| All Quarterbacks vs Bills | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Stroud, C.J., HOU | 38 | 26 | 274 | 2 | 0 | 106.7 | 2 | 15 | 7.50 | 0 | 2 | 19 |
| 2 | Goff, Jared, DET | 38 | 26 | 327 | 4 | 0 | 130.0 | 3 | 7 | 2.33 | 0 | 0 | 37 |
| 3 | Herbert, Justin, LAC | 34 | 20 | 226 | 1 | 1 | 76.3 | 4 | 17 | 4.25 | 0 | 0 | 14 |
| 4 | Maye, Drake, NE | 37 | 22 | 269 | 3 | 1 | 97.7 | 8 | 54 | 6.75 | 0 | 1 | 31 |
| 5 | Stafford, Matthew, LAR | 54 | 40 | 383 | 3 | 0 | 111.9 | 0 | 0 | 0 | 0 | 0 | 33 |
| 6 | Cousins, Kirk, LV | 41 | 23 | 313 | 2 | 1 | 86.7 | 0 | 0 | 0 | 0 | 0 | 22 |
| 8 | Jackson, Lamar, BAL | 1 | 0 | 0 | 0 | 0 | 39.6 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8 | Fagnano, Joe, BAL | 21 | 10 | 91 | 0 | 1 | 40.0 | 3 | 3 | 1.00 | 0 | 1 | -1 |
| 8 | Huntley, Tyler, BAL | 4 | 2 | 0 | 0 | 0 | 56.2 | 0 | 0 | 0 | 0 | 1 | -2 |
| 9 | Brosmer, Max, MIN | 7 | 6 | 58 | 0 | 0 | 101.2 | 0 | 0 | 0 | 0 | 0 | 2 |
| 9 | Wentz, Carson, MIN | 25 | 8 | 81 | 0 | 2 | 8.9 | 1 | 0 | 0.00 | 0 | 1 | -3 |