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Real Madrid attempt to remain perfect in the competition and advance to the quarterfinals when they host RB Leipzig for the second leg of their Round of 16 tie in the UEFA Champions League on Wednesday. Real Madrid, who have won a record 14 UCL titles, were victorious in each of their six group-stage matches before defeating RB Leipzig 1-0 in the first leg. The Red Bulls haven't moved past the Round of 16 since posting a pair of shutout victories against Tottenham in 2019-20, when they ultimately lost to PSG in the semifinals.

Kickoff at Estadio Santiago Bernabeu is set for 3 p.m. ET. Los Blancos are -200 favorites (risk $200 to win $100) in the latest Real Madrid vs. RB Leipzig odds, while the Red Bulls are +450 underdogs. A 90-minute draw is priced at +360 and the over/under for total goals scored is 3.5. Before locking in any RB Leipzig vs. Real Madrid picks, you need to see what proven SportsLine soccer insider Jon "Buckets" Eimer has to say.

Eimer is a high-volume bettor who has vast knowledge of leagues and players across the globe. Since joining SportsLine, he has covered the English Premier League, Serie A, the FA Cup and much more. In 2023, he was red-hot, going 248-234-12 for a profit of $2,593 for $100 bettors. That included an 86-59-5 record in the Premier League for a $3,463 profit.

Now, Eimer has broken down Real Madrid vs. RB Leipzig from every angle and just revealed his picks and UEFA Champions League predictions. You can head to SportsLine now to see Eimer's picks. Here are the betting lines and trends for RB Leipzig vs. Real Madrid:

  • Real Madrid vs. RB Leipzig money line: Real Madrid -200, RB Leipzig +450, Draw +360
  • Real Madrid vs. RB Leipzig over/under: 3.5 goals
  • Real Madrid vs. RB Leipzig spread: Real Madrid -1.5 (+135)
  • RM: Los Blancos have won 19 of the 20 UCL ties in which they were victorious in the first leg
  • RBL: The Red Bulls are winless in their last six Champions League knockout matches
  • Real Madrid vs. RB Leipzig picks: See picks at SportsLine

Why you should back Real Madrid 

Los Blancos haven't lost since dropping a 4-2 decision against Atletico Madrid in the Copa del Rey on Jan. 18, posting six wins and three draws across all competitions. They have outscored their opponents 17-7 thus far in the Champions League, recording at least three goals in four of their seven matches. Jude Bellingham leads the club with four goals, while Brazilian winger Rodrygo and striker Joselu both have converted three times.

The 20-year-old Bellingham, who also is first in La Liga with 16 goals, scored in each of his first four UCL contests before notching an assist in Real Madrid's 3-2 triumph over Union Berlin in their group-stage finale. He did not play against RB Leipzig in the first leg due to an injury, but midfielder Brahim Diaz scored his second goal of the competition in the 48th minute to help give Los Blancos the victory. Brazilian winger Vinicius Junior also has converted twice in the Champions League and is second on Los Blancos in La Liga with nine goals. See which team to pick here.

Why you should back RB Leipzig

The Red Bulls are led offensively by Lois Openda, who also has scored four times in this competition. The 24-year-old Belgian striker, who is third in the German Bundesliga with 17 goals, netted three of his four goals in Leipzig's two group-stage losses to Manchester City. Openda, who recorded 21 goals for Lens of France's Ligue 1 last season, has converted in seven of his last 10 games across all competitions.

Benjamin Sesko and Xavi Simons both have scored twice for Leipzig in the Champions League. The 20-year-old Sesko has recorded seven goals in his first Bundesliga season with RB Leipzig after spending the previous three with RB Salzburg, with four coming over his last six league matches. Simons netted 19 goals for PSV Eindhoven of the Netherlands' Eredivisie in 2022-23 before joining Leipzig, for whom he has converted six times in 23 Bundesliga contests. See which team to pick here.

How to make Real Madrid vs. RB Leipzig picks

Eimer has broken down Wednesday's match from every possible angle and is leaning Over on the total. He also has locked in three confident best bets, including two that pay plus-money, and is offering a full breakdown of this Champions League match. He's sharing his Champions League picks and analysis only at SportsLine.

So who wins Real Madrid vs. RB Leipzig, and where does all the betting value lie? Visit SportsLine now to see which wagers in RB Leipzig vs. Real Madrid have all the value, all from the soccer expert who had a profit of almost $2,600 in 2023, and find out.