The Boston Celtics will try to stay hot when they take on the rival Philadelphia 76ers in an Atlantic Division matchup at the Wells Fargo Center on Friday in Philadelphia. The Celtics (21-21) have won three straight games by an average of 15.3 points per contest. The winning streak has propelled Boston into 10th place in the Eastern Conference. Meanwhile, the 76ers (23-17) have won seven of their last eight games but are coming off a 109-98 loss on Wednesday to Charlotte. 

Tipoff is set for 7 p.m. ET. Caesars Sportsbook lists Philadelphia as a 3.5-point favorite in the latest 76ers vs. Celtics odds, while the over-under, or total number of points expected, is 207.5. Before making any Celtics vs. 76ers picks, be sure to see the NBA predictions and betting advice from SportsLine's proven computer model

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model entered Week 13 of the 2021-22 NBA season on a stunning 52-28 roll on all top-rated NBA picks, returning almost $2,000. Anyone following it has seen huge returns.

Now, the model has set its sights on Sixers vs. Celtics, and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model's picks. Now, here are several NBA betting lines and trends for Celtics vs. Sixers:

  • 76ers vs. Celtics spread: Philadelphia -3.5
  • 76ers vs. Celtics over-under: 207.5 points
  • 76ers vs. Celtics money line: Philadelphia -160, Boston +140
  • PHI: Joel Embiid ranks fifth in the league in scoring, at 27.1 points per game.
  • BOS: The Celtics give up 106.9 points per 100 possessions, which ranks fifth in the NBA.
Featured Game | Philadelphia 76ers vs. Boston Celtics

Why the 76ers can cover

Joel Embiid has been a dominant force for Philadelphia. Over his last eight games, Embiid is averaging 32.6 points per game on 56.5 percent shooting from the field and 40.1 percent from the 3-point range. He has scored at least 30 points in eight straight games, joining Allen Iverson and Wilt Chamberlain as the only players in franchise history to do so.

In addition, the 76ers have been one of the most efficient offensive teams over the last three weeks. Beginning Dec. 26, Philadelphia is averaging 117.4 points per 100 possessions on offense, which ranks second in the NBA over that time. That's a significant improvement over the first two months of the season when the 76ers averaged 108.9 points per 100 possessions, which ranked 19th in the league.

Why the Celtics can cover

Boston is one of the best defensive teams in the league. The Celtics give up 106.9 points per 100 possessions, which ranks fifth in the NBA. They also allow opponents to shoot just 43.9 percent from the field, which is sixth in the league.

Two big reasons for Boston's success at the defensive end are Robert Williams III and Marcus Smart (questionable, thigh). Williams averages 2.2 blocks per game, which ranks third in the NBA. Meanwhile Smart averages 1.9 steals per game, which also is third in the league.

How to make Celtics vs. 76ers picks

SportsLine's model is leaning over on the total, projecting 215 combined points. The model also says one side of the spread hits well over 50 percent of the time. You can only see the model's pick at SportsLine.

So who wins Sixers vs. Celtics? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its NBA picks, and find out.