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The No. 3 Ohio State Buckeyes and Indiana Hoosiers jump right into Big Ten play as they meet in Bloomington during the Week 1 college football schedule. Ohio State went 11-2 last season but left 2022 with a bitter taste after dropping the regular-season finale to rival Michigan and then falling to Georgia in the College Football Playoffs by just one point. Indiana, meanwhile, jumped out to a 3-0 start last season but then dropped eight of its last nine to finish 4-8, putting the pressure on head coach Tom Allen to turn it around quickly.

Kickoff is 3:30 p.m. ET on CBS and Paramount+. The latest Ohio State vs. Indiana odds from the SportsLine consensus list the Buckeyes as 29.5-point favorites in the latest Ohio State vs. Indiana odds while the over/under for total points scored is 59.5. Before locking in any Indiana vs. Ohio State picks, you need to see the college football predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed the model has seen huge returns.

Now the model has dialed in on Ohio State vs. Indiana and just revealed its coveted picks and predictions. You can head to SportsLine now to see the model's picks. Now, here are the college football odds and trends for Indiana vs. Ohio State:  

  • Ohio State vs. Indiana spread: Ohio State -30
  • Ohio State vs. Indiana over/under: 59 points 
  • Ohio State vs. Indiana money line: Ohio State -9643, Indiana +2067
  • OSU: 6-6-1 ATS last season 
  • IND: 4-8 ATS last season 
  • Ohio State vs. Indiana picks: See picks here
  • Ohio State vs. Indiana streaming: Paramount+

Why Ohio State can cover

Regardless of the quarterback situation, the Buckeyes have an embarrassment of riches at other skill positions. Receiver Marvin Harrison Jr. might be the nation's best and he'll likely be picked extremely early in the 2024 NFL Draft. He's joined by another 1,000-yard receiver from last year, Emeka Egbuka, giving the Buckeyes a 1-2 punch at receiver most teams could only dream of.

Ohio State's defense should be stout as the Buckeyes finished 13th in the national last year in total defense. Stopping big pass plays was a problem last year, but the Hoosiers might not have a competent enough of an aerial attack at this point to really hurt Ohio State in this area. See picks at SportsLine

Why Indiana can cover

An upset doesn't feel too feasible, but Indiana certainly has a great chance to keep this one with the massive spread. Indiana beat Illinois at home last season and then lost to its other Big Ten opponents at home by an average of 12.8 points. Ohio State, meanwhile, didn't beat any teams on the road by 30 or more last year, so this is a big number to cover.

Indiana hopes the talent level at quarterback is going up with Tayven Jackson, a former four-star recruit who began his career at Tennessee, potentially taking over. The Hoosiers also have four returning starters on the offensive line, some intriguing newcomers at running back via the transfer portal and a talented receiver in Cam Camper returning, giving this offense some paths to move the ball, even against a talented Ohio State unit. See picks at SportsLine

How to make Indiana vs. Ohio State picks

SportsLine's model is leaning Under on the point total, projecting the teams to combine for 58 points. It also says one side of the spread hits in more than 50% of simulations. You can see the model's pick at SportsLine

So who wins Ohio State vs. Indiana, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up almost $2,500 on top-rated spread picks since its inception, and find out, and don't forget to stream on Paramount+.