| All Quarterbacks vs Bills | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Stroud, C.J., HOU | 38 | 26 | 274 | 2 | 0 | 106.7 | 2 | 15 | 7.50 | 0 | 2 | 19 |
| 2 | Goff, Jared, DET | 38 | 26 | 327 | 4 | 0 | 130.0 | 3 | 7 | 2.33 | 0 | 0 | 37 |
| 3 | Herbert, Justin, LAC | 34 | 20 | 226 | 1 | 1 | 76.3 | 4 | 17 | 4.25 | 0 | 0 | 14 |
| 4 | Maye, Drake, NE | 37 | 22 | 269 | 3 | 1 | 97.7 | 8 | 54 | 6.75 | 0 | 1 | 31 |
| 5 | Stafford, Matthew, LAR | 54 | 40 | 383 | 3 | 0 | 111.9 | 0 | 0 | 0 | 0 | 0 | 33 |
| 6 | Cousins, Kirk, LV | 41 | 23 | 313 | 2 | 1 | 86.7 | 0 | 0 | 0 | 0 | 0 | 22 |