The San Francisco 49ers and Minnesota Vikings will face off in an inter-division NFC matchup on Monday Night Football. The 49ers (5-1) lost their first game of the season last Sunday, a 19-17 nailbiter in Cleveland, but still sit comfortably atop the NFC West standings. The Vikings (2-4) beat the Bears 19-13 last Sunday at Soldier Field. It was their second victory in their past three games, but they are third in the NFC North behind the 5-1 Lions and 2-3 Packers. Both teams went 13-4 last season and made the playoffs, but the Vikings have struggled against a tough early schedule. The 49ers will be without receiver Deebo Samuel (shoulder), while running back Christian McCaffrey (oblique) is active after entering the game as questionable.
Monday's kickoff in Minneapolis is set for 8:15 p.m. ET. The latest 49ers vs. Vikings odds list San Francisco as a seven-point favorite, and the over/under for total points scored is 43. Before you make any Vikings vs. 49ers picks, you need to see the NFL predictions and betting advice from SportsLine's advanced computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 7 of the 2023 NFL season on an incredible 172-120 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 26-12 roll on top-rated NFL picks since Week 7 of last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has simulated 49ers vs. Vikings 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Vikings vs. 49ers:
- 49ers vs. Vikings spread: San Francisco -7
- 49ers vs. Vikings Over/Under: 43 points
- 49ers vs. Vikings money line: San Francisco -304, Minnesota +238
- SF: 49ers are 9-10 against the spread as road favorites since 2020
- MIN: Vikings are 7-4 ATS in their past 11 games as home underdogs
- 49ers vs. Vikings picks: See picks at SportsLine
- 49ers vs. Vikings live stream: fubo (try for free)
Why the 49ers can cover
San Francisco will be able to dictate the game and make Kirk Cousins win it without star receiver Justin Jefferson. The Vikings average just 75 rushing yards per game (30th in NFL) and still don't have a rushing TD. The 49ers' defense is third overall (278 yards per game), fifth against the run (80 yards per game) and first in scoring (14.5 points per game). San Francisco is third in the NFL in QB knockdowns, and Nick Bosa, Arik Armstead and Javon Hargrave should make Cousins jumpy.
Linebacker Fred Warner leads a defense that has an NFL-high 10 interceptions, and he has two of those. Warner also has two sacks and a forced fumble. The Niners' offense snapped a run of eight straight games with 30 or more points, and it was quarterback Brock Purdy's first loss as a starter (10-1). He has 10 TD passes and one interception. Running back Christian McCaffrey, the NFL's top rusher with 553 yards, was injured last week but could be ready by Monday. See who to back at SportsLine.
Why the Vikings can cover
Minnesota will benefit greatly if some of the 49ers' stars can't play. Elite tackle Trent Williams, who has an ankle injury, is inactive and the Vikings have a formidable pass rush. Danielle Hunter is tied for the NFL lead with eight sacks. He had two last week, and the Vikings had three takeaways in the victory. With San Francisco's offense banged-up, the Vikings should keep another one close. They have played 17 one-score games since last season.
The Vikings went 11-0 in those close games on their way to the playoffs last season, but have lost four in 2023. Still, they have plenty of experience against top teams. The Vikings passing game is one of the league's best, averaging 264 yards (third). Kirk Cousins is second in the league with 1,679 passing yards and has 14 TD passes. Minnesota also has an edge at kicker, as Greg Joseph is 6-for-7 on field goals, while 49ers rookie Jake Moody missed two last week. See who to back at SportsLine.
How to make 49ers vs. Vikings picks
SportsLine's model is leaning Under the total, projecting 42 combined points. The model also says one side of the spread has all the value. You can only see the model's NFL picks and analysis at SportsLine.
So who wins Vikings vs. 49ers on Monday Night Football, and which side of the spread has all the value? Visit SportsLine now to see which side of the Vikings vs. 49ers spread to back, all from the model that has returned well over $7,000 on top-rated NFL picks, and find out.
