| All Quarterbacks vs Bills | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Jackson, Lamar, BAL | 19 | 14 | 209 | 2 | 0 | 144.4 | 6 | 70 | 11.67 | 1 | 0 | 33 |
| 2 | Taylor, Tyrod, NYJ | 11 | 7 | 56 | 1 | 0 | 106.6 | 3 | 21 | 7.00 | 0 | 0 | 10 |
| 2 | Fields, Justin, KC | 11 | 3 | 27 | 0 | 0 | 39.6 | 5 | 49 | 9.80 | 0 | 1 | 3 |
| 3 | Tagovailoa, Tua, ATL | 34 | 22 | 146 | 2 | 1 | 81.2 | 2 | 10 | 5.00 | 0 | 0 | 16 |
| 4 | Rattler, Spencer, NO | 27 | 18 | 126 | 1 | 0 | 89.4 | 6 | 49 | 8.17 | 0 | 0 | 15 |
| 5 | Maye, Drake, NE | 30 | 22 | 273 | 0 | 0 | 101.1 | 3 | 12 | 4.00 | 0 | 0 | 11 |
| 6 | Penix Jr., Michael, ATL | 32 | 20 | 250 | 1 | 0 | 97.1 | 2 | 6 | 3.00 | 0 | 0 | 16 |
| 8 | Dalton, Andy, PHI | 24 | 16 | 175 | 0 | 1 | 70.7 | 2 | 1 | 0.50 | 0 | 2 | 1 |
| 9 | Mahomes, Patrick, KC | 34 | 15 | 250 | 0 | 1 | 57.2 | 1 | 5 | 5.00 | 0 | 0 | 10 |
| 10 | Tagovailoa, Tua, ATL | 21 | 15 | 173 | 2 | 2 | 88.1 | 2 | -1 | -0.50 | 0 | 0 | 14 |
| 11 | Mayfield, Baker, TB | 28 | 16 | 173 | 1 | 1 | 72.5 | 5 | 39 | 7.80 | 1 | 1 | 17 |
| 11 | Bridgewater, Teddy, DET | 0 | 0 | 0 | 0 | 0 | 0 | 1 | -1 | -1.00 | 0 | 0 | 0 |
| 12 | Mills, Davis, HOU | 30 | 16 | 153 | 2 | 0 | 90.0 | 2 | 4 | 2.00 | 0 | 0 | 18 |
| 13 | Rodgers, Aaron, PIT | 21 | 10 | 117 | 0 | 0 | 65.0 | 1 | 0 | 0.00 | 0 | 1 | 2 |
| 13 | Rudolph, Mason, PIT | 3 | 0 | 0 | 0 | 1 | 0.0 | 0 | 0 | 0 | 0 | 0 | -2 |
| 14 | Burrow, Joe, CIN | 36 | 25 | 284 | 4 | 2 | 106.7 | 0 | 0 | 0 | 0 | 0 | 31 |
| 15 | Maye, Drake, NE | 23 | 14 | 155 | 0 | 1 | 62.8 | 4 | 43 | 10.75 | 2 | 0 | 20 |
| 16 | Sanders, Shedeur, CLE | 29 | 20 | 157 | 1 | 2 | 64.9 | 4 | 49 | 12.25 | 0 | 0 | 12 |
| 17 | Hurts, Jalen, PHI | 27 | 13 | 110 | 1 | 0 | 71.5 | 3 | 5 | 1.67 | 0 | 0 | 10 |
| 18 | Cook, Brady, NYJ | 22 | 11 | 60 | 1 | 0 | 71.4 | 3 | 7 | 2.33 | 0 | 0 | 10 |
| 19 | Lawrence, Trevor, JAC | 30 | 18 | 207 | 3 | 2 | 86.4 | 6 | 31 | 5.17 | 0 | 0 | 25 |
| 20 | Nix, Bo, DEN | 46 | 26 | 279 | 3 | 1 | 87.1 | 12 | 29 | 2.42 | 0 | 0 | 29 |