Big Ten foes match up in college football Week 1 at Memorial Stadium when the Illinois Fighting Illini (1-0) hit the road to take on Indiana Hoosiers (0-0). This is the first contest between these two universities since 2017. The Hoosiers have won the last three games against the Fighting Illini. Meanwhile, Illinois kicked off the season in style. They defeated Wyoming 38-6 in a Week 0 battle last week.

Kickoff from the Memorial Stadium in Bloomington, Ind., is set for 8 p.m. ET. Caesars Sportsbook lists the Hoosiers as 1-point favorites in the latest Illinois vs. Indiana odds. The over/under for total points is set at 46.5. Before locking in any Indiana vs. Illinois picks or Week 1 college football predictions, you need to see what SportsLine's advanced computer model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Illinois vs. Indiana and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for Indiana vs. Illinois:

  • Illinois vs. Indiana spread: Hoosiers -1
  • Illinois vs. Indiana over/under: 46.5 points
  • Illinois vs. Indiana money line: Hoosiers -115, Fighting Illini -105
  • ILL: Fighting Illini is 4-0 ATS in their last four games overall
  • IU: Over is 4-1 in Hoosiers' last five games in September
  • Illinois vs. Indiana picks: See picks at SportsLine
Featured Game | Indiana Hoosiers vs. Illinois Fighting Illini

Why Illinois can cover

The Illinois aerial attack struggled during the 2021 season. The Illini were ranked last in the Big Ten in passing yards per game (156.2). Senior quarterback Tommy DeVito transferred in from Syracuse and is the man under center for the Fighting Illini. DeVito owns a strong arm with good field vision.

In the season-opening win over Wyoming, the New York native went 27 for 37 for 194 yards with two passing touchdowns. DeVito looks to build on that performance and move this offense successfully down the field. Sophomore receiver Pat Bryant led the team with 44 receiving yards on three grabs, including an 8-yard score. He's a deep threat with solid speed and sure hands. 

Why Indiana can cover

Indiana is looking to springboard their offensive attack. This unit had difficulties moving the ball consistently last season, ranking last in the conference in total yards (290) and 10th in passing yards per game (175.5). Newly-hired Walt Bell is now the offensive coordinator for the Hoosiers. They have a few transfer wideouts coming into town looking to make an impact. 

Senior receiver Emery Simmons is a smooth athlete hoping to seize a bigger role in this offense. Simmons owns a solid pair of hands and secured 30 catches for 516 yards and three touchdowns over three seasons at North Carolina. JUCO transfer Cam Camper flashed big-play ability during the 2021 campaign. He reeled in 28 passes for 505 yards and three scores at Trinity Valley. 

How to make Indiana vs. Illinois picks

SportsLine's model is leaning Under on the point total, projecting the teams to combine for 39 points. The model also says one side of the spread hits in well over 50% of simulations. You can only see the model's pick at SportsLine.

So who wins Illinois vs. Indiana? And which side of the spread hits in well over 50% of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.