| All Quarterbacks vs Chargers | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Brissett, Jacoby, ARI | 37 | 27 | 277 | 1 | 0 | 103.1 | 6 | 14 | 2.33 | 0 | 0 | 18 |
| 2 | Cousins, Kirk, LV | 29 | 19 | 253 | 3 | 1 | 113.1 | 4 | 1 | 0.25 | 0 | 0 | 26 |
| 3 | Allen, Josh, BUF | 26 | 16 | 204 | 0 | 2 | 54.0 | 8 | 22 | 2.75 | 2 | 1 | 16 |
| 4 | Darnold, Sam, SEA | 22 | 13 | 168 | 2 | 1 | 94.5 | 3 | 6 | 2.00 | 0 | 0 | 16 |
| 5 | Nix, Bo, DEN | 27 | 16 | 123 | 1 | 0 | 82.8 | 4 | 10 | 2.50 | 0 | 1 | 9 |
| 6 | Mahomes, Patrick, KC | 30 | 23 | 272 | 0 | 1 | 89.9 | 5 | 16 | 3.20 | 0 | 0 | 9 |
| 8 | Stafford, Matthew, LAR | 25 | 17 | 157 | 1 | 1 | 81.6 | 0 | 0 | 0 | 0 | 0 | 10 |
| 9 | Stroud, C.J., HOU | 35 | 21 | 384 | 5 | 1 | 125.5 | 2 | 20 | 10.00 | 0 | 0 | 45 |
| 9 | Mills, Davis, HOU | 2 | 1 | 7 | 0 | 0 | 58.3 | 2 | -2 | -1.00 | 0 | 0 | 0 |