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The Cincinnati Bearcats look to avoid a three-game losing streak in the all-time series when they take on the Louisville Cardinals in the 2022 Fenway Bowl on Saturday. Cincinnati (9-3) owns a 30-22-1 record against Louisville (7-5) but lost the last two meetings -- both in overtime. The Bearcats have lost five of their last seven appearances to fall to 10-11 in bowl games, while the Cardinals are 11-12-1 after dropping three of their last four. These programs were linked by offseason news when former Louisville coach Scott Satterfield took the same position at Cincinnati. Both programs will have an interim coach for this one. 

Kickoff at Fenway Park in Boston is set for 11 a.m. ET. The Cardinals are 2-point favorites in the latest Louisville vs. Cincinnati odds from Caesars Sportsbook, while the over/under for total points scored is 38.5. Before locking in any Cincinnati vs. Louisville picks or Fenway Bowl 2022 predictions, be sure to check out what SportsLine's advanced computer model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisville vs. Cincinnati and just locked in its Fenway Bowl 2022 picks and predictions. You can head to SportsLine now to see the model's picks. Now, here are several college football odds and betting trends for Cincinnati vs. Louisville:

  • Louisville vs. Cincinnati spread: Cardinals -2
  • Louisville vs. Cincinnati over/under: 38.5 points
  • Louisville vs. Cincinnati money line: Cardinals -130, Bearcats +110
  • LOU: The Cardinals are 2-6 against the spread in their last eight neutral-site games
  • CIN: The Bearcats are 1-6-1 ATS in their last eight overall contests
  • Louisville vs. Cincinnati picks: See picks at SportsLine

Why Louisville can cover

The Cardinals' offense will be missing some key players as top receiver Tyler Hudson, quarterback Malik Cunningham and running back Tiyon Evans -- who are second and third, respectively, on the team in rushing -- have elected to skip the Fenway Bowl. Therefore, a lot will be riding on the shoulders of running back Jawhar Jordan, who leads Louisville with 700 yards on 133 carries. The redshirt sophomore has posted 100-yard performances in three of his last four outings and set a career high with 145 yards in the regular-season finale against Kentucky.

Big things will be expected from the defense, which is second in the nation with 43 sacks and third with 28 turnovers gained. Senior linebacker Yasir Abdullah was second in the ACC with eight sacks and seventh in the conference with 13 tackles for loss. The Cardinals are among the stingiest teams in the country when it comes to scoring as they rank 19th with an average of 20.2 points allowed. 

Why Cincinnati can cover

With Ben Bryant on the shelf with a foot injury, the Bearcats will have Evan Prater under center for the second consecutive game. The redshirt sophomore was more effective with his legs than his arm in a 27-24 loss to Tulane in the regular-season finale, rushing 18 times for 83 yards while completing only 10-of-26 pass attempts for 102 yards. When Prater does throw, he'll be looking to connect with junior wideout Tyler Scott, who has posted four 100-yard performances this year and leads the team with 899 receiving yards and nine touchdown catches.

Charles McClelland is Cincinnati's top rusher with 834 yards and seven TDs on 140 carries. Fellow senior Ryan Montgomery gives the team a second solid option as he has run for 270 yards and a career-high five scores on 63 attempts. Montgomery matched personal bests against Tulane with a team-leading 95 yards and two touchdowns as the Bearcats racked up a season-high 235 yards on the ground.

How to make Cincinnati vs. Louisville picks

SportsLine's model is leaning Over on the total, projecting 43 combined points. The model also says one side of the spread hits in almost 60% of simulations. You can only get the model's pick at SportsLine.

So who wins Louisville vs. Cincinnati? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.