| All Running Backs vs Texans | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Taylor, Jonathan, IND | 16 | 48 | 3.00 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 10 |
| 2 | Herbert, Khalil, IND | 2 | 3 | 1.50 | 1 | 2 | 2 | 4 | 2.00 | 0 | 0 | 6 |
| 2 | Swift, D'Andre, CHI | 14 | 18 | 1.29 | 0 | 5 | 4 | 24 | 6.00 | 0 | 0 | 3 |
| 2 | Homer, Travis, CHI | 1 | 6 | 6.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3 | Jones, Aaron, MIN | 19 | 102 | 5.37 | 0 | 6 | 5 | 46 | 9.20 | 1 | 0 | 20 |
| 3 | Chandler, Ty, MIN | 7 | 13 | 1.86 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 4 | Bigsby, Tank, JAC | 7 | 90 | 12.86 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9 |
| 4 | Etienne, Travis, JAC | 11 | 50 | 4.55 | 0 | 2 | 1 | 10 | 10.00 | 0 | 0 | 6 |
| 4 | Johnson, D'Ernest, JAC | 2 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 5 | Cook, James, BUF | 20 | 82 | 4.10 | 1 | 3 | 2 | 17 | 8.50 | 0 | 0 | 15 |
| 5 | Johnson, Ty, BUF | 3 | 15 | 5.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 5 | Davis, Ray, BUF | 0 | 0 | 0 | 0 | 2 | 1 | 4 | 4.00 | 0 | 0 | 0 |
| 6 | Gibson, Antonio, NE | 13 | 19 | 1.46 | 0 | 4 | 3 | 24 | 8.00 | 0 | 0 | 3 |
| 6 | Jennings, Terrell, NE | 5 | 13 | 2.60 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 6 | Hasty, JaMycal, NE | 3 | 12 | 4.00 | 0 | 2 | 1 | 9 | 9.00 | 0 | 0 | 1 |
| 7 | Jacobs, Josh, GB | 12 | 76 | 6.33 | 0 | 5 | 5 | 16 | 3.20 | 1 | 0 | 14 |
| 7 | Wilson, Emanuel, GB | 5 | 11 | 2.20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 8 | Taylor, Jonathan, IND | 20 | 105 | 5.25 | 1 | 1 | 1 | 12 | 12.00 | 0 | 0 | 17 |
| 8 | Sermon, Trey, IND | 0 | 0 | 0 | 0 | 1 | 1 | 14 | 14.00 | 0 | 0 | 1 |
| 9 | Hall, Breece, NYJ | 15 | 74 | 4.93 | 0 | 4 | 2 | 11 | 5.50 | 0 | 0 | 8 |
| 9 | Allen, Braelon, NYJ | 4 | 9 | 2.25 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 10 | Montgomery, David, DET | 12 | 32 | 2.67 | 1 | 2 | 1 | 24 | 24.00 | 0 | 0 | 11 |
| 10 | Gibbs, Jahmyr, DET | 19 | 71 | 3.74 | 0 | 3 | 2 | 37 | 18.50 | 0 | 0 | 10 |
| 11 | Dowdle, Rico, CAR | 10 | 28 | 2.80 | 0 | 5 | 2 | 6 | 3.00 | 0 | 0 | 2 |
| 11 | Vaughn, Deuce, DAL | 4 | 13 | 3.25 | 0 | 2 | 1 | 4 | 4.00 | 0 | 0 | 1 |
| 11 | Elliott, Ezekiel, LAC | 1 | 8 | 8.00 | 0 | 3 | 3 | 16 | 5.33 | 0 | 0 | 1 |
| 12 | Pollard, Tony, TEN | 24 | 119 | 4.96 | 1 | 5 | 3 | 10 | 3.33 | 0 | 0 | 18 |
| 12 | Chestnut, Julius, TEN | 1 | 3 | 3.00 | 0 | 1 | 1 | 2 | 2.00 | 0 | 0 | 0 |
| 13 | Etienne, Travis, JAC | 13 | 46 | 3.54 | 0 | 3 | 3 | 12 | 4.00 | 0 | 0 | 5 |
| 13 | Bigsby, Tank, JAC | 7 | 28 | 4.00 | 0 | 1 | 1 | 7 | 7.00 | 0 | 0 | 2 |
| 15 | Achane, De'Von, MIA | 12 | 41 | 3.42 | 0 | 7 | 7 | 35 | 5.00 | 0 | 0 | 7 |
| 15 | Mostert, Raheem, LV | 6 | 8 | 1.33 | 0 | 3 | 3 | 13 | 4.33 | 0 | 0 | 1 |
| 15 | Wright, Jaylen, MIA | 1 | 3 | 3.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 16 | Hunt, Kareem, KC | 11 | 55 | 5.00 | 1 | 3 | 2 | 24 | 12.00 | 0 | 0 | 13 |
| 16 | Perine, Samaje, CIN | 0 | 0 | 0 | 0 | 3 | 3 | 50 | 16.67 | 0 | 0 | 5 |
| 16 | Pacheco, Isiah, KC | 9 | 26 | 2.89 | 0 | 2 | 1 | -1 | -1.00 | 0 | 0 | 2 |
| 17 | Henry, Derrick, BAL | 27 | 147 | 5.44 | 1 | 2 | 2 | 18 | 9.00 | 0 | 0 | 21 |
| 17 | Mitchell, Keaton, BAL | 11 | 20 | 1.82 | 0 | 1 | 1 | 28 | 28.00 | 0 | 0 | 4 |
| 17 | Ali, Rasheen, BAL | 1 | -3 | -3.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | Pollard, Tony, TEN | 22 | 62 | 2.82 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 |
| 18 | Chestnut, Julius, TEN | 2 | 11 | 5.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 18 | Kelley, Joshua, TEN | 1 | 2 | 2.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 19 | Edwards, Gus, LAC | 7 | 22 | 3.14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 19 | Dobbins, J.K., LAC | 9 | 26 | 2.89 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 |
| 19 | Haskins, Hassan, LAC | 1 | 5 | 5.00 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 20 | Hunt, Kareem, KC | 8 | 44 | 5.50 | 1 | 1 | 1 | 2 | 2.00 | 0 | 0 | 10 |
| 20 | Pacheco, Isiah, KC | 5 | 18 | 3.60 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |