| All Quarterbacks vs Saints | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Murray, Kyler, ARI | 29 | 21 | 163 | 2 | 0 | 108.8 | 7 | 38 | 5.43 | 0 | 0 | 21 |
| 2 | Jones, Mac, SF | 39 | 26 | 279 | 3 | 0 | 113.1 | 6 | 6 | 1.00 | 0 | 1 | 27 |
| 3 | Darnold, Sam, SEA | 18 | 14 | 218 | 2 | 0 | 154.2 | 0 | 0 | 0 | 0 | 0 | 20 |
| 3 | Milroe, Jalen, SEA | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3.00 | 0 | 0 | 0 |
| 3 | Lock, Drew, SEA | 3 | 2 | 15 | 0 | 0 | 78.5 | 1 | -1 | -1.00 | 0 | 0 | 0 |
| 4 | Allen, Josh, BUF | 22 | 16 | 209 | 2 | 1 | 113.6 | 7 | 45 | 6.43 | 1 | 0 | 28 |
| 5 | Dart, Jaxson, NYG | 40 | 26 | 202 | 2 | 2 | 73.1 | 7 | 55 | 7.86 | 0 | 1 | 19 |
| 6 | Maye, Drake, NE | 26 | 18 | 261 | 3 | 0 | 140.1 | 9 | 28 | 3.11 | 0 | 0 | 32 |
| 7 | Williams, Caleb, CHI | 26 | 15 | 172 | 0 | 1 | 61.7 | 4 | -2 | -0.50 | 0 | 0 | 4 |
| 8 | Mayfield, Baker, TB | 24 | 15 | 152 | 0 | 0 | 80.6 | 0 | 0 | 0 | 0 | 1 | 4 |
| 9 | Stafford, Matthew, LAR | 32 | 24 | 281 | 4 | 0 | 140.8 | 4 | -4 | -1.00 | 0 | 0 | 35 |
| 10 | Young, Bryce, CAR | 25 | 17 | 124 | 0 | 1 | 62.8 | 2 | 6 | 3.00 | 0 | 1 | 0 |
| 12 | Cousins, Kirk, ATL | 23 | 16 | 199 | 2 | 1 | 107.0 | 2 | 5 | 2.50 | 0 | 0 | 17 |
| 13 | Tagovailoa, Tua, MIA | 23 | 12 | 157 | 0 | 1 | 55.9 | 4 | 4 | 1.00 | 0 | 0 | 4 |
| 14 | Mayfield, Baker, TB | 30 | 14 | 122 | 1 | 1 | 55.1 | 6 | 42 | 7.00 | 0 | 0 | 12 |