| All Running Backs vs Lions | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Pacheco, Isiah, KC | 8 | 23 | 2.88 | 0 | 4 | 4 | 31 | 7.75 | 0 | 0 | 5 |
| 1 | Edwards-Helaire, Clyde, KC | 6 | 22 | 3.67 | 0 | 1 | 1 | 7 | 7.00 | 0 | 0 | 2 |
| 1 | McKinnon, Jerick, KC | 0 | 0 | 0 | 0 | 2 | 1 | 10 | 10.00 | 0 | 0 | 1 |
| 2 | Walker III, Kenneth, SEA | 17 | 43 | 2.53 | 2 | 2 | 1 | 11 | 11.00 | 0 | 0 | 17 |
| 2 | Charbonnet, Zach, SEA | 4 | 16 | 4.00 | 0 | 2 | 2 | 14 | 7.00 | 0 | 0 | 2 |
| 2 | Dallas, DeeJay, ARI | 1 | 3 | 3.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3 | Robinson, Bijan, ATL | 10 | 33 | 3.30 | 0 | 6 | 4 | 27 | 6.75 | 0 | 0 | 5 |
| 3 | Allgeier, Tyler, ATL | 7 | 12 | 1.71 | 0 | 3 | 2 | 17 | 8.50 | 0 | 0 | 2 |
| 4 | Dillon, A.J., GB | 5 | 11 | 2.20 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
| 4 | Jones, Aaron, MIN | 5 | 18 | 3.60 | 0 | 2 | 1 | -4 | -4.00 | 0 | 0 | 1 |
| 5 | Hubbard, Chuba, CAR | 9 | 35 | 3.89 | 0 | 2 | 1 | 0 | 0.00 | 0 | 0 | 3 |
| 5 | Sanders, Miles, CAR | 7 | 32 | 4.57 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
| 6 | White, Rachaad, TB | 7 | 26 | 3.71 | 0 | 4 | 3 | 12 | 4.00 | 0 | 0 | 3 |
| 6 | Vaughn, Ke'Shawn, NE | 6 | 9 | 1.50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| 7 | Edwards, Gus, LAC | 14 | 64 | 4.57 | 1 | 1 | 1 | 80 | 80.00 | 0 | 0 | 20 |
| 7 | Hill, Justice, BAL | 4 | 46 | 11.50 | 0 | 1 | 1 | 2 | 2.00 | 0 | 0 | 4 |
| 7 | Ricard, Patrick, BAL | 0 | 0 | 0 | 0 | 2 | 2 | 31 | 15.50 | 0 | 0 | 3 |
| 7 | Mitchell, Keaton, BAL | 0 | 0 | 0 | 0 | 1 | 1 | 9 | 9.00 | 0 | 0 | 0 |
| 8 | Jacobs, Josh, GB | 15 | 61 | 4.07 | 1 | 4 | 2 | 27 | 13.50 | 0 | 0 | 14 |
| 8 | Abdullah, Ameer, LV | 1 | 7 | 7.00 | 0 | 1 | 1 | 12 | 12.00 | 0 | 0 | 1 |
| 10 | Ekeler, Austin, WAS | 19 | 67 | 3.53 | 1 | 7 | 4 | 48 | 12.00 | 0 | 0 | 16 |
| 10 | Kelley, Joshua, LAC | 5 | 16 | 3.20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 11 | Foreman, D'Onta, CLE | 6 | 14 | 2.33 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 7 |
| 11 | Johnson, Roschon, CHI | 6 | 30 | 5.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
| 11 | Herbert, Khalil, CHI | 16 | 35 | 2.19 | 0 | 3 | 2 | 6 | 3.00 | 0 | 0 | 3 |
| 12 | Dillon, A.J., GB | 14 | 43 | 3.07 | 0 | 3 | 3 | 38 | 12.67 | 0 | 0 | 7 |
| 12 | Taylor, Patrick, SF | 3 | 11 | 3.67 | 0 | 1 | 1 | 4 | 4.00 | 0 | 0 | 1 |
| 13 | Kamara, Alvin, NO | 14 | 51 | 3.64 | 2 | 8 | 6 | 58 | 9.67 | 0 | 0 | 22 |
| 13 | Williams, Jamaal, NO | 5 | 10 | 2.00 | 0 | 1 | 1 | 6 | 6.00 | 0 | 0 | 1 |
| 14 | Foreman, D'Onta, CLE | 11 | 50 | 4.55 | 0 | 3 | 2 | 22 | 11.00 | 0 | 0 | 7 |
| 14 | Johnson, Roschon, CHI | 1 | 6 | 6.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 14 | Herbert, Khalil, CHI | 3 | 8 | 2.67 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 14 | Blasingame, Khari, CHI | 0 | 0 | 0 | 0 | 1 | 1 | -3 | -3.00 | 0 | 0 | 0 |
| 15 | Perine, Samaje, DEN | 6 | 37 | 6.17 | 0 | 1 | 1 | 11 | 11.00 | 0 | 0 | 4 |
| 15 | Williams, Javonte, DEN | 12 | 27 | 2.25 | 0 | 2 | 2 | -7 | -3.50 | 0 | 0 | 2 |
| 15 | McLaughlin, Jaleel, DEN | 2 | 2 | 1.00 | 0 | 3 | 2 | 16 | 8.00 | 0 | 0 | 1 |
| 16 | Chandler, Ty, MIN | 8 | 17 | 2.12 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 7 |
| 16 | Ham, C.J., MIN | 0 | 0 | 0 | 0 | 1 | 1 | 6 | 6.00 | 0 | 0 | 0 |
| 16 | Mattison, Alexander, LV | 2 | -1 | -0.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 17 | Pollard, Tony, TEN | 16 | 49 | 3.06 | 0 | 3 | 1 | 0 | 0.00 | 0 | 0 | 4 |
| 17 | Vaughn, Deuce, DAL | 2 | 2 | 1.00 | 0 | 1 | 1 | 10 | 10.00 | 0 | 0 | 1 |
| 18 | Chandler, Ty, MIN | 12 | 69 | 5.75 | 0 | 3 | 2 | 20 | 10.00 | 0 | 0 | 8 |
| 18 | Mattison, Alexander, LV | 7 | 24 | 3.43 | 0 | 1 | 1 | 5 | 5.00 | 0 | 0 | 2 |
| 19 | Williams, Kyren, LAR | 13 | 61 | 4.69 | 0 | 1 | 1 | 9 | 9.00 | 0 | 0 | 6 |
| 19 | Rivers, Ronnie, LAR | 3 | 9 | 3.00 | 0 | 3 | 3 | 35 | 11.67 | 0 | 0 | 3 |
| 20 | White, Rachaad, TB | 9 | 55 | 6.11 | 0 | 5 | 4 | 36 | 9.00 | 1 | 0 | 14 |
| 20 | Edmonds, Chase, TB | 4 | 19 | 4.75 | 0 | 2 | 2 | 18 | 9.00 | 0 | 0 | 2 |
| 21 | McCaffrey, Christian, SF | 20 | 90 | 4.50 | 2 | 5 | 4 | 42 | 10.50 | 0 | 0 | 25 |
| 21 | Mitchell, Elijah, SF | 4 | 7 | 1.75 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 21 | Juszczyk, Kyle, SF | 1 | 3 | 3.00 | 0 | 3 | 2 | 33 | 16.50 | 0 | 0 | 3 |