| All Running Backs vs Broncos | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Walker III, Kenneth, KC | 23 | 173 | 7.52 | 1 | 6 | 3 | 18 | 6.00 | 1 | 0 | 30 |
| 1 | Johnson, Emmett, KC | 8 | 24 | 3.00 | 0 | 2 | 2 | 44 | 22.00 | 0 | 0 | 6 |
| 2 | Tuten, Bhayshul, JAC | 13 | 65 | 5.00 | 1 | 2 | 2 | -3 | -1.50 | 0 | 0 | 12 |
| 2 | Rodriguez Jr., Chris, JAC | 6 | 13 | 2.17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 2 | Abdullah, Ameer, JAC | 3 | 11 | 3.67 | 0 | 1 | 1 | 2 | 2.00 | 0 | 0 | 1 |
| 3 | Williams, Kyren, LAR | 15 | 88 | 5.87 | 0 | 7 | 6 | 70 | 11.67 | 0 | 0 | 15 |
| 3 | Corum, Blake, LAR | 6 | 15 | 2.50 | 0 | 4 | 2 | 0 | 0.00 | 0 | 0 | 1 |
| 4 | McCaffrey, Christian, SF | 15 | 52 | 3.47 | 1 | 5 | 3 | 18 | 6.00 | 0 | 0 | 12 |
| 4 | Juszczyk, Kyle, SF | 0 | 0 | 0 | 0 | 2 | 2 | 28 | 14.00 | 0 | 0 | 2 |
| 4 | Black, Kaelon, SF | 6 | 13 | 2.17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 5 | Vidal, Kimani, LAC | 8 | 57 | 7.12 | 1 | 2 | 1 | -1 | -1.00 | 0 | 0 | 11 |
| 5 | Hampton, Omarion, LAC | 14 | 33 | 2.36 | 0 | 1 | 1 | 6 | 6.00 | 0 | 0 | 3 |
| 5 | Mitchell, Keaton, LAC | 6 | 11 | 1.83 | 0 | 4 | 3 | 18 | 6.00 | 0 | 0 | 2 |
| 6 | Holani, George, SEA | 5 | 20 | 4.00 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 8 |
| 6 | Wilson, Emanuel, SEA | 14 | 52 | 3.71 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5 |
| 6 | Jones Jr., Velus, SEA | 4 | 20 | 5.00 | 0 | 1 | 1 | -1 | -1.00 | 0 | 0 | 2 |