| All Running Backs vs Chargers | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Love, Jeremiyah, ARI | 11 | 41 | 3.73 | 1 | 4 | 2 | 9 | 4.50 | 0 | 0 | 10 |
| 1 | Allgeier, Tyler, ARI | 17 | 61 | 3.59 | 0 | 2 | 2 | 9 | 4.50 | 0 | 0 | 6 |
| 2 | Jeanty, Ashton, LV | 21 | 48 | 2.29 | 0 | 7 | 4 | 15 | 3.75 | 0 | 0 | 5 |
| 2 | Washington Jr., Mike, LV | 3 | 7 | 2.33 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3 | Cook, James, BUF | 24 | 154 | 6.42 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 19 |
| 3 | Johnson, Ty, BUF | 0 | 0 | 0 | 0 | 4 | 4 | 50 | 12.50 | 0 | 0 | 5 |
| 4 | Wilson, Emanuel, SEA | 21 | 81 | 3.86 | 1 | 4 | 3 | 39 | 13.00 | 1 | 0 | 23 |
| 4 | Holani, George, SEA | 7 | 18 | 2.57 | 0 | 1 | 1 | 2 | 2.00 | 0 | 0 | 1 |
| 5 | Dobbins, J.K., DEN | 18 | 68 | 3.78 | 1 | 2 | 2 | 6 | 3.00 | 0 | 0 | 12 |
| 5 | Harvey, RJ, DEN | 3 | 7 | 2.33 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 5 | Badie, Tyler, DEN | 1 | 6 | 6.00 | 0 | 1 | 1 | -5 | -5.00 | 0 | 0 | 0 |
| 5 | Prentice, Adam, DEN | 1 | 3 | 3.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 6 | Walker III, Kenneth, KC | 19 | 128 | 6.74 | 2 | 3 | 2 | 11 | 5.50 | 0 | 0 | 25 |
| 6 | Johnson, Emmett, KC | 3 | 6 | 2.00 | 0 | 3 | 2 | 18 | 9.00 | 0 | 0 | 1 |
| 8 | Corum, Blake, LAR | 11 | 73 | 6.64 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 13 |
| 8 | Williams, Kyren, LAR | 16 | 56 | 3.50 | 1 | 1 | 1 | 3 | 3.00 | 0 | 0 | 11 |
| 9 | Marks, Woody, HOU | 18 | 70 | 3.89 | 0 | 4 | 1 | 4 | 4.00 | 0 | 0 | 7 |
| 9 | Demercado, Emari, KC | 6 | 16 | 2.67 | 0 | 2 | 1 | 8 | 8.00 | 0 | 0 | 1 |
| 9 | Ogunbowale, Dare, LV | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 3.00 | 0 | 0 | 0 |