| All Running Backs vs Bills | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Montgomery, David, HOU | 20 | 60 | 3.00 | 2 | 3 | 3 | 19 | 6.33 | 1 | 0 | 25 |
| 1 | Marks, Woody, HOU | 9 | 42 | 4.67 | 0 | 1 | 1 | -2 | -2.00 | 0 | 0 | 4 |
| 2 | Gibbs, Jahmyr, DET | 16 | 52 | 3.25 | 0 | 8 | 6 | 61 | 10.17 | 1 | 0 | 17 |
| 2 | Vaki, Sione, DET | 1 | 7 | 7.00 | 0 | 1 | 1 | 13 | 13.00 | 0 | 0 | 1 |
| 3 | Mitchell, Keaton, LAC | 8 | 52 | 6.50 | 0 | 3 | 3 | -5 | -1.67 | 1 | 0 | 11 |
| 3 | Hampton, Omarion, LAC | 15 | 56 | 3.73 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5 |
| 3 | Ingold, Alec, LAC | 0 | 0 | 0 | 0 | 4 | 3 | 35 | 11.67 | 0 | 0 | 3 |
| 3 | Vidal, Kimani, LAC | 1 | 6 | 6.00 | 0 | 3 | 1 | 14 | 14.00 | 0 | 0 | 1 |
| 4 | Stevenson, Rhamondre, NE | 13 | 47 | 3.62 | 1 | 5 | 3 | 27 | 9.00 | 0 | 0 | 14 |
| 4 | Henderson, TreVeyon, NE | 14 | 42 | 3.00 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4 |
| 5 | Corum, Blake, LAR | 5 | 19 | 3.80 | 1 | 4 | 3 | 53 | 17.67 | 0 | 0 | 12 |
| 5 | Williams, Kyren, LAR | 16 | 49 | 3.06 | 1 | 8 | 6 | 27 | 4.50 | 0 | 0 | 12 |
| 6 | Jeanty, Ashton, LV | 10 | 22 | 2.20 | 1 | 6 | 4 | 36 | 9.00 | 0 | 0 | 11 |
| 6 | Washington Jr., Mike, LV | 9 | 43 | 4.78 | 0 | 1 | 1 | 7 | 7.00 | 0 | 0 | 4 |
| 6 | Laube, Dylan, LV | 1 | 0 | 0.00 | 0 | 1 | 1 | -1 | -1.00 | 0 | 0 | 0 |
| 8 | Henry, Derrick, BAL | 11 | 53 | 4.82 | 1 | 2 | 2 | 7 | 3.50 | 0 | 0 | 11 |
| 8 | Hill, Justice, BAL | 3 | 15 | 5.00 | 0 | 8 | 4 | 20 | 5.00 | 0 | 0 | 3 |
| 8 | Ali, Rasheen, BAL | 2 | 5 | 2.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 9 | Mason, Jordan, MIN | 6 | 35 | 5.83 | 0 | 3 | 2 | 7 | 3.50 | 0 | 0 | 3 |
| 9 | Jones, Aaron, MIN | 5 | 16 | 3.20 | 0 | 1 | 1 | 5 | 5.00 | 0 | 0 | 1 |
| 9 | Dallas, DeeJay, JAC | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 2.00 | 0 | 0 | 0 |