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The defending NFC champion Philadelphia Eagles will try to continue their home success against Minnesota when they host the Vikings on Thursday Night Football as Week 2 of the 2023 NFL season gets underway. Including the playoffs, Philadelphia (1-0) has won 10 of its last 13 home games against Minnesota (0-1), the most recent victory being a 24-7 triumph in Week 2 last year. The Eagles opened this season with a 25-20 win at New England, while the Vikings suffered a 20-17 loss to Tampa Bay at home. 

Kickoff from Lincoln Financial Field in Philadelphia is set for 8:15 p.m. ET. Philadelphia is a six-point favorite in the latest Eagles vs. Vikings odds, while the over/under for total points scored is 49. Before making any Vikings vs. Eagles picks, you need to see the NFL predictions and betting advice from SportsLine's advanced computer model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model entered the 2023 NFL season on an incredible 163-114 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-7 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Eagles vs. Vikings and just locked in its picks and Thursday Night Football predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Vikings vs. Eagles: 

  • Eagles vs. Vikings spread: Philadelphia -6
  • Eagles vs. Vikings over/under: 49 points 
  • Eagles vs. Vikings money line: Philadelphia -260, Minnesota +214
  • PHI: Eagles are 7-2 against the spread in their last nine home games against Minnesota 
  • MIN: Vikings are 3-7 ATS in their last 10 contests, including playoffs
  • Eagles vs. Vikings picks: See picks at SportsLine

Why the Eagles can cover

Philadelphia's home victories against Minnesota have been convincing of late, as the last seven were by 11 points or more. Jalen Hurts threw for 333 yards in last year's win and will be eager to attack the Vikings' secondary after registering only 170 against the Patriots in Week 1. The 25-year-old quarterback also will be looking to connect with tight end Dallas Goedert, who did not have a catch in the season-opener but hauled in five passes for a team-high 82 yards versus Minnesota in 2022.

Hurts also has the dynamic duo of A.J. Brown and DeVonta Smith at his disposal. They became the first pair of receivers to both eclipse the 1,000-yard plateau in the same season last year, with Brown recording 1,496 and Smith amassing 1,196. The 26-year-old Brown led the Eagles with 79 receiving yards against New England and the 24-year-old Smith hauled in Hurts' lone touchdown pass of the game. See which team to pick here.

Why the Vikings can cover

Kirk Cousins has won his last three games played on Thursdays, including a 33-26 triumph over New England on Thanksgiving last year. The 35-year-old came up with a strong effort in that contest, completing 30-of-37 pass attempts for 299 yards and three touchdowns. Cousins was one of only five quarterbacks in the league to eclipse the 300-yard mark in Week 1 after he amassed 344 while completing 75% of his passes against the Buccaneers.

Two of Cousins' 33 completions in the season-opener were for TDs, including one to Justin Jefferson. The 24-year-old wideout, who was the NFL Offensive Player of the Year in 2022 after registering a league-high 1,809 receiving yards, finished with 150 on nine catches last Sunday. Jefferson needs one more 150-yard performance to tie Hall-of-Famer Lance Alworth (10) for most over his first four seasons in the NFL. See which team to pick here.

How to make Eagles vs. Vikings picks on TNF

SportsLine's model is leaning Over the point total, calling for 53 combined points. The model also says one side of the spread cashes in 60% of simulations. You can only see the model's TNF picks at SportsLine.

So who wins Vikings vs. Eagles on Thursday Night Football, and which side of the spread cashes 60% of the time? Visit SportsLine now to see which side of the Vikings vs. Eagles spread you need to jump on, all from the model on a 163-114 roll on NFL picks, and find out.