| All Quarterbacks vs 49ers | |||||||||||||
| Passing | Rushing | ||||||||||||
| Week | Player | Att | Cmp | Yd | TD | Int | Rate | Att | Yd | Avg | TD | FL | FPTS |
| 1 | Stafford, Matthew, LAR | 25 | 15 | 155 | 0 | 1 | 61.2 | 2 | -1 | -0.50 | 0 | 0 | 4 |
| 1 | Bennett, Stetson, LAR | 3 | 2 | 13 | 0 | 0 | 75.7 | 1 | 9 | 9.00 | 0 | 0 | 0 |
| 2 | Willis, Malik, MIA | 23 | 14 | 197 | 1 | 0 | 103.0 | 2 | 6 | 3.00 | 0 | 0 | 13 |
| 3 | Brissett, Jacoby, ARI | 52 | 38 | 280 | 2 | 0 | 98.2 | 4 | 4 | 1.00 | 1 | 0 | 29 |
| 4 | Nix, Bo, DEN | 42 | 25 | 214 | 1 | 0 | 80.9 | 2 | 10 | 5.00 | 0 | 0 | 15 |
| 5 | Darnold, Sam, SEA | 29 | 18 | 195 | 1 | 2 | 64.6 | 1 | 5 | 5.00 | 0 | 0 | 9 |
| 6 | Daniels, Jayden, WAS | 40 | 29 | 300 | 2 | 0 | 110.4 | 4 | 10 | 2.50 | 0 | 0 | 25 |
| 7 | Penix Jr., Michael, ATL | 34 | 25 | 213 | 3 | 0 | 118.9 | 5 | -1 | -0.20 | 0 | 0 | 26 |
| 9 | Cousins, Kirk, LV | 32 | 22 | 216 | 1 | 3 | 58.9 | 2 | 0 | 0.00 | 1 | 0 | 14 |