| All Running Backs vs Cardinals | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Kamara, Alvin, NO | 11 | 45 | 4.09 | 1 | 2 | 2 | 12 | 6.00 | 0 | 0 | 11 |
| 1 | Miller, Kendre, NO | 5 | 24 | 4.80 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 1 | Neal, Devin, NO | 2 | 9 | 4.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2 | Hubbard, Chuba, CAR | 10 | 38 | 3.80 | 0 | 6 | 5 | 39 | 7.80 | 1 | 0 | 12 |
| 2 | Dowdle, Rico, CAR | 6 | 9 | 1.50 | 0 | 1 | 1 | 10 | 10.00 | 0 | 0 | 1 |
| 2 | Etienne, Trevor, CAR | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 2.00 | 0 | 0 | 0 |
| 3 | McCaffrey, Christian, SF | 17 | 52 | 3.06 | 0 | 15 | 10 | 88 | 8.80 | 0 | 0 | 13 |
| 3 | Juszczyk, Kyle, SF | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1.00 | 1 | 0 | 6 |
| 3 | Robinson Jr., Brian, SF | 2 | 22 | 11.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 4 | Walker III, Kenneth, SEA | 19 | 81 | 4.26 | 0 | 2 | 1 | 29 | 29.00 | 0 | 0 | 10 |
| 4 | Charbonnet, Zach, SEA | 12 | 39 | 3.25 | 1 | 2 | 2 | 5 | 2.50 | 0 | 0 | 9 |
| 5 | Pollard, Tony, TEN | 14 | 67 | 4.79 | 1 | 3 | 3 | 11 | 3.67 | 0 | 1 | 11 |
| 5 | Spears, Tyjae, TEN | 4 | 14 | 3.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 5 | Chestnut, Julius, TEN | 1 | 3 | 3.00 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 6 | Taylor, Jonathan, IND | 21 | 123 | 5.86 | 1 | 4 | 4 | 14 | 3.50 | 0 | 0 | 19 |
| 6 | Abdullah, Ameer, IND | 1 | 7 | 7.00 | 0 | 1 | 1 | 9 | 9.00 | 0 | 0 | 0 |
| 7 | Jacobs, Josh, GB | 13 | 55 | 4.23 | 2 | 1 | 1 | 3 | 3.00 | 0 | 0 | 17 |
| 7 | Wilson, Emanuel, GB | 6 | 17 | 2.83 | 0 | 1 | 1 | -2 | -2.00 | 0 | 0 | 1 |
| 9 | Williams, Javonte, DAL | 15 | 83 | 5.53 | 0 | 1 | 1 | 0 | 0.00 | 0 | 1 | 6 |
| 9 | Davis, Malik, DAL | 1 | 3 | 3.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 10 | Charbonnet, Zach, SEA | 14 | 83 | 5.93 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 14 |
| 10 | Holani, George, SEA | 7 | 31 | 4.43 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 9 |
| 10 | Walker III, Kenneth, SEA | 14 | 67 | 4.79 | 0 | 1 | 1 | 3 | 3.00 | 0 | 0 | 6 |
| 11 | McCaffrey, Christian, SF | 13 | 81 | 6.23 | 2 | 6 | 5 | 40 | 8.00 | 1 | 0 | 30 |
| 11 | Juszczyk, Kyle, SF | 0 | 0 | 0 | 0 | 2 | 2 | 26 | 13.00 | 0 | 0 | 2 |
| 11 | Robinson Jr., Brian, SF | 8 | 24 | 3.00 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 |
| 12 | Etienne, Travis, JAC | 15 | 86 | 5.73 | 0 | 4 | 3 | 30 | 10.00 | 1 | 0 | 17 |
| 12 | Tuten, Bhayshul, JAC | 7 | 17 | 2.43 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
| 12 | Allen, LeQuint, JAC | 1 | 2 | 2.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 13 | Irving, Bucky, TB | 17 | 61 | 3.59 | 1 | 2 | 2 | 20 | 10.00 | 0 | 0 | 14 |
| 13 | White, Rachaad, TB | 2 | 7 | 3.50 | 0 | 3 | 3 | 22 | 7.33 | 0 | 0 | 2 |
| 13 | Tucker, Sean, TB | 2 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 14 | Corum, Blake, LAR | 12 | 128 | 10.67 | 2 | 1 | 1 | 3 | 3.00 | 0 | 0 | 24 |
| 14 | Williams, Kyren, LAR | 13 | 84 | 6.46 | 1 | 2 | 2 | 13 | 6.50 | 0 | 0 | 15 |
| 14 | Rivers, Ronnie, LAR | 8 | 41 | 5.12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| 15 | Jordan, Jawhar, HOU | 15 | 101 | 6.73 | 0 | 2 | 2 | 17 | 8.50 | 0 | 0 | 11 |
| 15 | Marks, Woody, HOU | 7 | 30 | 4.29 | 0 | 1 | 1 | 8 | 8.00 | 0 | 0 | 3 |
| 15 | Ogunbowale, Dare, HOU | 5 | 2 | 0.40 | 0 | 4 | 3 | 32 | 10.67 | 0 | 0 | 3 |
| 16 | Robinson, Bijan, ATL | 16 | 76 | 4.75 | 0 | 11 | 7 | 92 | 13.14 | 1 | 0 | 22 |
| 16 | Allgeier, Tyler, ATL | 16 | 79 | 4.94 | 0 | 1 | 1 | -6 | -6.00 | 0 | 0 | 7 |