | Dalton, Andy, CAR | 24 | 16 | 175 | 0 | 1 | 70.7 | 2 | 1 | 0.50 | 0 | 2 | 1 |
| 9 | Mahomes, Patrick, KC | 34 | 15 | 250 | 0 | 1 | 57.2 | 1 | 5 | 5.00 | 0 | 0 | 10 |
| 10 | Tagovailoa, Tua, MIA | 21 | 15 | 173 | 2 | 2 | 88.1 | 2 | -1 | -0.50 | 0 | 0 | 14 |
| 11 | Mayfield, Baker, TB | 28 | 16 | 173 | 1 | 1 | 72.5 | 5 | 39 | 7.80 | 1 | 1 | 17 |
| 11 | Bridgewater, Teddy, TB | 0 | 0 | 0 | 0 | 0 | 0 | 1 | -1 | -1.00 | 0 | 0 | 0 |
| 12 | Mills, Davis, HOU | 30 | 16 | 153 | 2 | 0 | 90.0 | 2 | 4 | 2.00 | 0 | 0 | 18 |
| 13 | Rodgers, Aaron, PIT | 21 | 10 | 117 | 0 | 0 | 65.0 | 1 | 0 | 0.00 | 0 | 1 | 2 |
| 13 | Rudolph, Mason, PIT | 3 | 0 | 0 | 0 | 1 | 0.0 | 0 | 0 | 0 | 0 | 0 | -2 |
| 14 | Burrow, Joe, CIN | 36 | 25 | 284 | 4 | 2 | 106.7 | 0 | 0 | 0 | 0 | 0 | 31 |