The seventh-ranked Kentucky Wildcats will meet the No. 14 Ole Miss Rebels in Oxford, Miss., for the first time since 2010 when they face off in an SEC crossover matchup on Saturday. The teams have played three times since, but all in Lexington, Ky. The Rebels (4-0) have won three of the last four meetings, with Kentucky last winning in Oxford in 1978. Ole Miss leads the all-time series 27-14-1. The Wildcats (4-0) defeated Northern Illinois 31-23 last week, while Ole Miss dumped Tulsa 35-27. Kentucky is set to have star running back Chris Rodriguez Jr. (suspension) in the lineup for the first time this season.

Kickoff from Vaught-Hemingway Stadium is set for noon ET. Kentucky averages 377.8 total yards per game in 2022, while Ole Miss averages 488. The Rebels are favored by 6.5 points in the latest Kentucky vs. Ole Miss odds from Caesars Sportsbook, while the over/under for total points scored is 55. Before making any Ole Miss vs. Kentucky picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ole Miss vs. Kentucky and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Kentucky vs. Ole Miss:

  • Kentucky vs. Ole Miss spread: Ole Miss -6.5
  • Kentucky vs. Ole Miss over-under: 55 points
  • Kentucky vs. Ole Miss money line: Kentucky +205, Ole Miss -250
  • UK: The Wildcats are 5-1-1 against the spread in their last seven games overall
  • MISS: The Rebels are 11-5-1 ATS vs. a team with a winning record
  • Kentucky vs. Ole Miss picks: See picks at SportsLine
Featured Game | Ole Miss Rebels vs. Kentucky Wildcats

Why Ole Miss can cover

The Rebels have a pair of explosive wide receivers in seniors Jonathan Mingo and Malik Heath. Mingo leads the team with 257 yards receiving on 12 receptions (21.4 average) and one touchdown. He has had three receptions in each game this season, including a 103-yard performance against Central Arkansas on Sept. 10. In four years at Ole Miss, Mingo has 73 receptions for 1,154 yards (15.8 average) and eight touchdowns.

Heath is tied for the team lead with 13 receptions for 220 yards (16.9 average) and three scores. Last week against Tulsa, Heath caught four passes for 75 yards (18.8 average) and one touchdown. He also had touchdown receptions in each of the first two games. For his career, he has 84 receptions for 969 yards (11.5 average) and 11 touchdowns.

Why Kentucky can cover 

The Wildcats have a stable of receivers who have lit up the opposition this season. Senior Tayvion Robinson leads the team with 20 receptions for 349 yards (17.5 average) and two touchdowns. Robinson was the difference in last week's win over Northern Illinois. He caught seven passes for 147 yards (21.0 average) and two touchdowns. It was his second 100-plus receiving game of the year. He caught six passes for 136 yards (22.7 average) in the season-opening win over Miami of Ohio.

Freshman Dane Key has made a big first impression for the Wildcats. He has 15 receptions, second-best on the team, for 241 yards (16.1 average) and three touchdowns. Key's best game was in a 31-0 Week 3 win over Youngstown State. In that game, he made six catches for 90 yards (15 average) and one touchdown. He also had receiving touchdowns against No. 12 Florida and Miami of Ohio.

How to make Kentucky vs. Ole Miss picks

SportsLine's model is leaning Under on the total, projecting 51 combined points. It has also generated an against the spread pick that cashes in well over 50% of simulations. You can only get the model's pick at SportsLine

So who wins Ole Miss vs. Kentucky? And which side of the spread cashes in well over 50% of simulations? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that finished the past six-plus years up more than $3,100 on its FBS college football picks, and find out.