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Red Bull Arena hosts a UEFA Champions League match on Tuesday in Leipzig, Germany. Real Madrid visit RB Leipzig in the first match of a two-leg Round of 16 tie with aggregate scoring. The matchup begins the knockout round on both sides, and RB Leipzig won the most recent battle between the clubs on Matchday 5 last year. RB Leipzig are also hosting only their third-ever game against a Spanish club.

Kickoff is scheduled for 3 p.m. ET. Real Madrid are the +125 favorite (risk $100 to win $125) in its latest RB Leipzig vs. Real Madrid odds. Leipzig are a +200 underdog, a draw is priced at +270, and the over/under for total goals scored is 2.5. Before making any Real Madrid vs. RB Leipzig picks or UEFA Champions League predictions, be sure to see what proven soccer insider Jon Eimer is saying.

Eimer is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, he has covered the English Premier League, Serie A, the FA Cup, and much more. In 2023 he was red-hot, going 248-234-12 for a profit of $2,593 for $100 bettors. That included an 86-59-5 record in the Premier League for a $3,463 profit.

Now, Eimer has broken down RB Leipzig vs. Real Madrid from every angle and just revealed his picks and Champions League predictions. You can head to SportsLine now to see Eimer's picks. Here are the betting lines and trends for Real Madrid vs. RB Leipzig:

  • RB Leipzig vs. Real Madrid money line: Real Madrid +125, RB Leipzig +200, Draw +270
  • RB Leipzig vs. Real Madrid spread: Real Madrid -0.5 (+130)
  • RB Leipzig vs. Real Madrid over/under: 2.5 goals
  • RB Leipzig vs. Real Madrid picks: See picks at SportsLine

Why you should back RB Leipzig 

RB Leipzig have reached the Champions League knockout round in four of the last five seasons, and the club has earned two German Cup titles, including the 2023 crown. In the last 19 games at home against European clubs, RB Leipzig have 11 wins and five draws, and the club's offense is performing well. Leipzig accrued 13 goals and 12 assists during group stage action, and the club has 46 goals in the last 21 domestic matches. 

Forward Lois Openda leads the way for Leipzig, posting 15 goals in 21 games in Bundesliga action. He has a goal in four straight matches and also has four goals in five Champions League games in 2023-24. On the other side, Real Madrid will be without Jude Bellingham in this match, as he suffered an ankle injury against Girona on Saturday. Bellingham is the top scorer for Real Madrid this season, producing 20 goals across competitions and 16 goals in La Liga matches. See which team to pick here.

Why you should back Real Madrid 

While Bellingham is out for this match, Real Madrid have Vinicius Junior to key a dynamic offensive attack. He scored a goal and generated two assists in Real Madrid's overwhelming 4-0 win over Girona in their last outing, and he has 12 goals and seven assists across all competitions this season. Real Madrid have 16 goals in Champions League action this season, third-most in the competition, and the club ranks in the top four in possession (58.5%) and passing accuracy (92.8%). Real Madrid also have 12 assists with only seven goals allowed in UCL play. 

History is also on Real Madrid's side, as the club has a 28-year streak of reaching the knockout round in the UEFA Champions League. That includes 20 group wins, and Real Madrid won the UCL title in 2021-22. This year, Real Madrid is one of only two undefeated clubs in the group stage, winning all six games, and they finished eight points ahead of Napoli. Across all competitions, Real Madrid have won 10 of the last 12 games, while Leipzig have only one victory in the last four matches. See which team to pick here.

How to make RB Leipzig vs. Real Madrid picks

Eimer has broken down Tuesday's match from every possible angle and is leaning Over on the goal total. He also has locked in three confident best bets, including one that pays plus-money, and is offering a full breakdown of this Champions League clash. He's sharing his UEFA Champions League picks and analysis only at SportsLine.

So who wins Real Madrid vs. RB Leipzig, and where does all the betting value lie? Visit SportsLine now to see which wagers in RB Leipzig vs. Real Madrid have all the value, all from the soccer expert who finished 2023 up more than $2,500, and find out.