| All Quarterbacks vs Colts | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Tagovailoa, Tua, MIA | 23 | 14 | 114 | 1 | 2 | 51.7 | 1 | 7 | 7.00 | 0 | 1 | 6 |
| 1 | Wilson, Zach, MIA | 8 | 5 | 32 | 0 | 0 | 70.8 | 1 | 3 | 3.00 | 0 | 0 | 1 |
| 2 | Nix, Bo, DEN | 30 | 22 | 206 | 3 | 1 | 111.2 | 3 | 20 | 6.67 | 0 | 0 | 26 |
| 3 | Ward, Cam, TEN | 38 | 23 | 219 | 1 | 1 | 74.3 | 3 | 12 | 4.00 | 0 | 0 | 13 |
| 4 | Stafford, Matthew, LAR | 41 | 29 | 375 | 3 | 0 | 123.5 | 4 | 4 | 1.00 | 0 | 0 | 33 |
| 5 | Smith, Geno, LV | 36 | 25 | 228 | 0 | 2 | 63.2 | 3 | 8 | 2.67 | 0 | 0 | 5 |
| 6 | Brissett, Jacoby, ARI | 44 | 27 | 320 | 2 | 1 | 89.2 | 3 | 19 | 6.33 | 0 | 0 | 23 |
| 7 | Herbert, Justin, LAC | 55 | 37 | 420 | 3 | 2 | 93.0 | 6 | 31 | 5.17 | 0 | 0 | 33 |
| 8 | Ward, Cam, TEN | 38 | 22 | 259 | 1 | 1 | 76.5 | 2 | 4 | 2.00 | 0 | 0 | 14 |
| 9 | Rodgers, Aaron, PIT | 35 | 25 | 203 | 1 | 0 | 95.3 | 2 | 0 | 0.00 | 0 | 0 | 14 |
| 10 | Penix Jr., Michael, ATL | 28 | 12 | 177 | 1 | 0 | 76.0 | 1 | -1 | -1.00 | 0 | 1 | 13 |
| 12 | Mahomes, Patrick, KC | 46 | 29 | 352 | 0 | 1 | 77.4 | 4 | 30 | 7.50 | 0 | 0 | 17 |
| 13 | Stroud, C.J., HOU | 35 | 22 | 276 | 0 | 1 | 75.4 | 1 | 0 | 0.00 | 0 | 0 | 9 |
| 14 | Lawrence, Trevor, JAC | 30 | 17 | 244 | 2 | 0 | 105.4 | 4 | 16 | 4.00 | 0 | 0 | 22 |
| 14 | Mullens, Nick, JAC | 1 | 1 | 3 | 0 | 0 | 79.2 | 3 | -1 | -0.33 | 0 | 0 | 0 |
| 15 | Darnold, Sam, SEA | 36 | 22 | 271 | 0 | 0 | 84.4 | 4 | 5 | 1.25 | 0 | 0 | 10 |
| 16 | Purdy, Brock, SF | 34 | 25 | 295 | 5 | 1 | 126.8 | 2 | 11 | 5.50 | 0 | 0 | 40 |
| 16 | Jones, Mac, SF | 0 | 0 | 0 | 0 | 0 | 0 | 3 | -3 | -1.00 | 0 | 0 | 0 |