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A non-conference matchup on Saturday night features the Stanford Cardinal (1-4) and the Notre Dame Fighting Irish (3-2) battling in prime time. Notre Dame is hoping to keep momentum on its side and secure a fourth straight win. Last week, the Fighting Irish upset then-16t ranked BYU 28-20. On the flip side, Stanford is on a four-game slide and is still looking for its first win against an FBS opponent this season. 

Kickoff from Notre Dame Stadium in South Bend, Ind., is set for 7:30 p.m. ET. The Fighting Irish are 16.5-point favorites in the latest Notre Dame vs. Stanford odds from Caesars Sportsbook. The over/under for total points is set at 54.5. Before finalizing any Stanford vs. Notre Dame picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Stanford vs. Notre Dame and just locked in its picks and CFB predictions. You can visit SportsLine now to see its picks. Here are the college football odds and betting lines for Notre Dame vs. Stanford:

  • Notre Dame vs. Stanford spread: Fighting Irish -16.5
  • Notre Dame vs. Stanford over/under: 54.5 points
  • Notre Dame vs. Stanford money line: Notre Dame -800, Stanford +550
  • STAN: Over is 4-0 last four Stanford games overall
  • ND: Fighting Irish are 4-0 ATS in their last four games in October
  • Notre Dame vs. Stanford: See picks at SportsLine

Why Notre Dame can cover

Sophomore running back Audric Estime is the leading tailback for the Fighting Irish. Estime is a bruising runner with the size (5-foot-11, 227 pounds) to run right through defenders. The New York native doesn't go down on the first hit, consistently piling up positive yards. Estime leads the team with 68 carries for 361 yards and four touchdowns.

Junior Chris Tyree is a change-of-pace back for Notre Dame. Tyree is a quicker and shifty runner for this offense. He can make defenders miss while being a weapon in the passing game. The Virginia native has 52 carries with 231 yards and 4.4 yards per carry. On Sept. 17 against California, Tyree logged 64 rushing yards and 44 receiving yards. 

Why Stanford can cover

Senior receiver Michael Wilson has been the lead man for the Cardinal passing attack. Wilson is able to box out defenders with his long arms and leaping ability. The California native is 6-foot-2 and has great hands. He's reeled in 17 catches for 352 yards and four touchdowns. On Sept. 24, he caught a season-best six receptions for 176 yards and two touchdowns.

Senior receiver Elijah Higgins is another big weapon on the outside (6-foot-3, 234 pounds). Higgins can line up in the slot or on the outside and win his matchup consistently. The Texas native is aggressive at the catch point. He has 19 catches for 215 yards and one score. In his last game, Higgins had four catches for 68 yards with 17 yards per reception. 

How to make Stanford vs. Notre Dame picks

SportsLine's model is leaning Over on the total, projecting the teams to combine for 60 points. The model also says one side of the spread hits in more than 60% of simulations. You can only get the pick at SportsLine.

So who wins Notre Dame vs. Stanford? And which side of the spread hits in more than 60% of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.