| All Running Backs vs Texans | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Cook, James, BUF | 13 | 57 | 4.38 | 0 | 4 | 3 | 12 | 4.00 | 0 | 0 | 6 |
| 1 | Davis, Ray, BUF | 1 | 3 | 3.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 1 | Gore Jr., Frank, BUF | 1 | 3 | 3.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2 | Brown, Chase, CIN | 20 | 80 | 4.00 | 0 | 5 | 3 | 2 | 0.67 | 0 | 0 | 8 |
| 2 | Perine, Samaje, CIN | 2 | 6 | 3.00 | 0 | 1 | 1 | 16 | 16.00 | 0 | 0 | 1 |
| 3 | Taylor, Jonathan, IND | 23 | 68 | 2.96 | 0 | 3 | 2 | 4 | 2.00 | 0 | 0 | 6 |
| 3 | McGowan, Seth, IND | 4 | 14 | 3.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 4 | Williams, Javonte, DAL | 19 | 62 | 3.26 | 3 | 5 | 5 | 21 | 4.20 | 0 | 0 | 26 |
| 4 | Goodson, Tyler, ATL | 3 | 12 | 4.00 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
| 4 | Luepke, Hunter, DAL | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 2.00 | 0 | 0 | 0 |
| 5 | Pollard, Tony, TEN | 14 | 52 | 3.71 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5 |
| 5 | Mullings, Kalel, TEN | 1 | 3 | 3.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 5 | Spears, Tyjae, TEN | 2 | 0 | 0.00 | 0 | 9 | 9 | 28 | 3.11 | 0 | 1 | 0 |