| All Running Backs vs Jaguars | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Hubbard, Chuba, CAR | 16 | 57 | 3.56 | 0 | 5 | 3 | 32 | 10.67 | 1 | 0 | 14 |
| 1 | Dowdle, Rico, CAR | 3 | 12 | 4.00 | 0 | 3 | 2 | 4 | 2.00 | 0 | 0 | 1 |
| 1 | Etienne, Trevor, CAR | 1 | 4 | 4.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2 | Brown, Chase, CIN | 16 | 47 | 2.94 | 0 | 3 | 2 | 18 | 9.00 | 0 | 0 | 5 |
| 3 | Chubb, Nick, HOU | 9 | 38 | 4.22 | 0 | 4 | 3 | 2 | 0.67 | 0 | 0 | 3 |
| 3 | Marks, Woody, HOU | 6 | 27 | 4.50 | 0 | 2 | 1 | 9 | 9.00 | 0 | 0 | 2 |
| 4 | McCaffrey, Christian, SF | 17 | 49 | 2.88 | 0 | 11 | 6 | 92 | 15.33 | 1 | 0 | 19 |
| 4 | Juszczyk, Kyle, SF | 0 | 0 | 0 | 0 | 3 | 3 | 32 | 10.67 | 0 | 0 | 3 |
| 4 | Robinson Jr., Brian, SF | 5 | 21 | 4.20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 5 | Hunt, Kareem, KC | 7 | 49 | 7.00 | 2 | 1 | 1 | 8 | 8.00 | 0 | 0 | 16 |
| 5 | Pacheco, Isiah, KC | 7 | 36 | 5.14 | 0 | 3 | 3 | 20 | 6.67 | 0 | 0 | 5 |
| 5 | Smith, Brashard, KC | 1 | 4 | 4.00 | 0 | 3 | 3 | 32 | 10.67 | 0 | 0 | 3 |
| 6 | Walker III, Kenneth, SEA | 10 | 34 | 3.40 | 0 | 1 | 1 | 3 | 3.00 | 0 | 0 | 3 |
| 6 | Charbonnet, Zach, SEA | 12 | 24 | 2.00 | 0 | 1 | 1 | 13 | 13.00 | 0 | 0 | 3 |
| 7 | Williams, Kyren, LAR | 12 | 54 | 4.50 | 0 | 3 | 2 | 11 | 5.50 | 0 | 0 | 6 |
| 7 | Corum, Blake, LAR | 12 | 37 | 3.08 | 0 | 1 | 1 | 6 | 6.00 | 0 | 0 | 3 |
| 9 | Jeanty, Ashton, LV | 13 | 42 | 3.23 | 0 | 5 | 5 | 47 | 9.40 | 1 | 0 | 14 |
| 9 | Mostert, Raheem, LV | 0 | 0 | 0 | 0 | 1 | 1 | 14 | 14.00 | 0 | 0 | 1 |
| 10 | Marks, Woody, HOU | 14 | 63 | 4.50 | 1 | 3 | 2 | 18 | 9.00 | 0 | 0 | 13 |
| 10 | Chubb, Nick, HOU | 5 | 47 | 9.40 | 0 | 1 | 1 | 5 | 5.00 | 0 | 0 | 4 |
| 11 | Vidal, Kimani, LAC | 5 | 13 | 2.60 | 0 | 2 | 2 | -1 | -0.50 | 0 | 0 | 1 |
| 11 | Williams, Trayveon, LAC | 3 | -1 | -0.33 | 0 | 1 | 1 | 0 | 0.00 | 0 | 0 | 0 |
| 11 | Johnson, Amar, LAC | 2 | 8 | 4.00 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 12 | Knight, Zonovan, ARI | 10 | 12 | 1.20 | 1 | 5 | 4 | 20 | 5.00 | 0 | 0 | 9 |
| 12 | Carter, Michael, ARI | 5 | 28 | 5.60 | 0 | 3 | 3 | 30 | 10.00 | 0 | 0 | 5 |
| 13 | Pollard, Tony, TEN | 10 | 60 | 6.00 | 0 | 2 | 1 | 3 | 3.00 | 0 | 1 | 4 |
| 13 | Spears, Tyjae, TEN | 2 | -1 | -0.50 | 0 | 6 | 6 | 25 | 4.17 | 0 | 0 | 2 |
| 14 | Taylor, Jonathan, IND | 21 | 74 | 3.52 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 11 |
| 14 | Abdullah, Ameer, IND | 1 | 4 | 4.00 | 0 | 2 | 2 | 5 | 2.50 | 0 | 0 | 0 |