| All Quarterbacks vs Bills | |||||||||||
| Passing | Rushing | ||||||||||
| Week | Team | 20+ | 40+ | CmpPct | YAtt | Lg | 2P | 20+ | Lg | 2P | FPTS |
| 1 | Ravens QB vs Bills [+] | 5 | 0 | 73.7 | 11.00 | 39 | 0 | 0 | 19 | 0 | 33 |
| 2 | Jets QB vs Bills [+] | 0 | 0 | 45.5 | 3.77 | 18 | 0 | 1 | 27 | 0 | 14 |
| 3 | Dolphins QB vs Bills [+] | 0 | 0 | 64.7 | 4.29 | 19 | 0 | 0 | 8 | 0 | 16 |
| 4 | Saints QB vs Bills [+] | 0 | 0 | 66.7 | 4.67 | 17 | 0 | 0 | 15 | 0 | 15 |
| 5 | Patriots QB vs Bills [+] | 4 | 0 | 73.3 | 9.10 | 32 | 0 | 0 | 9 | 0 | 11 |
| 6 | Falcons QB vs Bills [+] | 6 | 0 | 62.5 | 7.81 | 39 | 0 | 0 | 7 | 0 | 16 |
| 8 | Panthers QB vs Bills [+] | 1 | 0 | 66.7 | 7.29 | 22 | 0 | 0 | 1 | 0 | 1 |
| 9 | Chiefs QB vs Bills [+] | 7 | 1 | 44.1 | 7.35 | 40 | 1 | 0 | 5 | 0 | 10 |
| 10 | Dolphins QB vs Bills [+] | 3 | 0 | 71.4 | 8.24 | 38 | 0 | 0 | 0 | 0 | 14 |
| 11 | Buccaneers QB vs Bills [+] | 2 | 0 | 57.1 | 6.18 | 28 | 0 | 0 | 13 | 0 | 17 |
| 12 | Texans QB vs Bills [+] | 2 | 0 | 53.3 | 5.10 | 33 | 0 | 0 | 5 | 0 | 18 |
| 13 | Steelers QB vs Bills [+] | 1 | 0 | 41.7 | 4.88 | 26 | 0 | 0 | 0 | 0 | 0 |
| 14 | Bengals QB vs Bills [+] | 3 | 0 | 69.4 | 7.89 | 37 | 0 | 0 | 0 | 0 | 31 |
| 15 | Patriots QB vs Bills [+] | 1 | 0 | 60.9 | 6.74 | 30 | 0 | 0 | 17 | 0 | 20 |
| 16 | Browns QB vs Bills [+] | 2 | 0 | 69.0 | 5.41 | 26 | 0 | 0 | 16 | 0 | 12 |
| 17 | Eagles QB vs Bills [+] | 1 | 0 | 48.1 | 4.07 | 27 | 0 | 0 | 4 | 0 | 10 |
| 18 | Jets QB vs Bills [+] | 0 | 0 | 50.0 | 2.73 | 13 | 1 | 0 | 5 | 0 | 10 |
| 19 | Jaguars QB vs Bills [+] | 2 | 0 | 60.0 | 6.90 | 34 | 0 | 0 | 18 | 0 | 25 |
| 20 | Broncos QB vs Bills [+] | 5 | 0 | 56.5 | 6.07 | 29 | 0 | 0 | 11 | 0 | 29 |
| Average | 2.37 | 0.05 | 59.70 | 6.28 | 0.00 | 0.11 | 0.10 | 0.00 | 0.00 | 16.26 | |
| Season | All Quarterbacks vs Bills | 45 | 1 | 59.7 | 6.28 | 40 | 2 | 1 | 27 | 0 | 302 |