| All Running Backs vs Rams | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | McCaffrey, Christian, SF | 10 | 68 | 6.80 | 0 | 8 | 5 | 20 | 4.00 | 0 | 0 | 8 |
| 1 | Black, Kaelon, SF | 14 | 65 | 4.64 | 0 | 1 | 1 | 5 | 5.00 | 0 | 0 | 6 |
| 2 | Skattebo, Cam, NYG | 12 | 36 | 3.00 | 0 | 4 | 4 | 19 | 4.75 | 0 | 0 | 4 |
| 2 | Singletary, Devin, NYG | 3 | 9 | 3.00 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2 | Harris, Najee, NYG | 4 | 6 | 1.50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3 | Dobbins, J.K., DEN | 17 | 49 | 2.88 | 0 | 2 | 1 | 4 | 4.00 | 0 | 0 | 4 |
| 3 | Harvey, RJ, DEN | 2 | 6 | 3.00 | 0 | 7 | 6 | 41 | 6.83 | 0 | 0 | 4 |
| 3 | Badie, Tyler, DEN | 1 | 2 | 2.00 | 0 | 1 | 1 | 12 | 12.00 | 0 | 0 | 1 |
| 4 | Bigsby, Tank, PHI | 14 | 55 | 3.93 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5 |
| 4 | Shipley, Will, PHI | 6 | 23 | 3.83 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 |
| 4 | Barkley, Saquon, PHI | 2 | 8 | 4.00 | 0 | 1 | 1 | 2 | 2.00 | 0 | 0 | 0 |
| 5 | Cook, James, BUF | 25 | 111 | 4.44 | 2 | 1 | 1 | 7 | 7.00 | 0 | 1 | 21 |
| 5 | Johnson, Ty, BUF | 0 | 0 | 0 | 0 | 4 | 4 | 72 | 18.00 | 0 | 0 | 7 |
| 5 | Davis, Ray, BUF | 2 | 2 | 1.00 | 0 | 1 | 1 | 31 | 31.00 | 0 | 0 | 3 |
| 6 | Knight, Zonovan, ARI | 15 | 80 | 5.33 | 0 | 2 | 2 | 18 | 9.00 | 0 | 0 | 9 |
| 6 | Allgeier, Tyler, ARI | 18 | 38 | 2.11 | 0 | 2 | 1 | 10 | 10.00 | 0 | 0 | 4 |
| 7 | Jeanty, Ashton, LV | 8 | 15 | 1.88 | 0 | 8 | 8 | 61 | 7.62 | 1 | 0 | 13 |
| 7 | Washington Jr., Mike, LV | 6 | 27 | 4.50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 |
| 8 | Vidal, Kimani, LAC | 8 | 23 | 2.88 | 0 | 2 | 2 | 7 | 3.50 | 0 | 0 | 2 |
| 8 | Hampton, Omarion, LAC | 9 | 20 | 2.22 | 0 | 3 | 2 | 7 | 3.50 | 0 | 0 | 2 |
| 8 | Mitchell, Keaton, LAC | 4 | 6 | 1.50 | 0 | 3 | 3 | 17 | 5.67 | 0 | 0 | 1 |
| 9 | White, Rachaad, WAS | 7 | 28 | 4.00 | 0 | 3 | 2 | 41 | 20.50 | 0 | 1 | 4 |
| 9 | Ekeler, Austin, WAS | 8 | 16 | 2.00 | 0 | 3 | 2 | 18 | 9.00 | 0 | 0 | 2 |