| All Running Backs vs Cardinals | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Robinson Jr., Brian, WAS | 19 | 59 | 3.11 | 0 | 2 | 1 | 7 | 7.00 | 1 | 0 | 11 |
| 1 | Rodriguez Jr., Chris, WAS | 3 | 7 | 2.33 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 1 | Gibson, Antonio, NE | 3 | 9 | 3.00 | 0 | 1 | 1 | 10 | 10.00 | 0 | 1 | -1 |
| 2 | Barkley, Saquon, PHI | 17 | 63 | 3.71 | 1 | 7 | 6 | 29 | 4.83 | 1 | 0 | 20 |
| 2 | Breida, Matt, NYG | 1 | 5 | 5.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3 | Pollard, Tony, TEN | 23 | 122 | 5.30 | 0 | 3 | 3 | -1 | -0.33 | 0 | 0 | 12 |
| 3 | Dowdle, Rico, DAL | 4 | 21 | 5.25 | 0 | 3 | 3 | 25 | 8.33 | 1 | 0 | 10 |
| 3 | Luepke, Hunter, DAL | 1 | 9 | 9.00 | 0 | 1 | 1 | 12 | 12.00 | 0 | 0 | 1 |
| 4 | McCaffrey, Christian, SF | 20 | 106 | 5.30 | 3 | 8 | 7 | 71 | 10.14 | 1 | 0 | 41 |
| 4 | Mason, Jordan, SF | 3 | 10 | 3.33 | 0 | 1 | 1 | 13 | 13.00 | 0 | 0 | 2 |
| 4 | Juszczyk, Kyle, SF | 2 | 3 | 1.50 | 0 | 1 | 1 | 4 | 4.00 | 0 | 0 | 0 |
| 5 | Mixon, Joe, HOU | 25 | 81 | 3.24 | 0 | 4 | 4 | 13 | 3.25 | 0 | 0 | 9 |
| 5 | Brown, Chase, CIN | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 2.00 | 0 | 0 | 0 |
| 5 | Williams, Trayveon, CIN | 1 | 5 | 5.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 6 | Williams, Kyren, LAR | 20 | 158 | 7.90 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 21 |
| 6 | Evans, Zach, LAR | 4 | 10 | 2.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 6 | Rivers, Ronnie, LAR | 3 | 9 | 3.00 | 0 | 1 | 1 | 4 | 4.00 | 0 | 0 | 0 |
| 7 | Walker III, Kenneth, SEA | 26 | 105 | 4.04 | 0 | 3 | 2 | 6 | 3.00 | 0 | 0 | 10 |
| 7 | Dallas, DeeJay, ARI | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0.00 | 0 | 1 | -2 |
| 8 | Edwards, Gus, LAC | 19 | 80 | 4.21 | 3 | 2 | 2 | 14 | 7.00 | 0 | 0 | 27 |
| 8 | Hill, Justice, BAL | 4 | 15 | 3.75 | 0 | 4 | 4 | 40 | 10.00 | 0 | 0 | 5 |
| 9 | Hunt, Kareem, CLE | 14 | 38 | 2.71 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 9 |
| 9 | Ford, Jerome, CLE | 20 | 44 | 2.20 | 0 | 7 | 5 | 33 | 6.60 | 0 | 0 | 7 |
| 9 | Strong Jr., Pierre, CLE | 3 | 9 | 3.00 | 0 | 1 | 1 | -7 | -7.00 | 0 | 0 | 0 |
| 10 | Robinson, Bijan, ATL | 22 | 95 | 4.32 | 1 | 2 | 1 | 11 | 11.00 | 0 | 0 | 16 |
| 10 | Allgeier, Tyler, ATL | 9 | 31 | 3.44 | 0 | 1 | 1 | 7 | 7.00 | 0 | 0 | 3 |
| 10 | Patterson, Cordarrelle, PIT | 3 | 13 | 4.33 | 0 | 2 | 2 | 7 | 3.50 | 0 | 0 | 1 |
| 11 | Singletary, Devin, NYG | 22 | 112 | 5.09 | 1 | 2 | 2 | 6 | 3.00 | 0 | 0 | 17 |
| 11 | Boone, Mike, CAR | 1 | 0 | 0.00 | 0 | 1 | 1 | 5 | 5.00 | 0 | 0 | 0 |
| 12 | Williams, Kyren, LAR | 16 | 143 | 8.94 | 0 | 6 | 6 | 61 | 10.17 | 2 | 0 | 32 |
| 12 | Freeman, Royce, DAL | 13 | 77 | 5.92 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 13 |
| 12 | Evans, Zach, LAR | 3 | 6 | 2.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 13 | Harris, Najee, PIT | 16 | 63 | 3.94 | 0 | 3 | 2 | 14 | 7.00 | 0 | 0 | 7 |
| 13 | Warren, Jaylen, PIT | 9 | 59 | 6.56 | 0 | 3 | 1 | -4 | -4.00 | 0 | 0 | 5 |
| 15 | McCaffrey, Christian, SF | 18 | 115 | 6.39 | 1 | 5 | 5 | 72 | 14.40 | 2 | 0 | 36 |
| 15 | Juszczyk, Kyle, SF | 0 | 0 | 0 | 0 | 2 | 2 | 26 | 13.00 | 0 | 0 | 2 |
| 15 | Mason, Jordan, SF | 5 | 20 | 4.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 16 | Herbert, Khalil, CHI | 20 | 112 | 5.60 | 1 | 2 | 1 | 9 | 9.00 | 0 | 0 | 17 |
| 16 | Johnson, Roschon, CHI | 9 | 37 | 4.11 | 0 | 3 | 3 | 16 | 5.33 | 0 | 0 | 4 |
| 17 | Swift, D'Andre, CHI | 13 | 61 | 4.69 | 0 | 1 | 1 | 5 | 5.00 | 0 | 0 | 6 |
| 17 | Gainwell, Kenneth, PHI | 2 | 5 | 2.50 | 0 | 4 | 4 | 15 | 3.75 | 0 | 0 | 1 |
| 18 | Walker III, Kenneth, SEA | 17 | 78 | 4.59 | 0 | 1 | 1 | 3 | 3.00 | 0 | 0 | 7 |
| 18 | Charbonnet, Zach, SEA | 5 | 32 | 6.40 | 0 | 2 | 2 | 28 | 14.00 | 0 | 0 | 5 |