| All Quarterbacks vs 49ers | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Darnold, Sam, SEA | 23 | 16 | 150 | 0 | 0 | 87.2 | 2 | 14 | 7.00 | 0 | 1 | 5 |
| 1 | Milroe, Jalen, SEA | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1.00 | 0 | 0 | 0 |
| 2 | Rattler, Spencer, NO | 34 | 25 | 207 | 3 | 0 | 118.1 | 4 | 14 | 3.50 | 0 | 0 | 27 |
| 3 | Murray, Kyler, ARI | 35 | 22 | 159 | 1 | 0 | 82.9 | 6 | 37 | 6.17 | 0 | 0 | 15 |
| 4 | Lawrence, Trevor, JAC | 31 | 21 | 174 | 1 | 0 | 92.7 | 7 | 7 | 1.00 | 0 | 0 | 12 |
| 5 | Stafford, Matthew, LAR | 47 | 30 | 389 | 3 | 0 | 111.0 | 1 | 0 | 0.00 | 0 | 1 | 31 |
| 6 | Mayfield, Baker, TB | 23 | 17 | 256 | 2 | 0 | 139.0 | 3 | 14 | 4.67 | 0 | 0 | 23 |
| 7 | Penix Jr., Michael, ATL | 38 | 21 | 241 | 1 | 0 | 83.3 | 2 | 6 | 3.00 | 0 | 1 | 13 |
| 8 | Stroud, C.J., HOU | 39 | 30 | 318 | 2 | 1 | 106.6 | 7 | 30 | 4.29 | 0 | 0 | 25 |
| 9 | Dart, Jaxson, NYG | 33 | 24 | 191 | 2 | 0 | 107.0 | 8 | 56 | 7.00 | 1 | 0 | 30 |
| 10 | Stafford, Matthew, LAR | 36 | 24 | 280 | 4 | 0 | 127.1 | 3 | -3 | -1.00 | 0 | 0 | 35 |
| 11 | Brissett, Jacoby, ARI | 57 | 47 | 452 | 2 | 2 | 96.8 | 2 | -2 | -1.00 | 0 | 0 | 26 |
| 12 | Young, Bryce, CAR | 29 | 18 | 169 | 1 | 2 | 60.8 | 4 | 15 | 3.75 | 0 | 0 | 9 |
| 13 | Sanders, Shedeur, CLE | 25 | 16 | 149 | 1 | 0 | 93.6 | 1 | 6 | 6.00 | 0 | 0 | 11 |
| 13 | Gabriel, Dillon, CLE | 1 | 1 | 0 | 0 | 0 | 79.2 | 0 | 0 | 0 | 0 | 0 | 0 |
| 15 | Ward, Cam, TEN | 29 | 18 | 170 | 2 | 0 | 101.2 | 1 | 2 | 2.00 | 0 | 0 | 18 |
| 16 | Rivers, Philip, IND | 35 | 23 | 277 | 2 | 1 | 97.0 | 0 | 0 | 0 | 0 | 0 | 21 |
| 16 | Leonard, Riley, IND | 1 | 0 | 0 | 0 | 0 | 39.6 | 0 | 0 | 0 | 0 | 0 | 0 |