| All Quarterbacks vs Colts | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Jackson, Lamar, BAL | 25 | 17 | 324 | 1 | 0 | 124.2 | 7 | 40 | 5.71 | 1 | 1 | 26 |
| 2 | Mahomes, Patrick, KC | 47 | 32 | 382 | 3 | 0 | 114.0 | 2 | 17 | 8.50 | 0 | 0 | 34 |
| 3 | Stroud, C.J., HOU | 27 | 16 | 167 | 1 | 0 | 89.6 | 2 | 10 | 5.00 | 0 | 0 | 13 |
| 4 | Kaliakmanis, Athan, WAS | 33 | 15 | 186 | 1 | 1 | 60.9 | 3 | 16 | 5.33 | 0 | 0 | 12 |
| 4 | Mariota, Marcus, WAS | 4 | 3 | 46 | 0 | 0 | 112.5 | 1 | 35 | 35.00 | 0 | 0 | 4 |
| 5 | Rodgers, Aaron, PIT | 31 | 22 | 235 | 3 | 0 | 125.1 | 1 | 6 | 6.00 | 0 | 0 | 27 |
| 5 | Rudolph, Mason, PIT | 0 | 0 | 0 | 0 | 0 | 0 | 2 | -2 | -1.00 | 0 | 0 | 0 |
| 6 | Ward, Cam, TEN | 22 | 11 | 102 | 1 | 1 | 59.3 | 3 | 7 | 2.33 | 0 | 0 | 8 |
| 7 | Murray, Kyler, MIN | 24 | 14 | 150 | 1 | 0 | 90.6 | 5 | 39 | 7.80 | 0 | 0 | 15 |
| 8 | Lawrence, Trevor, JAC | 14 | 10 | 210 | 3 | 0 | 153.3 | 3 | 10 | 3.33 | 0 | 1 | 25 |
| 8 | Ewers, Quinn, MIA | 3 | 1 | 8 | 0 | 0 | 42.4 | 0 | 0 | 0 | 0 | 0 | 0 |
| 9 | Prescott, Dak, DAL | 34 | 21 | 335 | 2 | 0 | 114.2 | 2 | 1 | 0.50 | 0 | 1 | 23 |