The 12th-ranked Notre Dame Fighting Irish have excelled in the Shamrock Series since its inception in 2009, winning all nine of the contests by an average of 22.8 points. However, they haven't played the annual off-campus regular-season home game since trouncing Syracuse 36-3 at Yankee Stadium in 2018. The series resumes Saturday as the Fighting Irish take on the No. 18 Wisconsin Badgers at Soldier Field in Chicago. Notre Dame also played a Shamrock Series game at the venue in 2012, when it rolled to a 41-3 victory over Miami (FL).

Kickoff is scheduled for noon ET. The Badgers are 6.5-point favorites in the latest Notre Dame vs. Wisconsin odds from Caesars Sportsbook, while the over-under for total points scored is 44. Before locking in any Wisconsin vs. Notre Dame picks, make sure you see the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Notre Dame vs. Wisconsin. You can visit SportsLine now to see the picks. Here are the college football odds and trends for Wisconsin vs. Notre Dame:

  • Wisconsin vs. Notre Dame spread: Badgers -6.5
  • Wisconsin vs. Notre Dame over-under: 44 points
  • Wisconsin vs. Notre Dame money line: Badgers -230, Fighting Irish +190
  • WIS: The Badgers are 6-1 against the spread in their last seven non-conference games
  • ND: The Fighting Irish are 1-4 ATS in their last five overall contests
Featured Game | Wisconsin Badgers vs. Notre Dame Fighting Irish

Why Wisconsin can cover

The Badgers are second in the nation in total defense and first against the run, so as a result, they also lead the country in possession time. Wisconsin, which has given up an average of 33 yards on the ground and 194.5 overall, has held on to the ball for 40 minutes, 57 seconds per contest. The Badgers have registered only four sacks thus far but are expected to get back junior linebacker Leo Chenal, who notched three in seven games last year but missed the first two contests in 2021 due to COVID-19.

After losing its season opener against Penn State, Wisconsin took out its frustration on Eastern Michigan, erupting for 518 total yards -- including 352 on the ground. Juniors Chez Mellusi (144) and Isaac Guerendo (92) accounted for the lion's share of the rushing yards, and each also ran for a touchdown. Freshmen Jalen Berger and Braelon Allen made their debuts and also scored while adding 62 and 30 yards, respectively.

Why Notre Dame can cover

The team has been a powerhouse since the beginning of the 2018 season, winning 36 of its 41 games -- including 35 regular-season victories. The Fighting Irish are 3-0 this season after posting a 27-13 triumph against Purdue last Saturday, a contest in which they received strong performances from a pair of defensive players. One was linebacker JD Bertrand, who matched his career high of 12 tackles to give him a double-digit total in three consecutive contests.

A sophomore, Bertrand ranks fifth in the nation with 35 tackles -- the most by a Notre Dame player over the first three games of a season since linebacker Courtney Watson registered 38 in 2001. Safety Kyle Hamilton also came up with a big effort against the Boilermakers, making 10 tackles and his third interception of the year. Notre Dame is tied for fifth in the nation with 13 sacks, its highest total to begin a season since it also had 13 in its first three contests in 1996.

How to make Wisconsin vs. Notre Dame picks

SportsLine's model is leaning under on the total, projecting 37 combined points. The model also says one side of the spread hits in well over 60 percent of simulations. You can only get the pick at SportsLine

So who wins Wisconsin vs. Notre Dame? And which side of the spread hits in well over 60 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.