| All Running Backs vs Saints | ||||||||||||
| Rushing | Receiving | |||||||||||
| Week | Player | Att | Yd | Avg | TD | Targt | Recpt | Yd | Avg | TD | FL | FPTS |
| 1 | Conner, James, ARI | 12 | 39 | 3.25 | 0 | 4 | 4 | 5 | 1.25 | 1 | 0 | 9 |
| 1 | Benson, Trey, ARI | 8 | 69 | 8.62 | 0 | 1 | 1 | 6 | 6.00 | 0 | 0 | 6 |
| 2 | McCaffrey, Christian, SF | 13 | 55 | 4.23 | 0 | 7 | 6 | 52 | 8.67 | 1 | 0 | 16 |
| 2 | Robinson Jr., Brian, SF | 6 | 20 | 3.33 | 0 | 1 | 1 | -1 | -1.00 | 0 | 0 | 2 |
| 2 | Juszczyk, Kyle, SF | 0 | 0 | 0 | 0 | 1 | 1 | 5 | 5.00 | 0 | 0 | 0 |
| 3 | Walker III, Kenneth, SEA | 16 | 38 | 2.38 | 2 | 1 | 1 | 12 | 12.00 | 0 | 0 | 16 |
| 3 | Wright, Jacardia, SEA | 5 | 20 | 4.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| 3 | Holani, George, SEA | 10 | 27 | 2.70 | 0 | 2 | 2 | 15 | 7.50 | 0 | 1 | 1 |
| 4 | Cook, James, BUF | 22 | 117 | 5.32 | 1 | 4 | 3 | 18 | 6.00 | 0 | 0 | 18 |
| 4 | Davis, Ray, BUF | 1 | 3 | 3.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4 | Johnson, Ty, BUF | 1 | 0 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 5 | Skattebo, Cam, NYG | 15 | 59 | 3.93 | 0 | 7 | 6 | 45 | 7.50 | 0 | 1 | 7 |
| 5 | Singletary, Devin, NYG | 6 | 20 | 3.33 | 0 | 2 | 1 | 4 | 4.00 | 0 | 0 | 2 |
| 6 | Henderson, TreVeyon, NE | 9 | 27 | 3.00 | 0 | 2 | 1 | 9 | 9.00 | 0 | 0 | 2 |
| 6 | Stevenson, Rhamondre, NE | 13 | 18 | 1.38 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
| 7 | Swift, D'Andre, CHI | 19 | 124 | 6.53 | 1 | 1 | 1 | 14 | 14.00 | 0 | 0 | 19 |
| 7 | Monangai, Kyle, CHI | 13 | 81 | 6.23 | 1 | 3 | 2 | 13 | 6.50 | 0 | 0 | 15 |
| 7 | Johnson, Roschon, CHI | 1 | 11 | 11.00 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 8 | Tucker, Sean, TB | 12 | 42 | 3.50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 10 |
| 8 | White, Rachaad, TB | 13 | 35 | 2.69 | 0 | 2 | 2 | 26 | 13.00 | 0 | 0 | 5 |
| 8 | Williams, Josh, TB | 4 | 11 | 2.75 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 9 | Williams, Kyren, LAR | 25 | 114 | 4.56 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 17 |
| 9 | Corum, Blake, LAR | 13 | 58 | 4.46 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
| 10 | Dowdle, Rico, CAR | 18 | 53 | 2.94 | 1 | 3 | 3 | 10 | 3.33 | 0 | 0 | 12 |
| 10 | Hubbard, Chuba, CAR | 3 | 14 | 4.67 | 0 | 1 | 1 | 1 | 1.00 | 0 | 0 | 1 |
| 12 | Robinson, Bijan, ATL | 14 | 70 | 5.00 | 0 | 2 | 2 | 37 | 18.50 | 0 | 0 | 12 |
| 12 | Allgeier, Tyler, ATL | 12 | 44 | 3.67 | 0 | 1 | 1 | 5 | 5.00 | 0 | 0 | 4 |
| 13 | Achane, De'Von, MIA | 22 | 134 | 6.09 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 19 |
| 13 | Gordon II, Ollie, MIA | 3 | 10 | 3.33 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 13 | Wright, Jaylen, MIA | 3 | 16 | 5.33 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| 14 | Irving, Bucky, TB | 15 | 55 | 3.67 | 0 | 3 | 2 | 26 | 13.00 | 1 | 0 | 13 |
| 14 | Tucker, Sean, TB | 7 | 29 | 4.14 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 8 |
| 14 | White, Rachaad, TB | 11 | 53 | 4.82 | 0 | 2 | 1 | 2 | 2.00 | 0 | 0 | 5 |
| 15 | Dowdle, Rico, CAR | 16 | 49 | 3.06 | 1 | 1 | 1 | 5 | 5.00 | 0 | 0 | 10 |
| 15 | Hubbard, Chuba, CAR | 8 | 29 | 3.62 | 0 | 1 | 1 | 9 | 9.00 | 0 | 0 | 2 |
| 16 | Davis, Isaiah, NYJ | 3 | 8 | 2.67 | 0 | 4 | 4 | 52 | 13.00 | 0 | 0 | 5 |
| 16 | Hall, Breece, NYJ | 16 | 54 | 3.38 | 0 | 3 | 2 | 9 | 4.50 | 0 | 0 | 5 |