| All Running Backs vs Bills | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Henry, Derrick, BAL | 18 | 169 | 9.39 | 2 | 1 | 1 | 13 | 13.00 | 0 | 1 | 27 |
| 1 | Hill, Justice, BAL | 2 | -14 | -7.00 | 0 | 2 | 1 | 3 | 3.00 | 0 | 0 | 0 |
| 1 | Ali, Rasheen, BAL | 1 | 5 | 5.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2 | Hall, Breece, NYJ | 10 | 29 | 2.90 | 0 | 3 | 2 | 9 | 4.50 | 0 | 0 | 2 |
| 2 | Allen, Braelon, NYJ | 2 | 11 | 5.50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
| 2 | Davis, Isaiah, NYJ | 0 | 0 | 0 | 0 | 3 | 1 | 6 | 6.00 | 0 | 0 | 0 |
| 3 | Gordon II, Ollie, MIA | 9 | 38 | 4.22 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 9 |
| 3 | Achane, De'Von, MIA | 12 | 62 | 5.17 | 0 | 9 | 7 | 29 | 4.14 | 0 | 0 | 8 |
| 4 | Miller, Kendre, NO | 11 | 65 | 5.91 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 12 |
| 4 | Kamara, Alvin, NO | 15 | 70 | 4.67 | 0 | 5 | 4 | 2 | 0.50 | 0 | 0 | 7 |
| 5 | Stevenson, Rhamondre, NE | 7 | 14 | 2.00 | 2 | 2 | 2 | 13 | 6.50 | 0 | 1 | 12 |
| 5 | Henderson, TreVeyon, NE | 6 | 24 | 4.00 | 0 | 3 | 2 | 3 | 1.50 | 0 | 0 | 2 |
| 5 | Gibson, Antonio, NE | 6 | 21 | 3.50 | 0 | 1 | 1 | 5 | 5.00 | 0 | 0 | 2 |
| 6 | Robinson, Bijan, ATL | 19 | 170 | 8.95 | 1 | 8 | 6 | 68 | 11.33 | 0 | 0 | 29 |
| 6 | Allgeier, Tyler, ATL | 10 | 32 | 3.20 | 1 | 1 | 1 | 6 | 6.00 | 0 | 0 | 9 |
| 8 | Hubbard, Chuba, CAR | 12 | 34 | 2.83 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 9 |
| 8 | Dowdle, Rico, CAR | 8 | 54 | 6.75 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
| 8 | Etienne, Trevor, CAR | 4 | 16 | 4.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 9 | Hunt, Kareem, KC | 11 | 49 | 4.45 | 1 | 2 | 1 | 6 | 6.00 | 0 | 0 | 10 |
| 9 | Smith, Brashard, KC | 3 | 7 | 2.33 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 9 | Edwards-Helaire, Clyde, KC | 2 | 5 | 2.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 10 | Achane, De'Von, MIA | 22 | 174 | 7.91 | 2 | 6 | 6 | 51 | 8.50 | 0 | 0 | 34 |
| 10 | Wright, Jaylen, MIA | 5 | 17 | 3.40 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 10 | Ingold, Alec, MIA | 1 | 6 | 6.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 10 | Gordon II, Ollie, MIA | 1 | -3 | -3.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 11 | Tucker, Sean, TB | 19 | 106 | 5.58 | 2 | 2 | 2 | 34 | 17.00 | 1 | 0 | 31 |
| 11 | White, Rachaad, TB | 10 | 51 | 5.10 | 0 | 3 | 2 | 11 | 5.50 | 0 | 0 | 6 |
| 12 | Marks, Woody, HOU | 16 | 74 | 4.62 | 0 | 1 | 1 | -5 | -5.00 | 0 | 0 | 7 |
| 12 | Chubb, Nick, HOU | 6 | 16 | 2.67 | 0 | 1 | 1 | -1 | -1.00 | 0 | 0 | 1 |
| 13 | Warren, Jaylen, PIT | 10 | 35 | 3.50 | 1 | 4 | 2 | 9 | 4.50 | 0 | 0 | 9 |
| 13 | Gainwell, Kenneth, PIT | 5 | 20 | 4.00 | 0 | 3 | 2 | 25 | 12.50 | 0 | 0 | 4 |
| 13 | Johnson, Kaleb, PIT | 2 | 3 | 1.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |